Clinical trials: Metabolic and Nutritional Disorders
Obesity
Cryoablation for Obesity Management
The purpose of this study is to assess the efficacy of cryoablation therapy for the treatment of mild to moderate obesity and test the safety (good and bad effects) of this procedure.
- Trial name
- NCT03092778
- Testing
- Cryoablation
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Type 2 Diabetes Mellitus
Evaluation of Low Blood Sugar Events in Participants With Diabetes (MK-0431-402)
This is a multicenter, observational, retrospective and cross-sectional study to be conducted in a cohort of consecutively selected participants with type 2 diabetes mellitus (T2DM) who have been treated with sulphonylurea (SU)…
- Trial name
- NEEDS (NCT01278485)
- Testing
- Sulphonylurea, Metformn
- Volunteers
- 726 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes
Empowerment and Support for the Diabetic Patient
CHANGE-D objectives are to evaluate to what extent personal coaching for healthy lifestyle and treatment adherence improves clinical outcomes among uncontrolled diabetic patients.
- Trial name
- CHANGE-D (NCT02179385)
- Testing
- Health Coaching
- Volunteers
- 300 people
- Sponsor
- Clalit Health Services
Overweight and Obesity
The Effect of Supplementation With Species of Lactobacillus on Anthropometric Measurements
The investigators aimed to study the effect of supplementation with species of Lactobacillus on anthropometric measurements, body composition, appetite and serum lipid profile in overweight and obese adults
- Trial name
- NCT02448940
- Testing
- Species of Lactobacillus, lactose
- Where
- Iran
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Urmia University of Medical Sciences
Liver Diseases
Metformin in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)
The purpose of this study is to examine the effect of metformin on biochemical and histological findings in NAFLD patients with insulin resistance syndrome.
- Trial name
- NCT00247117
- Testing
- Metformin
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Kaplan Medical Center
Plexus Choroideus, Metabolic Syndrome
Choroid Plexus Dysfunction in Neurological Diseases
Cerebral folate deficiency (CFD), a partially treatable condition defined by a low folate cerebrospinal fluid (CSF) concentration, can be linked to genetic defects of folate metabolism or be secondary to various diseases without…
- Trial name
- PLEXFOLD (NCT06403189)
- Testing
- Biologic samples and MRI
- Where
- 2 sites in France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies
Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy
The goal of this clinical trial is to learn if topical lidocaine gel can effectively reduce pain intensity compared to oral duloxetine in adult patients (aged 30-70 years) with type 2 diabetes suffering from painful diabetic…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies, Type 2 Diabetes
- Trial name
- NCT07800468
- Testing
- Topical Lidocaine 2% Gel, Duloxetine (60 MG)
- Volunteers
- 80 people
- Sponsor
- Wah Medical college , POF hospital
Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS)
IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion
The goal of this study is to learn how two treatments-adrenalectomy (surgical removal of an adrenal gland) and semaglutide (a medication used for weight management)-affect insulin resistance and cortisol regulation in adults with…
- Conditions
- Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS), Subclinical Cushing's, Mild Autonomous Cortisol Excess
- Trial name
- IMPACT-MACS (NCT07361874)
- Testing
- Intervention 1: Adrenalectomy, Intervention 2: Semaglutide
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes Mellitus
Single Hormone Closed Loop Study With PDT Sensor
The study described within this protocol is designed to test a single hormone closed-loop algorithm for managing blood glucose in type 1 diabetes using insulin only and a new device for measuring glucose continuously in the…
- Trial name
- NCT03528174
- Testing
- Artificial Pancreas Control system (APC), Pacific Diabetes Technologies CGM Insulin Infusion system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Overweight, Obesity
A Test of Nutritional Interventions to Enhance Weight Loss Maintenance
The purpose of this study is to compare standard Behavior Therapy (BT), BT plus Meal Replacements (MR) and a condition focusing on the nutritional changes to the home food environment (HFE) on weight loss, weight loss…
- Conditions
- Overweight, Obesity, Weight Loss Maintenance
- Trial name
- NCT01065974
- Testing
- Behavior Therapy, Meal Replacements, Nutritrol
- Where
- 2 sites in United States
- Volunteers
- 262 people
- Sponsor
- Drexel University
Diabetes Mellitus, Type 2, Prediabetic State
PREDICT-DM: Community Pharmacy-Based Point-of-Care Testing for Undiagnosed T2DM
The goal of this observational study is to learn whether community pharmacy-based risk assessment and point-of-care HbA1c testing can help detect undiagnosed type 2 diabetes and prediabetes among adults in Irbid Governorate…
- Conditions
- Diabetes Mellitus, Type 2, Prediabetic State, Prediabetes / Type 2 Diabetes, T2DM
- Trial name
- PREDICT-DM (NCT07795918)
- Where
- Jordan
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Kidney Transplant, Type 2 Diabetes
Sitagliptin Treatment in Patients With Type 2 DM After Kidney Transplant
This study is designed to look at the effect sitagliptin has on tacrolimus and sirolimus drug levels in kidney transplant patients. It is also designed to look at the side effects experienced in the transplant population.
