Clinical trials: Metabolic and Nutritional Disorders
Caries,Dental, Caries Root
Coronal and Radicular Caries Prevalence and Related Risk Factor in Diabetic Patient
This study aims to investigate the prevalence and risk factors of coronal and radicular caries in middle-aged individuals with Type 2 diabetes.
- Conditions
- Caries,Dental, Caries Root, Diabetes Mellitus, Type 2
- Trial name
- NCT06701565
- Volunteers
- 265 people
- Sponsor
- Cairo University
Diabetes Mellitus, Type 2
Safety Assessment of Lyxumia (Lixisenatide) and Sulfonylurea as Add-on Treatment to Basal Insulin in Uncontrolled Patients With Type 2 Diabetes Mellitus Who Elect to Fast During Ramadan
Primary Objective: To compare the safety, in terms of percentage of patients with symptomatic documented hypoglycemia during Ramadan fast, of lixisenatide versus sulfonylurea (SU).
- Trial name
- LixiRam (NCT02941367)
- Testing
- Lixisenatide (AVE0010), Sulfonylurea, metformin
- Where
- 16 sites in India, Israel and 2 more
- Volunteers
- 184 people
- Sponsor
- Sanofi
Transgender, Gender Identity
Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Men
This study will examine markers of vascular endothelial function (vascular health) and metabolic profiles in older versus younger transgender men (people who were assigned female at birth but whose gender identity is male).
- Conditions
- Transgender, Gender Identity, Vascular Stiffness, Vascular Inflammation
- Trial name
- NCT04237467
- Testing
- No intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy, Obesity
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the…
- Trial name
- GHRB-B (NCT06571500)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Obesity, Insulin Resistance
Eosinophils in Human Adipose Tissue
The purpose of this study is to better understand the interactions between the innate immune system, in particular eosinophils (EOS), and adipose tissue (AT) in human health and in disease states such as obesity and insulin…
- Trial name
- NCT04898400
- Testing
- endoscopy sleeve gastroplasty
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Diabetes
Ambulance 'Hypos Can Strike Twice' Study
This study will assess the effectiveness the "Hypos can strike twice" intervention on people with diabetes experiencing hypoglycaemia (or "hypo", meaning low blood sugar).
- Trial name
- Ambu-HS2 (NCT04243200)
- Testing
- Hypos can strike twice
- Where
- United Kingdom
- Volunteers
- 5,015 people
- Sponsor
- University of Lincoln
Metabolic Syndrome
Glucagon-like Peptide 1 (GLP-1) and Endothelial Dysfunction in Metabolic Syndrome
Glucagon-like peptide 1 (GLP-1) is an intestinal peptide hormone secreted in a nutrient-dependent manner that stimulates the pancreatic beta cells to secrete more insulin in response to the same amount of blood glucose.
- Trial name
- NCT00856700
- Testing
- GLP-1 infusion
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Rome Tor Vergata
Obesity, Intestinal Bacteria Flora Disturbance
Study on Dietary Nutrition Intervention Techniques for Children Obesity
With the rapid development of society and economy, children's simple obesity is the rising in the world and has become a chronic disease which is one of the biggest public health challenges in the world.
- Conditions
- Obesity, Intestinal Bacteria Flora Disturbance, Body Weight
- Trial name
- NCT02539836
- Testing
- Dietary nutrition based on plant fermentation extract, MRI in quantifying liver fat with MRS
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Diabetes, Hypertension
Study of Medical Assistant Health Coaching in Primary Care for Patients With Chronic Conditions
Randomized control trial studying the effect of medical assistant health coaching for patients with diabetes, hypertension and hyperlipidemia within two San Francisco primary care community clinics, Mission Neighborhood Health…
- Conditions
- Diabetes, Hypertension, Hyperlipidemia
- Trial name
- HCPC (NCT01220336)
- Testing
- Health coaching by medical assistants in primary care
- Where
- 2 sites in United States
- Volunteers
- 441 people
- Sponsor
- University of California, San Francisco
Fasting, Dietary Fibre
Combining Fasting and Fibre Interventions to Optimise Their Gut Microbiome-mediated Health Benefits
This study builds on the knowledge that fasting provides metabolic health benefits and that prebiotic interventions can enhance the gut microbiome's metabolic output to likewise improve host health.
- Conditions
- Fasting, Dietary Fibre, Gut Microbiome, Metabolism Changes
- Trial name
- CoFFIe (NCT07691736)
- Testing
- Fibre Arm, Control Arm
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Buchinger Wilhelmi Development & Holding GmbH
Obesity
Rural Engagement in Primary Care for Optimizing Weight Reduction
The purpose of this study is to compare three methods for managing obesity in rural patients, to see which method will result in patients being able to attain their weight loss goal and maintain that weight loss.
- Trial name
- RE-POWER (NCT02456636)
- Testing
- Fee-for-Service Model (FFS, In clinic individual visits), Patient Centered Medical Home (PCMH, In clinic group visits), Disease Management (DM, Phone group visits)
- Where
- United States
- Volunteers
- 1,432 people
- Sponsor
- University of Kansas Medical Center
Obesity, Hypertension
Serum CTRP3 and RBP4 Levels in Obesity and Hypertension
Insulin resistance is closely correlated with obesity and cardiovascular disease. Adipokines may play important roles in the pathogenesis of obesity, which are a link between obesity and obesity-related disorders.C1q/TNF-related…
- Trial name
- NCT02226471
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Diabetic Neuropathies, Diabetes Mellitus
Efficacy and Safety of the Combination of Ten Elements for 6 Months in Patients With Diabetic Neuropathy : A Pilot Study
To investigate the efficacy of Superoxide Dismutase (SOD, 70 UI), Palmitoylethanolamide (PEA, 300 mg) Alpha Lipoic Acid (ALA, 300 mg), vitamins B6 (1.5 mg), B1 (1.1 mg), B12 (2.5 mcg), E (7.5 mg), Nicotinamide (9 mg) and minerals…
- Conditions
- Diabetic Neuropathies, Diabetes Mellitus, Dietary Supplement
- Trial name
- NCT05984771
- Testing
- Epineuron
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- Aristotle University Of Thessaloniki
Vitamin D Deficiency
Effects of Antarctic Environment on Vitamin D Status and Health Risk Biomarkers of Its Inhabitants
The purpose of this study is to evaluate vitamin D (VD) deficiency in the population of Chilean Antarctica and evaluate the efficacy and safety of VD supplementation to decrease VD deficiency and favorably influence biomarkers…
- Trial name
- AntarD (NCT02930434)
- Testing
- cholecalciferol
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Cardiovascular Diseases, Hyperlipidemia
Home-based Exercise for Management of HIV-associated Cardiovascular Disease Risk
Because of advances in drug treatment, people living with HIV/AIDS (PLWHA) are living longer, but are also at greater risk for cardiovascular disease (CVD) and diabetes.
- Conditions
- Cardiovascular Diseases, Hyperlipidemia, Obesity
- Trial name
- NCT01377064
- Testing
- Physical Activity Group, Standard Care Group
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of South Carolina
Diabetes
Evaluating the User Performance and Experience of Nucleus Pen vs. Commercially Available Pen Needle
This is a multi-site, prospective, open-label, randomized, 2 period cross over study comparing the subjects' current 32G pen needle (four groups of pen needles) to the BD Nucleus pen needle.
- Trial name
- NCT03267264
- Testing
- BD Nano™ vs Nucleus, NovoFine® vs Nucleus, NovoTwist®/NovoFine® Plus vs Nucleus
- Where
- 4 sites in United States
- Volunteers
- 248 people
- Sponsor
- Becton, Dickinson and Company
Obesity
Probiotic for Weight Management in Overweight and Obese Adults
To evaluate the impact of pasteurized Akkermansia muciniphila Akk11 capsules versus placebo on body composition (including body weight, BMI, body fat percentage, waist-to-hip ratio, wrist circumference, visceral fat area, and…
- Trial name
- NCT07507929
- Testing
- Probiotic
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Phenylketonuria
A Study of JNT-517 in Participants With Phenylketonuria (PKU)
This Phase 3 study will evaluate the safety, effectiveness, tolerability, and how the body processes JNT-517 in children, adolescents, and adults with phenylketonuria.
- Trial name
- NCT06971731
- Testing
- JNT-517
- Where
- 26 sites in United States, Australia and 8 more
- Volunteers
- 120 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Pediatric Obesity
Developing a Preschool Obesity Intervention for Families Enrolled in WIC
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a community and home-based preschool obesity intervention for families enrolled in the Special Supplemental Nutrition Program for…
- Trial name
- NCT02292602
- Testing
- Family-Based Weight Control
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Wayne State University
Diabetes
An Inpatient Evaluation of Six-Day Subcutaneous Glucose Sensor Performance
The purpose of this study is to assess the performance of the subcutaneous glucose sensor over an extended sensor life. The sensor is currently approved for 3 days of use and this study will examine sensor safety and accuracy…
- Trial name
- 6-DayFU (NCT00865345)
- Testing
- MMT-7003 subcutaneous glucose sensor
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- Medtronic MiniMed, Inc.
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