Clinical trials: Metabolic and Nutritional Disorders
Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities, Overweight (BMI > 25)
AIM-WEIGHT: AI-Guided Microbiome-Targeted Nutritional Intervention for Weight Loss
AIM-WEIGHT is a clinical study evaluating whether a fixed microbiome-targeted nutritional supplement can support weight loss in adults with overweight or obesity who do not have prediabetes or diabetes.
- Trial name
- AIM-WEIGHT (NCT07736547)
- Testing
- AI-Guided Microbiome-Targeted Nutritional Supplement, Lifestyle counselling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Varol TUNALI
Lactose Intolerance
Efficacy, Safety, and Tolerability Study of RP-G28 in Subjects With Lactose Intolerance
RP-G28 is being investigated for treatment of moderate to severe lactose intolerance and its potential to improve the tolerance of lactose (dairy products).
- Trial name
- NCT02673749
- Testing
- RP-G28
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Ritter Pharmaceuticals, Inc.
Post Menopaused Female
Effects of Sensory Motor Training on Balance and Proprioception Among Post-Menopausal Obese Women
Postmenopausal obese women often have difficulties with balance and proprioception. Sensorimotor training is an important part of physical therapy interventions, with emerging evidence that it could be beneficial for…
- Trial name
- NCT04820738
- Testing
- Sensorimotor training exercises, Without Sensorimotor training exercises
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Overweight, Diabetes Type 2
The Efficacy of Bariatric Surgery Compared to Medical Therapy in Controlling Type2 Diabetes Mellitus in Patients With Non Morbid Obesity.
The growing incidence of obesity and type2 DM globally is widely recognized as one of the most challenging contemporary threats to public health.
- Trial name
- NCT02036138
- Testing
- Laparoscopic Sleeve Gastrectomy, Laparoscopic Roux-en-Y Gastric Bypass, Advanced Medical Therapy
- Where
- Israel
- Volunteers
- 76 people
- Sponsor
- Hadassah Medical Organization
Sarcopenia, Sarcopenic Obesity
Prevalence of Sarcopenia and Sarcopenic Obesity in Older Adults
Syndromes such as sarcopenia, sarcopenic obesity and osteosarcopenic obesity are commonly seen in older adults. They result from the impairment of muscle, bone and adipose tissue.
- Conditions
- Sarcopenia, Sarcopenic Obesity, Osteopenia, Osteoporosis
- Trial name
- NCT04122638
- Where
- Turkey (Türkiye)
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- Goztepe Training and Research Hospital
Diabetes Mellitus
Pharmacist-driven CGM Use in the Uninsured Population
This is a pilot study. The purpose is to (1) provide access to continuous glucose monitoring (CGM) to patients (purchased through a grant) and (2) systematically record and analyze the results of the glucose monitoring by the…
- Trial name
- NCT03477838
- Testing
- FreeStyle LibrePro CGM
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Virginia Commonwealth University
Diet, Gluten-Free, Gluten-Sensitive Enteropathy
Non Coeliac Gluten Sensitivity in Children
Irritable Bowel syndrome (IBS) is a very frequent condition in children. Its management is difficult, often resulting in a persistence of chronical abdominal pain.
- Trial name
- NCT02895438
- Testing
- gluten
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Effectiveness and Safety Study of the Abbott Sensor Based Glucose Monitoring Systems
The purpose of the study is to evaluate the safety and effectiveness of the Abbott Sensor Based Glucose Monitoring System Personal (System-P) and Abbott Sensor Based Glucose Monitoring System Professional (System-Pro) when used…
- Trial name
- NCT02283411
- Testing
- Abbott Sensor Based Glucose Monitoring System
- Where
- 6 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Abbott Diabetes Care
Prediabetes, Type 2 Diabetes
Pathobiology and Reversibility of Prediabetes in a Biracial Cohort
The reasons for the epidemics of diabetes and prediabetes, and why individuals from certain populations suffer at higher rates are not well known.
- Conditions
- Prediabetes, Type 2 Diabetes, Obesity
- Trial name
- PROP-ABC (NCT02027571)
- Testing
- Intensive Lifestyle Intervention (ILI)
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- University of Tennessee
Gestational Diabetes Mellitus
Structured Aerobic and Resistance Exercise and Gestational Diabetes
Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance of various degrees first manifested during pregnancy. The primary aim of treating GDM is to optimize glycaemic control and improve pregnancy outcomes.