- Trial name
- NCT00466518
- Testing
- Administration of sitagliptin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Oklahoma
Ischemia Limb, Diabete Mellitus
Comparative Study of Negative-Pressure Wound Therapy Integrated With Silver Nanoparticle Spray Versus Negative-Pressure Wound Therapy in Post-Revascularization Diabetic Foot Wound Management
This was a prospective, parallel-group, randomized controlled trial conducted at the Vascular Surgery Department of Kafrelsheikh University Hospital, Egypt.
- Trial name
- SNIPS-FOOT (NCT07147790)
- Testing
- After successful revacularization, We will categorize patients into two groups : groups A (The patient's wound will be cleaned and irrigated with silver nanoparticle spray, then we will cover the woun, Silver Nanoparticles Irrigant
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Kafrelsheikh University
Weight Loss, Starvation
Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
The purpose of this study is to determine if an increased protein intake can attenuate the suppression of metabolic and anabolic hormones during caloric restriction
- Trial name
- NCT02945410
- Testing
- Caloric Restriction, Protein, Exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Obesity (Disorder), Ventilation Homogeneity
Positional Effects on Lung Ventilation and Perfusion in Obesity
Electrical Impedance Tomography (EIT) is a non-invasive, bedside monitoring tool that provides real-time information on regional ventilation and perfusion.
- Conditions
- Obesity (Disorder), Ventilation Homogeneity, Perfusion, Ventilation Perfusion Mismatch
- Trial name
- NCT07341113
- Testing
- Standardized body positioning
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Koç University
Sarcopenic Obesity
Sarcopenic Obesity in Liver Transplanted Patients
The prevalence of obesity in cirrhotic patients who are candidates for liver transplantation (LT) is increasing, a phenomenon consistent with the increased prevalence of obesity in the general population.
- Trial name
- OSaLT (NCT05029713)
- Testing
- Evaluation of appendicular skeletal muscle mass (ASMM) by bioelectrical impedance analysis (BIA)
- Where
- 2 sites in Italy
- Volunteers
- 400 people
- Sponsor
- University of Bari
Celiac Disease
A Double-blind Placebo-controlled Study to Evaluate Larazotide Acetate for the Treatment of Celiac Disease
A randomized, double-blind, placebo-controlled Phase 2B study to evaluate the efficacy and safety of Larazotide Acetate in the treatment of patients with celiac disease who have persistent symptoms despite being on a gluten-free…
- Trial name
- NCT01396213
- Testing
- Larazotide Acetate
- Where
- 62 sites in United States, Canada
- Volunteers
- 342 people
- Sponsor
- 9 Meters Biopharma, Inc.
Diabetes
Quality of Life and Treatment Satisfaction of People With Type 2 Diabetes: A European Survey
The present European survey seeks to assess quality of life and satisfaction with treatment in people with T2DM and to appreciate disease and treatment variables including hypoglycaemia and level of glycaemic control.
- Trial name
- PANORAMA (NCT00916513)
- Where
- 302 sites in France, Germany and 6 more
- Volunteers
- 5,926 people
- Sponsor
- AstraZeneca
Hyperlipidemias, Inflammation
The Effects of Homogenized and Unhomogenized Milk on Postprandial Metabolism in Healthy Overweight Men
The purpose of this study is to compare the effects of homogenized, unhomogenized and skimmed milk on postprandial metabolism in healthy overweight men
- Conditions
- Hyperlipidemias, Inflammation, Atherosclerosis
- Trial name
- NCT01317524
- Testing
- Homogenized milk, Unhomogenized milk, Skimmed Milk
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy, Iron Deficiency
Bioavailability of Iron From Savoury Food Product
The study is designed to assess the bioavailability of iron from 4 different iron fortified savoury food products
- Trial name
- NCT02280915
- Testing
- Savoury food product
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Unilever R&D
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