Clinical trials: Metabolic Regulation, open to volunteers
Type 2 Diabetes, Appetite Regulation
GLycaemic Outcomes With Whey Protein in ageING
The goal of this placebo-controlled, partial crossover design study is to identify the impact of consuming whey protein before meals on free-living glucose control in older adults living with type 2 diabetes.
- Conditions
- Type 2 Diabetes, Appetite Regulation, Whey Protein, Ageing and Geriatric Health
- Trial name
- GLOWING (NCT07285811)
- Testing
- Glycaemic control with whey protein, Glycaemic control with different doses of whey protein
- Where
- 2 sites in United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Hypoparathyroidism
Hypoparathyroidism Natural History Study
This is a prospective three-year natural history study of adults with hypoparathyroidism. The goal is to monitor patients with hypoparathyroidism to define end-organ damage in the context of the disease.
- Trial name
- SHINE (NCT05793853)
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Columbia University
Non-alcoholic Fatty Liver, Atherogenic Dyslipidemia
Genetic Pathways Leading to Fatty Liver and Atherogenic Dyslipidemia
The aims of the study are: 1. To investigate if carriers of apolipoprotein (apo) CIII loss-of-function (LOF) mutations produce less apo-CIII that results in reduction of large very low-density lipoprotein (VLDL) particle…
- Conditions
- Non-alcoholic Fatty Liver, Atherogenic Dyslipidemia, Insulin Resistance
- Trial name
- VARKIN (NCT04209816)
- Testing
- Lipoprotein kinetics
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 100 people
- Sponsor
- Marja-Riitta Taskinen
Overweight and Obese Adults, High Intensity Interval Exercise (HIIE)
Acute Effects of Isoenergetic HIIE vs. MICE on Key Parameters of Fat Mass Loss in Young Females With Overweight or Obesity
Overweight and obesity, particularly increased total and/or abdominal fat mass (FM), are strongly linked to the development of cardiovascular diseases.
- Trial name
- COMEFIT (NCT06868862)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Obesity, Childhood
Development of an Eating Behavior Risk Score
This study will explore how children's eating behaviors are connected to brain activity and body fat levels. Researchers are especially interested in a behavior pattern called the PACE phenotype, which includes how much children…
- Trial name
- PACE (NCT07266506)
- Testing
- Assessment of PACE Eating Phenotype and Related Behavioral and Neurobiological Measures
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Penn State University
Polycystic Ovarian Syndrome (PCOS)
Time Restricted Feeding Model in Women With Polycystic Ovary Syndrome
This study aims to evaluate the effects of a 16:8 time-restricted feeding (TRF) model on anthropometric, metabolic, and hormonal parameters in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT06807775
- Testing
- Dietary Intervention (time-restricted feeding model (16:8)), Dietary Intervention (energy restricted dietary intervention)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Kidney Disease Mineral and Bone Disorder
The Effect of REgulation of PArathyroId hoRmone in Patients With Chronic Kidney Disease to Investigate the Change in Bone Mineral Density
The prevalence of chronic kidney disease (CKD) in the adult population is estimated to 10%. CKD increases risk of bone fractures, cardiovascular disease and death.
- Trial name
- REPAIR-CKD (NCT07171216)
- Testing
- Treat to target
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Herlev Hospital
Metabolic Regulation, Energy Expenditure
Effects of Intermittent Running on Metabolic Health
The purpose of this study is to investigate the suitability of intermittent exercise of long and short intervals at lower intensities than HIIE on energy expenditure during and post-exercise compared to MICE, as well as determine…
- Trial name
- NCT06962605
- Testing
- Moderate-intensity continuous running (MICE: 60% V̇O2max), 5-minute interval running (5MIN), 2-minute interval running (2MIN)
- Where
- Taiwan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Intestinal Failure
Spectral Lighting and Metabolism
The goal of this exploratory n-of-1-study is to compare markers of metabolism in infants in a Level IV Neonatal Intensive Care Unit (NICU) between two lighting environments.
