Clinical trials: Metabolic Risk Factors
Type II Diabetes Mellitus
Rosiglitazone and Exercise in Patients With Type 2 Diabetes Mellitus
The aim of the present study is to investigate the influence of systemic exercise, rosiglitazone administration and combined pharmaceutical and lifestyle intervention on cardiovascular risk factors
- Trial name
- NCT00306176
- Testing
- Rosiglitazone
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Endometrial Cancer, Genetic Predisposition
Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle Factors
Endometrial cancer (EC) is one of the most prevalent cancers in women worldwide with a significantly increasing incidence, especially in developed countries.
- Conditions
- Endometrial Cancer, Genetic Predisposition, Risk Behavior
- Trial name
- MPEC (NCT06680791)
- Where
- Czechia
- Volunteers
- 280 people
- Sponsor
- Lukas Vanek
Lactose Malabsorption, Cardiovascular Disease
Whole Milk Intake and Cardio-metabolic Risk Factors
Milk is the source of high-quality protein, calcium, and other vitamins and minerals. Epidemiologic studies have linked high consumption of milk with risk of metabolic syndrome, T2DM, hypertension and obesity, which are…
- Trial name
- NCT02798718
- Testing
- full-fat milk
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Physical Activity, Overweight
Intervention Centered on Adolescents' Physical Activity and Sedentary Behavior (ICAPS)
Physical activity is thought to be a key element in preventing the obesity epidemic and the associated cardiovascular and metabolic diseases.
- Conditions
- Physical Activity, Overweight, Cardiovascular Disease
- Trial name
- ICAPS (NCT00498459)
- Testing
- Physical activity
- Where
- France
- Volunteers
- 954 people, healthy volunteers welcome
- Sponsor
- Louis Pasteur University, Strasbourg
Nutritional Status
Impaired Preoperative Nutritional Status as a Risk Factor for Postoperative Clinical Outcome
The aim of this retrospective observational study is to determine the impact of preoperative nutritional status on postoperative outcome.
- Trial name
- PreopBIA (NCT01492946)
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Charite University, Berlin, Germany
Diabetes Mellitus, Type 2, Hypertension
Olive Leaf Extracts in the Control of Cardiovascular Risk
This study will be carried out in 2 emergency departments (at the exit of the emergency room) and 2 external consultations (endocrinology of the CHU FB Monastir and diabetology consultation, Jemmal hospital).
- Trial name
- Atherolive (NCT05297110)
- Testing
- atherolive
- Where
- Tunisia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Obesity, Overweight
Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese Subjects
The purpose of this Phase 3b study is to assess the effects of combination therapy with naltrexone SR/bupropion SR (NB) used in conjunction with a comprehensive lifestyle intervention (CLI) and in a manner consistent with its…
- Trial name
- NCT01764386
- Testing
- NB, CLI, Usual Care
- Where
- 15 sites in United States
- Volunteers
- 242 people
- Sponsor
- Orexigen Therapeutics, Inc
Cardiovascular Disease Prevention, Cardiometabolic Diseases
Preventative Screening and Health Coaching in a Food Insecure Population
The goal of this longitudinal study is to investigate the role of virtual health coaching on mitigation of cardiometabolic disease risk in an underserved, food insecure population.
