Clinical trials: Metabolic Regulation
Obesity, Prediabetes
ADRB3 Signaling Pathway in Human Adipose Tissue
This study will examine the gene expression of the adrenergic Beta-3 receptor (ADRB3) regulation in human subcutaneous adipose tissue before and after treatment with mirabegron, an ADRB3 agonist.
- Trial name
- NCT05634174
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hyperlipidemia
Regulation of Intestinal and Hepatic Lipoprotein Production by Glucose and Fructose
Increased postprandial plasma triglycerides are associated with increased cardiovascular risk. Chronic consumption of carbohydrates is associated with increased levels of triglycerides.
- Trial name
- glucose (NCT01694446)
- Testing
- Intraduodenal glucose or fructose
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes Mellitus
Incretin Therapy and Exercise in Type 2 Diabetes
This study will examine changes in brain and physical health in adults with type 2 diabetes who are initiating incretin-mimetic therapy (e.g., Ozempic, Mounjaro), and determine whether adding structured exercise provides…
- Trial name
- BIOM (NCT07833813)
- Testing
- Structured Exercise Program
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- University of Regina
Coronary Artery Disease, Type 2 Diabetes Mellitus (T2DM)
Effects of Fecal Microbiota Transplantation in Patients With Type 2 Diabetes and Coronary Artery Disease (CAD-Microbiome) - A Pilot Study
This pilot study investigates whether fecal microbiota transplantation (FMT) can modify the gut microbiome in patients with type 2 diabetes mellitus and stable coronary artery disease (CAD).
- Trial name
- CAD-Microbiome (NCT07421947)
- Testing
- Fecal Microbiota Transplantation
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Hypoglycemia Unawareness, Diabetes Mellitus, Type 1
Glucagon Infusion in T1D Patients With Recurrent Severe Hypoglycemia: Effects on Counter-Regulatory Responses
This is a prospective, randomized, controlled, double-blind, parallel 4-group trial with the primary analysis after 4 weeks of treatment with continuous subcutaneous glucagon infusion (CSGI) or placebo.
- Trial name
- NCT03490942
- Testing
- Glucagon
- Where
- 5 sites in United States
- Volunteers
- 49 people
- Sponsor
- Xeris Pharmaceuticals
Insulin Resistance
Regulation of Endogenous Glucose Production by Brain Insulin Action in Insulin Resistance
It is well known that the hormone insulin lowers blood glucose in part by acting directly on the liver and reducing hepatic glucose production.
- Trial name
- NI EGP highBMI (NCT03383822)
- Testing
- Intranasal insulin
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Polycystic Ovarian Syndrome, Obesity, Abdominal
Acupuncture in the Regulation of Dai Meridian for Polycystic Ovarian Syndrome Patients With Abdominal Obesity
The purpose of this study is to determine whether the use of electroacupuncture to dredge and regulate Dai Meridian combined with lifestyle modification are more effective than lifestyle modification only in the treatment of…
- Trial name
- NCT02785965
- Testing
- electroacupuncture, lifestyle modification
- Where
- 2 sites in China
- Volunteers
- 84 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Obesity, Weight Loss
Hormonal Regulation of Body Weight Maintenance
The investigators here propose to perform a collaborative clinical research effort including a randomized controlled trial investigating the mechanisms of weight maintenance and their relation to a lifestyle intervention in…
- Conditions
- Obesity, Weight Loss, Weight Gain, Hormone Disturbance
- Trial name
- NCT00850629
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Obesity, Aging
Appetite Regulation in Older-Aged Obese Individuals
This study plans to learn more about how age and weight impact appetite and food intake. Specifically, this study is being done to see whether age and obesity impact appetite and the brain's response to food.
- Trial name
- NCT02721303
- Testing
- 3-day diet Run-in, fMRI, Intravenous catheter placed for blood draws
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
PreDiabetes, Impaired Glucose Tolerance
Almonds and Health Effects on Metabolism, Vascular Function and Cognition
The primary objective of the proposed study is to examine and understand the impact of long-term almond consumption on chronic glucose metabolism in subjects with impaired glucose tolerance and/or impaired fasting glucose.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Impaired Fasting Glucose, Overweight and Obesity
- Trial name
- NCT03419702
- Testing
- Almonds
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Maastricht University Medical Center
Hypertension, Metabolic Syndrome
Regulation of Inflammatory Parameters by Telmisartan in Hypertensive Patients
A number of studies have shown that certain blood-pressure medications such as ACE-inhibitors and angiotensin-II-receptor blockers (ARB) can reduce the incidence of diabetes mellitus type 2.