- Trial name
- NCT02196571
- Testing
- Structured Exercise
- Where
- Croatia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Association for Functional Rehabilitation, Recreation and Applied Kinesiology Impulse
Obesity, Overweight
Partnering With WIC to Prevent Excessive Weight Gain in Pregnancy
The purpose of this study is to determine the effect of an antenatal obesity treatment on gestational weight gain when integrated into Philadelphia WIC.
- Conditions
- Obesity, Overweight, Pregnancy Related
- Trial name
- GWG (NCT03707834)
- Testing
- Antenatal Obesity Treatment (AO)
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Temple University
Type 2 Diabetes
Patients With Type 2 Diabetes Mellitus With Insufficient Glycaemic Control Despite Treatment With Metformin Alone or Metformin in Combination With a Sulfonylurea
The objective of the current study is to investigate the efficacy, safety and tolerability of BI 10773 (10 mg, 25 mg / once daily) compared to placebo given for 24 weeks as add-on therapy to metformin or metformin plus…
- Trial name
- NCT01257334
- Testing
- BI 10773
- Where
- Taiwan
- Volunteers
- 1,390 people
- Sponsor
- Taipei Medical University WanFang Hospital
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital
Diabetes, Diabetes Mellitus
Stanford Clinics Physician Mindset Training
Mindsets play an important role in motivating and shaping health behavior and outcomes. For example, when patients have the mindset that a treatment will work, they are more likely to adhere to treatment medications and the…
- Conditions
- Diabetes, Diabetes Mellitus, Hypertension, Pre Diabetes
- Trial name
- NCT03677609
- Testing
- Mindset & Communication Training
- Where
- United States
- Volunteers
- 78,128 people
- Sponsor
- Kari Alyse Leibowitz
Obesity, Metabolic Disease
Activity, Adiposity, and Appetite in Adolescents 2
Our goal is to examine linkages between physical activity, appetite control, and energy metabolism in adolescents. The investigators will assess metabolic function and appetite control in male and female adolescents stratified by…
- Conditions
- Obesity, Metabolic Disease, Insulin Sensitivity
- Trial name
- AAAA2 (NCT04028921)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Children's Mercy Hospital Kansas City
Insulin Resistance
Novel Therapy for Glucose Intolerance in HIV Disease
This research is to investigate the nutritional supplement chromium picolinate. The investigators are testing to see how effective this supplement is in treating insulin resistance associated with HIV disease.
- Trial name
- NCT02006914
- Testing
- Chromium Picolinate
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Stony Brook University
Healthy Participants
A Trial to Assess the Relative Bioavailability of Different Subcutaneous Formulations of AZD9550 and AZD6234
This study in healthy volunteers aims to compare blood levels and side effects after administration of different formulations of two test medicines, AZD9550 and AZD6234.
- Trial name
- NCT07911514
- Testing
- AZD9550 solution for injection, AZD6234 solution for injection, Formulation 1 solution for injection
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
AL Amyloidosis, Amyloidosis
Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis
The goal of this study is to test the safety of drug, Belantamab Mafodotin, and see what effects (good and bad) it has on people who take it and have amyloidosis, and to determine the most effective dose of the drug.
- Trial name
- NCT05145816
- Testing
- Belantamab mafodotin 2.5 mg/kg (8 weeks), Belantamab mafodotin 1.9 mg/kg (8 weeks), Belantamab mafodotin 1.4 mg/kg (12 weeks)
- Where
- 3 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Texas Southwestern Medical Center
Obesity, Food Insecurity
TARGETing Healthy Weight Loss in the Context of Food Insecurity
This pilot and feasibility study will collect information from food insecure, as well as food secure, women with obesity to detail their desires and needs for healthy weight reduction.
- Conditions
- Obesity, Food Insecurity, Food Security, Body Weight
- Trial name
- TARGET P&F I (NCT05601804)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Rotator Cuff Tear, Rotator Cuff Injury
Analysis for NSAID VS Corticosteroid Shoulder Injection in Diabetic Patients
Sixty patients will be identified in the clinic with rotator cuff tendonitis or a low-grade partial-thickness tear of the rotator cuff that are either insulin-dependent or insulin-independent diabetics.
- Conditions
- Rotator Cuff Tear, Rotator Cuff Injury, Rotator Cuff Tendinitis, Diabetes Mellitus
- Trial name
- NCT03319784
- Testing
- Ketorolac, Triamcinolone Acetonide
- Where
- United States
- Sponsor
- Milton S. Hershey Medical Center
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