- Conditions
- Cardiovascular Disease Prevention, Cardiometabolic Diseases, Cardiovascular Risk Factor, Cardiovascular Risk Score
- Trial name
- HEALTHCOACH (NCT06907524)
- Testing
- Longitudinal, Individualized Health Coaching
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
Type 2 Diabetes
Vitamin D Supplementation on Cardiovascular Risk Factors
The purpose of the present pilot study is to determine the effect of vitamin D supplementation (4000 IU or 6000 IU once daily for 6 months) on reducing heart disease risk and in improving blood glucose control in type 2 Diabetes…
- Trial name
- NCT01412710
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Florida International University
Systemic Hypertension, Obesity
GAstric Bypass to Treat obEse Patients With steAdy hYpertension
Phase 3, unicentric, randomized clinical trial, with allocation concealment and intention-to-treat analysis to evaluate the efficacy of videolaparoscopic Roux-en-Y Gastroplasty to decrease the prescription of antihypertensive…
- Trial name
- GATEWAY (NCT01784848)
- Testing
- Laparoscopic Roux-en-Y gastric bypass (LRYGB), Clinical treatment
- Where
- 3 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital do Coracao
Cardiovascular Diseases, Heart Diseases
Genetics of CVD Risk Factors in Samoans
To evaluate the role of known genes involved in lipid metabolism on serum lipid and apolipoprotein levels in Samoans residing in American and Western Samoa, who were exposed to the biobehavioral changes of modernization.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Atherosclerosis
- Trial name
- NCT00005528
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Participants With/Without Risk Factors for Metabolic Diseases
Nutrient And Non-Nutrient Intake, Relative Biomarkers and Their Health Effects In Apparently Healthy Participants
This observational study aims to provide a comprehensive evaluation of dietary habits, physical activity, biomarkers involved in nutrition, metabolic and inflammatory status as well as intestinal permeability in apparently…
- Trial name
- NUTRI-BRIDGE (NCT07110805)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Milan
Childhood Obesity, Adiposity
Lifestyle in Pregnancy and Offspring
Children born to obese women are at risk of increased adiposity and later adverse metabolic outcomes. We have conducted a follow-up study on an existing clinical trial, called the LiP study (Lifestyle in Pregnancy), registration…
- Conditions
- Childhood Obesity, Adiposity, Body Composition, Metabolic Risk Factors
- Trial name
- LiPO (NCT01918319)
- Testing
- Lifestyle intervention
- Where
- Denmark
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
HIV Infections
Long-Term Data Collection From Participants in Adult AIDS Clinical Trials
The purpose of this study is to determine what combinations of anti-HIV drugs work best in patients treated over several years. The study will also assess the occurrence of side effects and opportunistic infections in patients…
- Trial name
- NCT00001137
- Where
- 77 sites in United States, Puerto Rico
- Volunteers
- 5,982 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Childhood Obesity, Dyslipidemia
Nutritional Treatment of Overweight Adolescents With Cardiovascular Risk Factors (PowerUp)
This study is designed to evaluate the efficacy of two diets, a low glycemic load diet and a low saturated fat diet, in the treatment of adolescents with some heart disease risk factors associated with being overweight, such as…
- Conditions
- Childhood Obesity, Dyslipidemia, Insulin Resistance, Hypertension
- Trial name
- NCT00477477
- Testing
- Diet
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Boston Children's Hospital
Cardiovascular Diseases, Heart Diseases
Heritage Study--Genetics, Exercise and Risk Factors
To document the role of the genotype in the cardiovascular and metabolic responses to aerobic exercise-training and the contribution of inherited factors in the changes brought about by regular exercise for several cardiovascular…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Diabetes Mellitus, Non-insulin Dependent, Diabetes Mellitus
- Trial name
- HERITAGE (NCT00005137)
- Testing
- exercise program
- Sponsor
- Washington University School of Medicine
Obesity & Overweight, Cardiometabolic Risk Factors
Pilot Test of Five Weight Neutral Interventions to Improve Health Among Adults of Higher Body Weight
The purpose of this research study is to pilot test five different, group based and remotely delivered programs designed to support healthy eating and regular physical activity.
- Trial name
- NEW PATH (NCT07363616)
- Testing
- Mediterranean eating style, Physical activity, Mindful Eating
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Gestational Diabetes Mellitus (GDM)
Tianjin Gestational Diabetes Prevention Program (TGDPP)
A total of 1,180 women diagnosed with Gestational Diabetes Mellitus (GDM) from 2005 to 2009 and their children have and continues to be randomly assigned to either the intervention group or the control group.
- Trial name
- GDM (NCT01554358)
- Testing
- Lifestyle intervention
- Where
- China
- Volunteers
- 2,526 people, healthy volunteers welcome
- Sponsor
- Tianjin Women and Children's Health Center
Osteoporosis
Exercise as an Modulator of Immunological Risk Factors for Osteoporosis
This is the second phase of a study designed to determine the immunological effects of long-term exercise on risk factors for ischemic heart disease (phase 1) and osteoporosis (phase 2).
- Trial name
- NCT02765945
- Testing
- Supervised exercise program
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Diabetes, Depression
INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) Study
To provide better care and preventive services for people with both depression and diabetes, the investigators propose to develop and test whether interventions to reduce depressive symptoms can be integrated into routine…
- Conditions
- Diabetes, Depression, Cardiovascular Risk Factor
- Trial name
- INDEPENDENT (NCT02022111)
- Testing
- Patient Education and Behavioral Activation, Supporting Self-Care (care coordinators), Psychiatrist and Diabetologist Reviews
- Where
- 4 sites in India
- Volunteers
- 404 people
- Sponsor
- Emory University
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