Clinical trials: Metabolic Syndrome, Atherosclerosis
Asthma, Atherosclerosis
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Background: Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation.
- Conditions
- Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01143480
- Where
- United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Metabolic Syndrome
Effect of Aged Garlic Extract on Atherosclerosis
The investigators will be assessing the effect of Aged Garlic Extract on the coronary arteries. The investigators will enroll patients in a double blind study, where half the patients will receive placebo, and have the patients…
- Trial name
- Garlic4 (NCT01534910)
- Testing
- aged garlic extract
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Atherosclerosis of Artery, Metabolic Syndrome
Carotid Atherosclerotic Plaque Load and Neck Circumference
The aim of this study is to establish a deep learning model to automatically detect the presence and scoring of carotid plaques in neck CTA images, and to determine whether this model is compatible with manual interpretations.
- Conditions
- Atherosclerosis of Artery, Metabolic Syndrome, Machine Learning
- Trial name
- NCT05040958
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Pediatric Obesity, Metabolic Syndrome
Cardio-Metabolic Risk Evaluation in Overweight and Obese Children
Metabolic and cardio-vascular complications can often appear in overweight and obese children from an early age. Currently, there are few studies in the specialized literature that correlate clinical, biological and ultrasound…
- Conditions
- Pediatric Obesity, Metabolic Syndrome, Nonalcoholic Fatty Liver, Atherosclerosis
- Trial name
- CardMetSOb (NCT05908877)
- Testing
- History and Clinical evaluation, Biological evaluation of the metabolic syndrome and components, Ultrasound evaluation of subclinical atherosclerosis and visceral fat storage
- Where
- Romania
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Neoped - Centru de Pediatrie
Diabetes Mellitus, Metabolic Syndrome
Effect of Bariatric Surgery "Digestive Adaptations III" on Cardiovascular Risk
Introduction- Primary prevention is the main strategy to control the global burden of cardiovascular disease. In clinical practice, food restriction represents a valuable preventive resource.
- Conditions
- Diabetes Mellitus, Metabolic Syndrome, Obesity, Atherosclerosis
- Trial name
- ADIII (NCT01581099)
- Testing
- Digestive Adaptations III surgery
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Metabolic Syndrome, Atherosclerosis
Risk Factor Analysis for Developing Metabolic Syndrome in Korean Adults
In Asia, the prevalence of metabolic syndrome have been dramatically increased. Therefore, the investigators intend to the collect the blood sample, laboratory, anthropometric, and body composition parameters prospectively to…
- Trial name
- NCT01594710
- Where
- South Korea
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Korea University
Insulin Resistance, Atherosclerosis
Human Atherosclerotic Plaque Inflammation Imaged Using PDG-PET/CT
People with diabetes are at increased risk for atherosclerosis and have high CVD morbidity and mortality rates. Tools for detecting and quantifying atherosclerotic pro/regression in people with diabetes and other CVD risk factors…
- Conditions
- Insulin Resistance, Atherosclerosis, Cardiovascular Disease, HIV/AIDS
- Trial name
- NCT00958815
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Atherosclerosis, Metabolic Syndrome
The Effect of Sitting and Moderate Exercise on Plasma Triglyceride Elevation After a Meal
The purpose of this study is to investigate the effect of 4 days of sitting and moderate exercise on plasma triglyceride elevation after a meal.
- Trial name
- NCT03098446
- Testing
- Prolonged sitting with exercise, Prolonged sitting without exercise
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Atherosclerosis, Obesity
Vascular Inflammation Stratified by Body Size Phenotype
Vascular Inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18FDG-PET is a promising novel tool for identifying and quantifying vascular inflammation within atherosclerotic plaque Recently…
- Conditions
- Atherosclerosis, Obesity, Metabolic Syndrome
- Trial name
- NCT01979068
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Korea University
Metabolic Syndrome, Coronary Heart Disease
Hämeenlinna Metabolic Syndrome Research Program: Surrogate Indicators for Atherosclerosis
Mechanisms that link metabolic syndrome to atherosclerosis are incompletely understood. As a part of Hämeenlinna Metabolic Syndrome Research Program (HMS) surrogate indicators for atherosclerosis are studied in 120 men with…
- Trial name
- HMS-02 (NCT01119404)
- Where
- 4 sites in Finland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kanta-Häme Central Hospital
Hyperlipidemia, Metabolic Syndrome X
Low Fat Plant-Based Supplemented Diet Effects on Risk Factors for Chronic Non-communicable Diseases
The effect of a diet free from animal-sourced nutrients on a variety of risk factors for chronic non-communicable diseases in weight reduction programs is not well established.