- Conditions
- Hypertension, Metabolic Syndrome, Hypertriglyceridemia
- Trial name
- METATEL (NCT00560430)
- Testing
- telmisartan
- Where
- 2 sites in Germany
- Volunteers
- 56 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Healthy Subjects
Effect of Oat Compounds on Postprandial Glucose Response
In this project we will investigate synergistic effects of oat polar lipids and beta glucans on postprandial glucose tolerance
- Trial name
- NCT05177172
- Testing
- High beta glucans, Low beta glucans, Low beta glucans + low polar lipids
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Type 1 Diabetes
FAMS-T1D Self-Regulation and Social Support for T1D
The goal of this clinical trial is to evaluate how effective the FAMS-T1D intervention is for improving self-regulation (e.g., setting and meeting goals for type 1 diabetes) and social support for meeting those goals for young…
- Trial name
- FAMS-T1D (NCT05820477)
- Testing
- FAMS-T1D, Digital resources for diabetes
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- University of Utah
Overweight and Obesity
Improving Emotion Regulation Skills Among Adolescents Attempting to Lose Weight
While the prevalence of overweight and obesity among children and adolescents has plateaued, national data indicate that approximately 35% of children and adolescents continue to struggle with overweight/obesity.
- Trial name
- NCT03393221
- Testing
- ER, SBWC
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Overweight, Obesity
A Study of the Effects of Intake of Two Cod Residual Meals on Glucose Regulation in Overweight and Obese Adults
The investigators have previously shown the intact protein from cod filet improves glucose regulation and serum lipid profile in overweight adults.
- Trial name
- FISK4 (NCT01894542)
- Testing
- Cod protein from presscake, Cod protein from presscake + stickwater, Control
- Where
- Norway
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Cryotherapy, Training
Short to Long Effects of Whole Body Cryostimulation on Insulin Sensitivity Among Overweight
Therapeutic effectiveness of coldness in relieving pain and reducing inflammation has been known for many years now. Over that time, various coldness therapies have gained in popularity, including winter swimming, snow baths or…
- Conditions
- Cryotherapy, Training, Overweight, Insulin
- Trial name
- NCT04375969
- Testing
- whole body cryostimulation treatment, Connection WBC treatment and HIIT training, Control Group
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Metabolic Disturbance
Isothiocyanates and Metabolic Health
Many sprouts, for example broccoli sprouts, contain substances that have shown to have protective effects, both against oxidative stress and against carcinogenic substances.
- Trial name
- IMH (NCT05070585)
- Testing
- Isothiocyanate rich sprouts
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Health, Appetite Regulation
Sodium Alginate in Chocolate Milk, Satiety and Glycemic Control
This study compares the effects of isovolumetric (325 ml) preloads of chocolate milk supplemented with sodium alginates at incremental doses on inter-meal glucose levels, appetite scores and food intake in healthy adult men.
- Conditions
- Health, Appetite Regulation, Glucose Metabolism
- Trial name
- NCT01877460
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hyperglycemia, Obesity Prevention
The Impact of Low Glycemic Index Nutritional Shake on Glucose Regulation in Overweight and Obese Adults
Low glycemic index nutritional shakes have clinically shown to improve post-prandial glycemic responses in acute laboratory control studies.
- Trial name
- SHAKE (NCT06856460)
- Testing
- powder shake with very low glycemic index, Ceral Breakfast
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Metabolic Diseases, Immune System Disorder
Study on the Effects of Wheat and Corn Germ Blend Oil on Antioxidation and Immune Regulation of Dyslipidemia Population
The goal of this clinical trial is to explore the role of wheat and corn germ blended oils in regulating oxidative stress and immunomodulation in dyslipidaemic populations, to explore their effects on intestinal flora…
- Conditions
- Metabolic Diseases, Immune System Disorder, Dyslipidemias, Fatty Acid Metabolism Disorder
- Trial name
- NCT06060509
- Testing
- Phytosterol-rich Wheat and Corn Germ Blended Oil, Peanut oil
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Southeast University, China