- Trial name
- NCT06094504
- Testing
- Spectral Lighting
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Prediabetes, Impaired Fasting Glucose
Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)
Prediabetes affects millions of adults worldwide and carries a high risk of progression to type 2 diabetes. Mazdutide is a once-weekly injectable drug that activates both GLP-1 and glucagon receptors, lowering blood sugar and…
- Conditions
- Prediabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance (Prediabetes)
- Trial name
- DREAM-PRE (NCT07654062)
- Testing
- Mazdutide, Standardized Lifestyle Intervention
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shandong Provincial Hospital
Diabetes Mellitus, Diabetic Retinopathy
Sleep, Diabetic Retinopathy and Melatonin
This study explores the use of melatonin in patients with diabetic retinopathy
- Trial name
- NCT04547439
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Illinois Chicago
Obesity & Overweight, Metabolic Disorders
Diet and WB-EMS Effects in Obesity
Obesity is a major global health problem associated with metabolic dysfunction, altered adipokine signaling, and impaired appetite regulation.
- Conditions
- Obesity & Overweight, Metabolic Disorders, Electrotherapy
- Trial name
- DEMO-OB (NCT07562724)
- Testing
- Energy-Restricted Diet, Whole-Body Electromyostimulation (WB-EMS)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Firat University
Obesity; Impaired Glucose Regulation; Prediabetes; Type 2 Diabetes Mellitus
Time-Restricted Eating and Staple Food Reduction Combined With App-Supported Exercise for Weight and Glycemic Control
This multicenter, three-arm randomized controlled trial will evaluate the effects of early time-restricted eating and staple food reduction, each combined with an app-supported exercise intervention, on body weight and glycemic…
- Trial name
- TRE-SFR-EX (NCT07726615)
- Testing
- App-Supported Exercise Intervention, Staple Food Reduction, Early Time-Restricted Eating
- Volunteers
- 300 people
- Sponsor
- Peking University
Body Awareness, Obesity
Group Skills Training for Body Awareness and Managing Emotions
The goal of this study is to evaluate the effectiveness of a skills training group informed by polyvagal theory, when delivered in an NHS setting, for those living with obesity.
- Conditions
- Body Awareness, Obesity, Emotional Regulation
- Trial name
- NCT07315763
- Testing
- Polyvagal informed skills training group
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Holloway University
Obesity (Disorder), Overweight , Obesity
I-OPERA: A European Study Testing a New Way to Do Health Research.
The goal of this observational pilot study is to evaluate whether a participant-mediated, direct-to-participant research approach is a feasible and effective way to collect health data from adults living with obesity in England…
- Trial name
- I-OPERA (NCT07759544)
- Volunteers
- 105 people
- Sponsor
- IQVIA RDS Spain, SL
Healthy, Diabetes Mellitus Type 1
The Effect of Light Therapy on Cellular Energy and Oxidative Stress in Healthy Adults and Type 1 Diabetic Patients
The goal of this clinical trial is to evaluate the effects of low-level light therapy on cellular energy and oxidative stress in healthy adults and patients with Type 1 diabetes.
- Trial name
- PBM-T1D (NCT07833865)
- Testing
- Red and Near-Infrared Light Therapy Pad
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Thi-Qar
Type 2 Diabetes Mellitus
Incretin Therapy and Exercise in Type 2 Diabetes
This study will examine changes in brain and physical health in adults with type 2 diabetes who are initiating incretin-mimetic therapy (e.g., Ozempic, Mounjaro), and determine whether adding structured exercise provides…
- Trial name
- BIOM (NCT07833813)
- Testing
- Structured Exercise Program
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- University of Regina
Coronary Artery Disease, Type 2 Diabetes Mellitus (T2DM)
Effects of Fecal Microbiota Transplantation in Patients With Type 2 Diabetes and Coronary Artery Disease (CAD-Microbiome) - A Pilot Study
This pilot study investigates whether fecal microbiota transplantation (FMT) can modify the gut microbiome in patients with type 2 diabetes mellitus and stable coronary artery disease (CAD).
- Trial name
- CAD-Microbiome (NCT07421947)
- Testing
- Fecal Microbiota Transplantation
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Obesity, Weight Gain
Exercise, Brain Activity, and Weight Maintenance
This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.
- Conditions
- Obesity, Weight Gain, Bariatric Surgery Candidate, Appetitive Behavior
- Trial name
- NCT06511310
- Testing
- Exercise
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Obesity
Metacognitive Beliefs in Obese Patients
The study aims to investigate the presence of metacognitive beliefs, emotional regulation, and emotional eating in obese patients and their possible relationships.
- Trial name
- METAOBES (NCT06800911)
- Testing
- Questionnaires
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Istituto Auxologico Italiano