Clinical trials: Metabolism and Nutrition Disorder
Diabete Type 2, Obesity
Ph 2a Study of HU6 on Energy Metabolism, Muscle and Liver Substrate Metabolism, and Mitochondrial Function in Subjects Who Are Overweight or Obese With Type 2 Diabetes
This is a randomized, double-blind, placebo-controlled parallel group study of HU6 and placebo in subjects who are overweight or obese with T2D. The study will be conducted in 4 stages.
- Trial name
- NCT06104358
- Testing
- HU6
- Where
- United States
- Sponsor
- Rivus Pharmaceuticals, Inc.
Prader-Willi Syndrome, Sarcopenia
Ultrasound to Assess Sarcopenia in Prader Willi Syndrome
The aim of the study is to examine the clinical applicability of ultrasound as a diagnostic tool for sarcopenia in individuals with PWS by investigating the association between ultrasound-derived measurements, DXA-derived…
- Conditions
- Prader-Willi Syndrome, Sarcopenia, Metabolic Syndrome
- Trial name
- PWS (NCT06448871)
- Testing
- Ultrasound assessment of the right lower extremity muscles, Dual-energy X-ray absorptiometry (DXA) scan
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Severe Acute Malnutrition
Ready to Use Therapeutic Food (RUTF) in Severe Malnourished Children
1. RUTF would be more effective (quicker catch-up growth by promoting more tissue accrue resulting decrease stay in rehabilitation ward) in treating children with SAM during the rehabilitation phase than khichuri /halwa; 2.
- Trial name
- RUTF (NCT01331044)
- Testing
- Plumpy Nut, Khichuri and Halwa
- Where
- Bangladesh
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Obesity
FB4 (Framingham, Boston, Bloomington, Birmingham, and Baylor)
This study will evaluate the effects of dietary carbohydrate and sugar consumption, independent of energy content, on body fatness and metabolism in a rigorous feeding study.
- Trial name
- NCT03394664
- Testing
- Feeding Study
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Surgery, Obese
The Interest of the ANI in the Monitoring of Peroperative Analgesia in Bariatric Surgery
The intraoperative assessment of analgesia remains problematic and no analgesia monitor is used in routine practice.
- Trial name
- ANI (NCT03103698)
- Testing
- To demonstrate the monitoring of perioperative analgesia, Standard preoperative evaluation of analgesia
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Metabolic Dysfunction-Associated Steatotic Liver Disease
The Impact of Nutrition Education and Rice Bran Supplementation on Metabolic Dysfunction-associated Steatotic Liver Disease
This study aims to evaluate the effects of nutrition education with or without rice bran supplementation in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
- Trial name
- NCT07524621
- Testing
- Nutrition Education, Rice Bran
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- Shih Chien University
Non-Alcoholic Fatty Liver Disease
Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD
This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota…
- Trial name
- CARDIO-LIVER (NCT06704321)
- Testing
- TOTUM-448
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Normal Weight, Overweight and Obesity
Effect Cinnamon Spice on Postprandial Glucose and Insulin Responses
The objective of the proposed study is to investigate the effect of cinnamon on the postprandial glycemic response to a high glycemic index meal in normal and overweight/obese prediabetic subjects
- Trial name
- CINNI (NCT04686552)
- Testing
- cinnamon
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Smoking, Overweight
The Effect of a High Protein Diet Versus a Low Fat Diet on Body Weight After Smoking Cessation
The purpose of this study is to determine whether subjects following a high protein diet will gain less in weight after smoking cessation compared to subjects following a low fat diet due to the effects of protein on metabolic…
- Conditions
- Smoking, Overweight, Obesity
- Trial name
- NCT01069458
- Testing
- The high protein diet group and the low fat diet group
- Where
- Norway
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Musculoskeletal Abnormalities, Obesity
GLP-1R Actions on Muscle and the Skeleton
The GRAMS study objectives are to assess the musculoskeletal changes that occur after weight loss using GLP-1 based therapy. A lifestyle intervention with diet and exercise is included to assess any mitigating effects are…
- Conditions
- Musculoskeletal Abnormalities, Obesity, Sarcopenic Obesity, Osteoporosis
- Trial name
- GRAMS (NCT07154719)
- Testing
- Tirzepatide, Lifestyle toolkit
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Pennington Biomedical Research Center
Obesity, Diabetes
Effect of Pomegranate Extract Intake on Body Composition and Blood Pressure.
