Clinical trials: Metabolic and Nutritional Disorders
Type 2 Diabetes Mellitus, Cardiovascular Abnormalities
Curcumin for Type 2 Diabetic Patients
There are evidence that there is an association between insulin resistance and prolonged hyperinsulinemia or hyperglycemia in Type 2 diabetic patients.
- Trial name
- NCT01052597
- Testing
- curcumin
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Srinakharinwirot University
Obesity
The Effect of 5-Hydroxytryptophan (5-HTP) on Satiety
The aim of the study is to show evidence of the efficacy of 5-HTP to induce satiety and to reduce food intake (confirmatory study).
- Trial name
- NCT00328913
- Testing
- 5-hydroxytryptophan (food supplement)
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Obesity
Effects of HMOs on the Faecal Microbiota and on Host Metabolism in Obese Children
The study is a randomised, placebo-controlled, double-blind, parallel study in obese children. A total of 75 obese children in the age 5 to 10 years, enrolled in a childhood obesity treatment program, will be included.
- Trial name
- NCT02786160
- Testing
- HMO, Dextropur
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Glycom A/S
Diabetes, Gestational
Insulin Sensitivity and Secretion During Pregnancy and Post Partum in Women With Gestational Diabetes.
Aim of the study: To define insulin requirement during pregnancy and to identify the rapid changes in insulin sensitivity around parturition and the first 6 months post partum.
- Trial name
- NCT02770079
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Epilepsy, Trauma
Comparison of Oral 30 % Dextrose and iv Midazolam Sedation During MRI in Neonates
The purpose of this study is to demonstrate the effectiveness of oral glucose administration during MRI for imaging of newborns and compare with midazolam sedation.
- Conditions
- Epilepsy, Trauma, Metabolic Disease
- Trial name
- NCT02645279
- Testing
- oral 30% glucose, IV midazolam
- Volunteers
- 112 people
- Sponsor
- Baskent University
Colorectal Cancer
FITting Non-invasive Tests in Lynch Syndrome Surveillance
The purpose of this clinical study is to evaluate the accuracy of the fecal immunochemical test (FIT) in comparison to colonoscopy in patients with Lynch Syndrome (LS) who are undergoing colonoscopy surveillance.
- Trial name
- NCT06898996
- Testing
- Fecal immunochemical test
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of Chicago
Hepatic Encephalopathy
Efficacy and Safety of Nifuroxazide in the Treatment of Hepatic Encephalopathy in Egyptian Patients With Liver Cirrhosis
This is a pilot study designed to evaluate the efficacy and safety of nifuroxazide in the treatment of hepatic encephalopathy in patients with grade II-III hepatic encephalopathy
- Trial name
- NCT05754996
- Testing
- Nifuroxazide, Lactulose, Rifaximin 550Mg Tab
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Type 2 Diabetes
Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of Ultra Low Doses of Dapagliflozin in Healthy Subjects
The purpose of this study is to evaluate the pharmacodynamics (PD), pharmacokinetics (PK), safety and tolerability following single oral doses of 0.001 mg to 2.5 mg dapagliflozin in healthy subjects.
- Trial name
- ULDS (NCT01135446)
- Testing
- dapagliflozin
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Overweight, Obesity
Longevity Diet and the Fasting-mimicking Diet
This retrospective clinical study examines the impact of the longevity diet and fasting-mimicking diet (FMD), either alone or combined, on body composition and health indicators.
- Conditions
- Overweight, Obesity, Metabolic Syndrome, Autoimmune Diseases
- Trial name
- NCT07065955
- Testing
- Longevity diet alone or in combination with fasting mimicking diet
- Where
- Italy
- Volunteers
- 365 people
- Sponsor
- Fondazione Valter Longo
Type 1 Diabetes, Quality of Life
Randomized Crossover Study to Test the Impact of Using a Software for Smartphones and Tablets in Treating Type 1 Diabetes
The purpose of this study is to evaluate the impact of a software for smartphones and tablets on type 1 diabetes control and quality of life
- Conditions
- Type 1 Diabetes, Quality of Life, Hypoglycaemia
- Trial name
- NCT02107326
- Testing
- Webdia Software
- Where
- Switzerland
- Volunteers
- 55 people
- Sponsor
- Philippe Klee
Type 2 Diabetes (T2DM)
Evaluate the Efficacy and Safety of GZR33 Injection in Patients With Type 2 Diabetes
Evaluate the efficacy of GZR33 Injection and Insulin Degludec Injection (Tresiba®) in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Oral Antidiabetic Drugs.
