Clinical trials: Metabolic Response to Dietary Modification
Vitamin D Deficiency
Nutritional Requirements for Vitamin D in Pregnant Women
Randomised, placebo-controlled dose-response intervention study with vitamin D3 in pregnant women.
- Trial name
- DMAT (NCT02506439)
- Testing
- 10 mcg Vitamin D3, 20 mcg Vitamin D3
- Where
- 2 sites in Ireland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University College Cork
Overweight and Obesity, Diabetes Mellitus, Type 2
Looking for Personalized Nutrition for Obesity/Type 2 Diabetes Mellitus Prevention
The objectives of this trial are to assess the effects of interactions between genetic factors and diet with various macronutrient intake on the metabolic disorders, obesity and type 2 diabetes risk, prevention, development and…
- Conditions
- Overweight and Obesity, Diabetes Mellitus, Type 2, Metabolic Syndrome, Genetic Predisposition
- Trial name
- NCT03792685
- Testing
- Normo-carbohydrate meal intake, High-carbohydrate meal intake, High-fat meal intake
- Where
- Poland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Weight Loss, Muscle Loss
Effects of Dietary Protein on Musculoskeletal Health During Calorie Deficiency
Military personnel face many physiological challenges, including sustained physical activity and prolonged periods of negative energy balance.
- Conditions
- Weight Loss, Muscle Loss, Bone Loss
- Trial name
- NCT01292395
- Testing
- Dietary Protein Intake
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Obesity, Childhood
Nutrition Intervention to Measure Metabolic Response in Children
The long-term objective of this study is to determine if habitual consumption of high-quality protein at breakfast will lead to improved energy metabolism and decreased daily energy intake in normal weight and overweight…
- Trial name
- NCT03139773
- Testing
- Control Breakfast Beverage, Omega-3 Breakfast Beverage
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Cardiovascular Diseases
Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance
This study is being conducted to learn more about the role of diet and exercise in regulating plasma triglyceride (fat) metabolism.
- Trial name
- DEV (NCT00830999)
- Testing
- Positive energy balance, Energy balance with exercise, Negative energy balance
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetes, Heart Diseases
Personalized Responses to Dietary Composition Trial 3
The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- NCT04735835
- Testing
- Dietary Intervention
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- Zoe Global Limited
Metabolic Response to Dietary Modification
NUtriGenomic Analysis in Twins
This is an intervention study in healthy adult twins with the aim to investigate the genetic determination of metabolic responses towards an isocaloric high carbohydrate, low fat diet versus an isocaloric low carbohydrate, high…
- Trial name
- NUGAT (NCT01631123)
- Testing
- Isocaloric high carbohydrate diet intervention, Isocaloric high fat diet intervention
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Diet Modification, Insulin Resistance
Saliva Insulin Responses to a Standardized Meal Tolerance Test in Humans
Recent evidence suggests that hyperinsulinemia (i.e., elevated insulin levels) is the primary causative factor in obesity. Insulin promotes fat storage and prevents fat breakdown, suggesting that weight loss would be optimized if…
- Conditions
- Diet Modification, Insulin Resistance, Hyperinsulinemia
- Trial name
- NCT04309071
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetes, Heart Diseases
Personalised Responses to Dietary Composition Trial
The foods we eat - our diet - can affect whether we develop diseases during our lives, such as diabetes or heart disease. This is because the amount and types of foods we eat can affect our weight, and because different foods are…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- PREDICT (NCT03479866)
- Testing
- Dietary intervention
- Where
- United Kingdom
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Metabolic Response to Dietary Modification
The CLOCK Study - A Human Dietary Intervention Study on Peripheral Circadian Clocks and Energy Metabolism
This human dietary intervention study with a cross-over design aims to investigate the effect of two different diurnal patterns of meal composition on peripheral circadian clocks and energy metabolism in healthy men.
- Trial name
- CLOCK (NCT02487576)
- Testing
- Carbohydrate-rich (HC), Fat-rich (HF)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
NAFLD (Nonalcoholic Fatty Liver Disease)
Integrating Metabolic and Vascular Sensors to Monitor Cardiometabolic Disorders After Nutrition Interventions
It is a 12-week study. The participants will follow three different diets, and during each diet period, and the participants will wear our device, and blood samples will be collected.