Pomegranate has gained widespread popularity since the health effects of the whole fruit, as well as its juices and extracts, have been studied in relation to a variety of chronic conditions such as hypertension, diabetes…
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT02017132
- Testing
- Pomegranate extract
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Overweight, Obesity
Experience Success: Virtual Reality Skills Training to Enhance e-Weight Loss
The aim of this Phase II Small Business Technology Transfer grant is to complete development of a virtual reality intervention to augment and improve commercial Internet-delivered behavioral weight loss treatments, and to test it…
- Trial name
- NCT02836132
- Testing
- Weight Watchers Online, Experience Success Virtual Reality Platform
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- The Miriam Hospital
Obesity
Effect of Diltiazem Administration on CP-945,598 Pharmacokinetics
A recently completed clinical drug interaction study of CP-945,598 with ketoconazole, a potent CYP3A inhibitor, showed that coadministration of CP-945,598 with ketoconazole results in an approximately 5-fold increase in…
- Trial name
- NCT00645463
- Testing
- CP-945,598
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Diabetes
Adolescent Fitness Assessment Program
The purpose of this study is to implement a peer modeling intervention to improve self-efficacy and aerobic fitness in obese youth.
- Trial name
- AFAP (NCT01382121)
- Testing
- Peer Modeling, Control
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Western Ontario, Canada
Fetal Macrosomia, Gestational Diabetes
Regulation Of Maternal Fuel Supply And Neonatal Adiposity
The purpose of this study is to determine whether unrecognized maternal hyperglycemia and postprandial lipemia early or late in gestation predicts excess neonatal adiposity.
- Trial name
- NCT00826904
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Overweight and Obesity
Opportunities for Food Reformulation
The objective of this study is to determine the independent and additive effects of food texture and energy density on food and energy intake compared to a control condition.
- Trial name
- OffR (NCT05659771)
- Testing
- Food properties manipulation to alter eating behavior and food and energy intake
- Where
- Netherlands
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Opioid Use, Unspecified, Bariatric Surgery Candidate
Evaluation of the Stress Response in Bariatric Surgery With and Without the Use of Opioids
The goal of this clinical trial is to compare Opioid Free and Opioid Based Anaesthesia in patients undergoing sleeve gastrectomy.
- Trial name
- NCT05752799
- Testing
- Opioid Free Anaesthesia, Opioid based anesthesia
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- G.Gennimatas General Hospital
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Weifang (PKUBC-WF)
The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- NCT06234332
- Testing
- No Interventions
- Where
- China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Peking University
Gestational Diabetes Mellitus, Neurodevelopmental Disorders
n-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum
This study aims to investigate the associations of maternal nutritional status during pregnancy and postpartum periods with postpartum abnormal glucose metabolism in Guangzhou pregnant women.
- Conditions
- Gestational Diabetes Mellitus, Neurodevelopmental Disorders, Postpartum Abnormal Glucose Metabolism, Child Growth and Development
- Trial name
- NCT03023293
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,122 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Diabetes, Obesity
Effects of Antioxidants and B Vitamins Supplements on Inflammation in Obese Diabetic Patients
Substantial evidence shows that diets incorporating antioxidants and B-group vitamins can offer significant protection against infections and cardiovascular disease (CVD) especially in diabetic patients.
- Trial name
- NCT01691365
- Testing
- vitamins
- Volunteers
- 100 people
- Sponsor
- United Arab Emirates University
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