- Trial name
- LFPBDS2 (NCT02905448)
- Testing
- Low fat plant-based nutrition
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Barbara Jakše s.p.
Metabolic Syndrome
Olive Oil and Nampt on Postprandial Inflammation and Atherosclerosis in the Setting of Metabolic Syndrome
The metabolic syndrome may be defined as the constellation of cardiovascular disease (CVD) risk factors that comprises obesity, type 2 diabetes, dyslipidemia, and hypertension.
- Trial name
- OLNAMS (NCT02061267)
- Testing
- Niacin, Saturated meal, Monounsaturated meal
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Atherosclerosis Cardiovascular Disease, Metabolic Syndrome
Comparative Effects of Carnivore and Mediterranean-style Diets on LDL Aggregation and Cardiometabolic Health
The goal of this clinical trial is to learn whether following a Mediterranean-style diet or a Carnivore-style diet can improve heart and metabolic health in men and women aged 30-60 years with high LDL cholesterol.
- Conditions
- Atherosclerosis Cardiovascular Disease, Metabolic Syndrome, Dyslipidaemia
- Trial name
- MEDIVORE (NCT07462871)
- Testing
- Carnivore Diet, Mediterranean Diet
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Cardiovascular Diseases, Diabetes
Kuopio Ischaemic Heart Disease Risk Factor Study (Nutrition Component)
To determine associations between dietary factors and risk of major chronic diseases and their risk factors
- Conditions
- Cardiovascular Diseases, Diabetes, Metabolic Syndrome, Cancer
- Trial name
- NCT03221127
- Volunteers
- 2,682 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Atherosclerosis Cardiovascular Disease, Obesity
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.
This study aims to investigate how moderate wine consumption influences circulating extracellular vesicles (EVs) in healthy adults.
- Conditions
- Atherosclerosis Cardiovascular Disease, Obesity, Metabolic Syndrome, Metabolic Disorders
- Trial name
- (WINEVOME) (NCT07361887)
- Testing
- White Wine, Red Wine, Water
- Where
- Spain
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Seville
Metabolic Syndrome, Obesity
Dietary Modulation of Gene Expression and Metabolic Pathways in Glucose Metabolism
Professor Matti Uusitupa, University of Kuopio, Department of Clinical Nutrition (www.uku.fi) Docent Matej Oresic, VTT (www.vtt.fi) Ursula Schwab, PhD, Docent, Marjukka Kolehmainen, PhD, Docent, Leena Pulkkinen, PhD, Docent…
- Conditions
- Metabolic Syndrome, Obesity, Impaired Glucose Tolerance, Impaired Fasting Glucose
- Trial name
- Sysdimet (NCT00573781)
- Testing
- Diet with increased intake of rye bread, berries and fish, Increased intake of whole grain and rye bread, Control diet with decreased intake of rye bread, berries and fish
- Where
- Finland
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Hypopituitarism, Pituitary Tumors
Effect of 5 Years of GH Replacement on Atherosclerosis
Adult patients with hypopituitarism under adequate conventional hormone replacement therapy have reduced life expectancy due to excess vascular events (1-4).
- Conditions
- Hypopituitarism, Pituitary Tumors, Growth Hormone Deficiency
- Trial name
- 5yrGH (NCT00462475)
- Testing
- Recombinant Growth Hormone, Genotropin (Pfizer)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
HIV Infections, Lipodystrophy
Observational Study of Changes in Fat Distribution and Blood Metabolites in HIV Infected Adults
The purpose of this study is to collect data on the body's breakdown of sugar and fat in HIV infected adults. Data from this study will make clearer the roles of HIV infection and anti-HIV drugs in the development of diabetes…
- Conditions
- HIV Infections, Lipodystrophy, Diabetes, Hyperlipidemia
- Trial name
- NCT00331448
- Volunteers
- 1,483 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Carotid Atherosclerosis, Stroke
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque
The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor…
- Conditions
- Carotid Atherosclerosis, Stroke, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT00636766
- Testing
- atorvastatin, rimonabant, rosiglitazone
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Metabolic Syndrome X, Atherosclerosis
The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia
The purpose of this study is to investigate the effect of interrupting prolong sedentary behavior with interval exercise on postprandial metabolism following a high fat glucose tolerance test.
- Conditions
- Metabolic Syndrome X, Atherosclerosis, Insulin Resistance, Hyperinsulinism
- Trial name
- NCT03856606
- Testing
- Prolonged sitting without exercise, Prolonged sitting with interval exercise
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin