Clinical trials: Metabolic and Nutritional Disorders
Obesity
Cross Calibration of Two Dual Energy Densitometers and Comparison of Regional Adipose Tissue Measurements by iDXA and MRI
Background: It is important for doctors to know how much fat a person has in his or her body. Machines called DXAs measure how much fat mass and fat-free mass a person has.
- Trial name
- NCT02346474
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
HCT Cash-Only INcentive to Promote Mealtime Insulin DOSE Engagement
Type 1 Diabetes (T1D) is a serious disease that happens because the body cannot control blood glucose (sugar) levels. People with T1D need insulin shots because their body does not make insulin. Insulin lowers blood sugar levels.
- Trial name
- NCT04621890
- Testing
- LOAN2DOSE and COIN2DOSE
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Children's Mercy Hospital Kansas City
Hypercholesterolemia
MK0653A (Ezetimibe (+) Simvastatin) Compared to an Approved Drug (Atorvastatin) for the Treatment of High Cholesterol (0653A-051)(COMPLETED)
This study is to assess the safety and efficacy of an investigational drug as compared to an approved drug to reduce specific cholesterol levels.
- Trial name
- NCT00092690
- Testing
- MK0653A, ezetimibe (+) simvastatin, Comparator: atorvastatin
- Volunteers
- 1,902 people
- Sponsor
- Organon and Co
Type 1 Diabetes Mellitus
Feasibility and Efficacy of Delivering Blood Glucose Awareness Training Over the Internet
BGATHome is an interactive, web-based training program designed to improve the ability of adults with Type 1 Diabetes to recognize, predict, treat, and avoid extreme blood glucose (BG) events.
- Trial name
- NCT00327210
- Testing
- Blood Glucose Awareness Training
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Virginia
Cardiovascular Diseases, Heart Diseases
Strong Heart Study Analyses Obesity and Lipoproteins
To examine the relationship of obesity and body fat distribution to lipoprotein concentrations in members of the Strong Heart Study.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Obesity
- Trial name
- NCT00005510
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Type 1 Diabetes
Effect of CGM With Predictive Alarm on Hypoglycemia in Young Patients With T1D.
The use of continuous glucose monitoring (CGM) is becoming the new standard in glycometabolic control in patients with Type 1 Diabetes Mellitus (T1DM) even in subjects in multiple daily insulin injections (MDI).
- Trial name
- CGMHYPO (NCT05574023)
- Testing
- Use of Predictive Alarm for hypoglycaemia or hyperglycaemia, Use of Alarm on Threshold for hypoglycaemia or hyperglycaemia
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
A Phase 2b Study of Zagociguat in Patients With MELAS
PRIZM is a Phase 2b randomized, double-blind, placebo-controlled, 3-treatment, 2-period, crossover study evaluating the efficacy and safety of oral zagociguat 15 and 30 mg vs.
- Trial name
- PRIZM (NCT06402123)
- Testing
- zagociguat 15mg, zagociguat 30mg
- Where
- 20 sites in United States, Australia and 4 more
- Volunteers
- 43 people
- Sponsor
- Tisento Therapeutics
Dyslipidemia
12-Month, Open-Label, Extension Study of LCP-AtorFen in Dyslipidemia
The current study is designed to test the long-term (12-month) safety and efficacy of LCP-AtorFen, a combination of atorvastatin and fenofibrate, in patients with dyslipidemia
- Trial name
- NCT00664859
- Testing
- LCP-AtorFen
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Veloxis Pharmaceuticals
Coronary Artery Disease, Diabetes Mellitus
Reservoir-Based Polymer-Free Amphilimus-Eluting Stent Versus Polymer-Based Everolimus-Eluting Stent in Diabetic Patients
This study is a prospective, randomized controlled, single blind, two-arm, multicenter clinical evaluation. Diabetic patients (n=112) with de novo coronary artery disease will be randomized to one of the 2 treatment arms: 1)…
- Trial name
- RESERVOIR (NCT01710748)
- Testing
- Polymer-Based Everolimus-Eluting Stent, Polymer-Free Amphilimus-Eluting Stent
- Where
- 4 sites in Spain
- Volunteers
- 112 people
- Sponsor
- Spanish Society of Cardiology
Obstructive Sleep Apnea, Obesity
Consequences of Obstructive Sleep Apnea on Respiratory Function Following Weight-loss Surgery
The investigators propose to compare two different treatments, continuous positive airway pressure (CPAP) versus breathing of atmospheric pressure, in subjects with obstructive sleep apnea (OSA)recovering from weight loss surgery…
- Trial name
- NCT01697878
- Testing
- CPAP followed by atmospheric pressure, Atmospheric pressure followed by CPAP
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Diabetic Ketoacidosis
Diabetic Ketoacidosis: Brain Morphology and Cognition
The purpose of this study is to assess brain and memory changes in patients with uncontrolled diabetes (a condition called diabetic ketoacidosis (DKA))
- Trial name
- DKA-Cog (NCT02443415)
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Type 2 Diabetes Mellitus
A Study to Assess the Efficacy and Safety of ASP1941 in Combination With Sulfonylurea in Type 2 Diabetic Patients
This study is to evaluate the efficacy and safety after concomitant administration of ASP1941 and sulfonylurea in patients with diabetes mellitus.
- Trial name
- NCT01242215
- Testing
- ipragliflozin, Sulfonylurea
- Where
- 7 sites in Japan
- Volunteers
- 243 people
- Sponsor
- Astellas Pharma Inc
Type 2 Diabetes
A Relative Bioavailability Study of HRS9531 in Healthy Subjects
The purpose of this study is to evaluate the relative bioavailability of the new formulation of HRS9531 injection between the original formulation of HRS9531 injection.
- Trial name
- NCT05893576
- Testing
- HRS9531
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Fetal Heart Rate Variability
Fetal Evaluation at Term Using Statistical ECG Signal Processing (FETUSES)
Background The fetal heart rate (FHR) is commonly monitored during labor to detect early fetal acidosis. FHR variability is traditionally investigated using Fourier transform, however, fetal conditions differ from adults (higher…
- Trial name
- FETUSES (NCT02835417)
- Volunteers
- 3,563 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Overweight
PILI at Work a 5-Year Controlled Intervention Trial: Testing DVD Versus Group Delivery of a Weight-Loss Maintenance Intervention in Native Hawaiian- Serving Worksites
The PILI @ Work project is a 5 year randomized control trial to adapt a weight loss program for the employees of Native Hawaiian-serving organizations in Hawai'i.
- Conditions
- Obesity, Overweight, Weight Loss, Weight Loss Maintenance
- Trial name
- P@W (NCT01652989)
- Testing
- Weight loss maintenance intervention face-to-face, Weight loss maintenance intervention delivered via DVD
- Where
- 8 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Hawaii
Healthy, Diabetes Type 2
Assessment of Three Instruments for the Non-invasive Measurement of Arterial Stiffness.
The ASI Non-Invasive Arterial Stiffness Screening Device (ASI Device) is an investigational device under development for the non-invasive assessment of arterial stiffness.
- Conditions
- Healthy, Diabetes Type 2, Obesity, Coronary Artery Disease
- Trial name
- ASI-2012 (NCT01722474)
- Testing
- ASI Device
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Type 2 Diabetes, Chronic Kidney Disease
Sweet & Sour: Dietary Acid Load in Type 2 Diabetes and Kidney Disease Across Sex and Ethnic Groups
Chronic kidney disease (CKD) is a common condition and a major global cause of illness and mortality. The most common cause of kidney damage is diabetes, a condition that disrupts metabolism, leading to increased risk of damage…
- Trial name
- Sweet & Sour (NCT07587918)
- Testing
- Low Dietary Acid Load
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Erasmus Medical Center
Diabetes Mellitus, Type II
Diabetes Mellitus Type II and Tissue Oxygenation
The purpose of this study is to determine whether diabetics have decreased amounts of oxygen in the skin compared to non-diabetic individuals, and if the amount of oxygen in the skin changes when given more oxygen to breathe…
- Trial name
- NCT00554697
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Diabetes Mellitus, Type 2
Effect of LY2189265 on Insulin Secretion in Response to Intravenous Glucose
The purpose of this study is to measure the effect of LY2189265 to increase insulin levels in response to glucose intake.
- Trial name
- NCT01300260
- Testing
- LY2189265, Insulin, Glucose
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Diabete Type 2
Effect of a Healthy Food Voucher on Blood Glucose Control in People With Type 2 Diabetes or Prediabetes
This randomized controlled trial (RCT) will determine if access to a voucher for healthy foods reduces blood sugar levels among people living on a low income who have type 2 diabetes or elevated blood sugar.
- Trial name
- VOUCH4DIABETES (NCT05776420)
- Testing
- Food voucher
- Where
- Canada
- Volunteers
- 390 people
- Sponsor
- Unity Health Toronto
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.