- Trial name
- NCT07527078
- Testing
- GZR33 Injection, Insulin Degludec Injection (Tresiba®)
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Vitamin D Deficiency
Isolation of Vitamin D Binding Protein Isoforms From Human Volunteers
The purpose of this study is to isolate genotype-specific DBP/Gc from homozygous human volunteers and use these purified proteins to cross-validate existing or novel assays for this serum protein and to evaluate the binding…
- Trial name
- NCT02258035
- Testing
- Blood draw
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diabetes Mellitus, Type 2
Effect of Bile Acid Secretion and Sequestration on GLP-1 Secretion
Accumulating evidence suggests that bile acids in our intestines may constitute essential components in the complex mechanisms regulating gut hormone secretion and glucose homeostasis.
- Trial name
- NCT02445508
- Testing
- Sevelamer, Cholecystokinin, Isotonic saline
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Breast Cancer
4:3 Intermittent Fasting Intervention in Adults With Breast Cancer and Overweight or Obesity
This is a 3 month single arm pilot and feasibility study designed to examine the impact of an intermittent fasting lifestyle weight loss intervention on pre-specified clinical milestones (change in body weight, adherence to the…
- Trial name
- NCT06399276
- Testing
- Weight Loss
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- University of Colorado, Denver
Anemia, Iron Deficiencies
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CTX001 in Healthy Adults.
This study is testing CTX001 for certain conditions where the body does not have enough available iron or has difficulty storing or moving iron properly.
- Conditions
- Anemia, Iron Deficiencies, Chronic Kidney Disease
- Trial name
- NCT07577817
- Testing
- CTX001 With and Without Iron, CTX001 With Iron, CTX001 Multiple Dose
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cajal Therapeutics Inc.
Neuro-Degenerative Disease, Dementia
Decreased Empathy and Emotion Recognition in Patients With Neurodegenerative Disease
This study evaluates an educational brochure tailored to caregivers of people with Alzheimer's disease, Parkinson's disease dementia, Lewy body disease, frontotemporal dementia, and vascular disease dementia.
- Conditions
- Neuro-Degenerative Disease, Dementia, Caregiver Burnout, Alzheimer Disease
- Trial name
- Empathy (NCT04635540)
- Testing
- Educational Brochure
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- University Health Network, Toronto
Diabetes, Diabetes Mellitus, Type 2
A Trial to Assess the Pharmacokinetics, Safety and Tolerability of Semaglutide in Healthy Chinese Subjects
The main purpose of the trial is to assess the pharmacokinetics of semaglutide (i.e. the way the drug is distributed in the body over a period of time) following once-weekly administration of semaglutide in healthy Chinese…
- Trial name
- NCT03288740
- Testing
- Semaglutide 0.5 mg, Semaglutide 1.0 mg
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
PreDiabetes, Type 2 Diabetes Mellitus
Is the Degree of Perceived Effort During Resistance Exercise Important for Improvements in Blood Glucose
The goal of this clinical trial is to compare the degree of effort during a resistance exercise session on blood glucose levels in individuals with prediabetes or type 2 diabetes mellitus.
- Trial name
- NCT06208189
- Testing
- High-effort session, Low-effort session, Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of New Mexico
Overweight, Obesity
Nutrition, Exercise, and Technology for Weight Loss
The purpose of this study is to evaluate whether a social support-enhanced, technology-based, behavioral weight control intervention can improve weight loss over existing best practices.
- Trial name
- NCT02731768
- Testing
- Standard, Social support-enhanced, Fitbit Zip
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Homozygous Familial Hypercholesterolemia (HoFH)
A Long-term Follow-up Study to Evaluate the Safety and Efficacy of RGX-501
This long-term observational study is designed to follow subjects who, during another Clinical Study, received gene therapy treatment used to treat their Homozygous Familial Hypercholesterolemia (HoFH) disease.
- Trial name
- NCT04080050
- Testing
- Single intravenous (IV) dose of human Low Density Lipoprotein Receptor (LDLR) Gene Therapy
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 8 people
- Sponsor
- REGENXBIO Inc.
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