- Trial name
- NCT06932289
- Testing
- Mediterranean diet (MED), high-fat/low carb diet (HF/LC), and low-fat diet (LF), The integrated sweat sensor and vascular sensor (wearable), continuous glucose monitor (CGM)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- VA Greater Los Angeles Healthcare System
Healthy, Weight Loss
Adaptations of Exercise Energy Metabolism in Response to Weight Loss in Healthy Normal Weight People
More and more normal weight people are dieting in the general population. The NUTRILEX study aims to better understand the physiological adaptations in response to weight loss in healthy normal weight individuals.
- Conditions
- Healthy, Weight Loss, Body Weight, Diet Habit
- Trial name
- NUTRILEX (NCT05370222)
- Testing
- Dietary weight loss intervention
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Metabolic Flexibility
Metflex: The Effectiveness of a Dietary Intervention
This study is testing the effectiveness of a dietary intervention by means of measuring the change in RQ upon a hyperinsulinemic euglycemic clamp challenge and by means of measuring the kinetic responses of multiple PF markers…
- Trial name
- NCT02519127
- Testing
- Low glycaemic load diet, Western diet
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Pre Diabetes, Vascular Stiffness
Dietary Exchanges With Avocado and Mango in Pre-diabetes
The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals…
- Conditions
- Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change
- Trial name
- AVMa (NCT05353790)
- Testing
- Meals + snacks: control, Meals + snacks: Avocado mango
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Vegan Diet, Body Composition
Acute Metabolic Response Versus Long-term Adaptation to a Vegan Diet
At baseline, venous blood samples were collected from all eligible participants. The following biochemical parameters were analysed: serum electrolytes (mineral profile), fasting glucose, creatinine, urea nitrogen, total…
- Conditions
- Vegan Diet, Body Composition, Quality of Life (QOL), Cardiometabolic Health
- Trial name
- VITAL (NCT07731633)
- Testing
- vegan diet
- Where
- Slovakia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Martin
Low Protein Dietary Intake, High Protein Dietary Intake
The Body's Response to Changes in Dietary Protein and Meal-Frequency In Men
the purpose of this study is to identify how the body responds to increased dietary protein (that includes pork and eggs) and meal-frequency in adult men.
- Trial name
- NCT01171716
- Testing
- Meal Patterning
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Purdue University
Endotoxemia, Intestinal Microbiota
Dietary Intervention to Reduce Metabolic Endotoxemia
The goal of this randomized clinical trial is to compare an antiinflammatory and environmentally friendly dietary strategy (AIA-D) designed based on the planetary health diet recommendations translated to the regional context and…
- Conditions
- Endotoxemia, Intestinal Microbiota, Dietary Habits, Clinical Trial
- Trial name
- NCT05776329
- Testing
- AIA-D, CONV-D
- Where
- 2 sites in Mexico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Shift Work
Measuring the Cardio-metabolic Response to Diet Quality Modification During Night Work.
The aim of this pilot study is to investigate the acute impact of diet quality modification during night work on 24-hr glucose variability (GV) and heart rate variability (HRV) in healthy free-living employees.
- Trial name
- NCT04182867
- Testing
- Dietary intervention
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- King's College London
Diabetes, Heart Diseases
PREDICT 2: Personalized Responses to Dietary Composition Trial 2
Foods in the human diet can affect the development of diseases over time, such as diabetes or heart disease. This is because the amount and types of foods in the diet eat can affect a person's weight, and because different foods…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- NCT03983733
- Testing
- Dietary Intervention
- Where
- United States
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- Zoe Global Limited
Dietary Modification, Healthy
Acute Glycemic and Insulinemic Response of FOSSENCE™
Short chain fructooligosaccharide (FOS) is known as a prebiotic fiber/nutrient and has been documented to demonstrate different health benefits including glucose control, gut health, mineral absorption, weight and immunity.
- Trial name
- NCT03755232
- Testing
- scFOS, Control
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TATA CHEMICALS LTD