Clinical trials: Metabolites
Virtual Reality, Postpartum Depression (PPD)
Virtual Reality-Assisted Intraoperative Sensory Modulation on Postpartum Depression and the Kynurenine Pathway
The research will be conducted as a prospective, observational, and comparative study with 98 pregnant volunteers aged 18-45 at Düzce University Faculty of Medicine.
- Conditions
- Virtual Reality, Postpartum Depression (PPD), Kynurenine Pathway and Its Metabolites, Pregnancy
- Trial name
- VR effect (NCT07300176)
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Duzce University
Gestational Diabetes Mellitus (GDM), Blood Glucose
Diabetes, Insulin, Gut, Enteric Supplementation Trial
Pregnancy is a critical window for metabolic health, and early changes in blood sugar regulation can increase the risk of gestational diabetes mellitus (GDM), which affects both maternal and infant health.
- Conditions
- Gestational Diabetes Mellitus (GDM), Blood Glucose, Insulin Resistance, Diabetes, Gut Microbiome
- Trial name
- DIGEST (NCT07682077)
- Testing
- Kefir
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Gut Microbiome, Body Composition
Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES) Study
Toddlerhood (ages 2-3) is a critical window when the gut microbiome is still developing and eating habits are being established. Yet, many Canadian toddlers eat diets high in sugar and salt, which may affect long-term health.
- Conditions
- Gut Microbiome, Body Composition, Adherence, Metabolites
- Trial name
- MUNCHIES (NCT07309536)
- Testing
- Mediterranean Diet Nutrition Program, Standard Diet Education Program
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of New Brunswick
Changes in Gut Microbiota, Gut Metabolites, Respiratory Symptoms, and Well-being Index
A Probiotic for Health Outcomes in Short-Term Overseas Travel
With the improvement of living standards, travel has become a common form of leisure. However, travelers often face changes in living environments, dietary habits, and sleep schedules, all of which can impact the gut microbiota…
- Trial name
- NCT07705659
- Testing
- Bifidobacterium longum, Maltodextrin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- DiproBio (Shanghai) Co., Ltd.
Metabolite
Study on the Effect of Atorvastatin Co-administered With Omeprazole on Statin Lactone
This is a 2-arm, prospective, randomized, parallel-group, open-label, longitudinal study that lasts 30 days for each study participant.
- Trial name
- SEACOL (NCT06690164)
- Testing
- Atorvastatin 40mg Tablet, Omeprazole 20mg Capsule
- Where
- Singapore
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Metabolite Concentration, Gut Permeability
Tributyrin: Time Course & Efficacy to Improve Health & Performance
The purpose of this study is to determine if tributyrin supplementation improves metabolite concentrations, overall health biomarkers, and performance in sedentary men and women.
- Conditions
- Metabolite Concentration, Gut Permeability, Inflammation, Sleep
- Trial name
- CoreBiome (NCT06501898)
- Testing
- CoreBiome
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Florida State University
Dermal Exposure, Inhalative Exposure
Application of Plant Protection Products (PPP) in Apple Orchards
The aim of the aPPPle pilot study is to test feasibility and generate first results in preparation for a main study. The aPPPle study will investigate the exposure of operators, workers and residents to plant protection products…
- Conditions
- Dermal Exposure, Inhalative Exposure, Metabolites in Urine, Effekt Biomarker in Blood
- Trial name
- aPPPle (NCT06884189)
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- German Federal Institute for Risk Assessment
Phase I and Phase II Metabolites of Berberine
Metabolic Differences Between Dihydroberberine and Micellar Berberine
Differences in metabolites of dihydroberberine (DHB) and micellar berberine (LipoMicel®, LMB) are investigated through a randomized study involving human volunteers.
- Trial name
- NCT06202157
- Testing
- LMB, DHB
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Factors Group of Nutritional Companies Inc.
Bioavailability, Metabolites
Bioavailability Study of Hemp Phenolics
The aim is to determine the bioavailability of the polyphenol fraction form a commercially available hemp hull fiber at two different amounts in generally healthy adults.
- Conditions
- Bioavailability, Metabolites, Excretion
- Trial name
- NCT06098001
- Testing
- Low dose dietary fiber, High dose dietary fiber
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brightseed
Head and Neck Cancer, Metabolite
A Bidirectional Study in Exploring the Dynamic Changes of Plasma and Urine Metabolites of Head and Neck Cancer
Dynamic changes in the internal environment of the body are important clues for early detection, diagnosis and even cure of head and neck tumors.
- Trial name
- NCT05969262
- Testing
- Proteomics technology and liquid biopsy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Blood Concentration of Tacrolimus Metabolites
Dosage of Tacrolimus Metabolites in Blood and Bile for Prediction of Its Side Effects in Liver Transplant Recipients
The purpose of this study is to evaluate if concentration of tacrolimus metabolites is increased in patients presenting tacrolimus (TAC) side effects.
- Trial name
- STABILE 2 (NCT05277792)
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Rennes University Hospital
Diurnal Variations of Cerebral Metabolite
Diurnal Variations of Brain Metabolite Concentrations in 1H-MRS
Proton Magnetic Resonance Spectroscopy (1H-MRS) is a magnetic resonance imaging (MRI) technique. It allows the quantification of cerebral metabolite concentrations.
- Trial name
- Dyn24 (NCT03497832)
- Testing
- magnetic resonance spectroscopy (MRI)
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Hemorrhagic Stroke, Acute
Predictive Value of Human Microbiome and Serological Markers for Clinical Outcome of Cerebral Hemorrhage
Objective: To explore the predictive value of characteristic disorder of intestinal flora for clinical prognosis in patients with intracerebral hemorrhage.
- Conditions
- Hemorrhagic Stroke, Acute, Outcomes, Metabolites
- Trial name
- NCT05551923
- Testing
- intestinal flora disturbance
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Stress-induced Mood, Kynurenine Pathway and Its Metabolites
Effect of Omega-3 Fatty Acids on Kynurenine Metabolism and Mood
The purpose of the current study is to explore the effect of omega-3 fatty acids supplementation on stress-induced changes to kynurenine metabolism and mood. The objectives of this research project are as follows: 1.
- Trial name
- NCT05520437
- Testing
- Omega-3 fatty acids
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Gut Microbiota, Metabolites
Targeting Gut Microbiota and Metabolites for Very Preterm Infants Through Oropharyngeal Administration of Colostrum
Background: Oropharyngeal administration of colostrum (OAC) has an immune stimulating effect on oropharyngeal-associated lymphoid tissue, and can also promote the maturation of the gastrointestinal tract.
- Trial name
- NCT05481866
- Testing
- Oropharyngeal administration of colostrum, Oropharyngeal administration of sterile water
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Shenzhen People's Hospital
Aging, Metabolites
Metabolomics Profiling Research of Human Cerebrospinal Fluid in Aging Process
Perform quantitative metabolomics on human cerebrospinal fluid (CSF) samples and establish the first human CSF Metabolome Database of aging process in Taiwan.
- Conditions
- Aging, Metabolites, Neurodegenerative Diseases
- Trial name
- NCT04315038
- Testing
- spinal anesthesia
- Where
- Taiwan
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Pharmacokinetics, Metabolites
Levosimendans Pharmacokinetics in Intensive Care Patients. An Observational Study.
Evaluation of the pharmacokinetics of levosimendan and its metabolites in intensive care patients with normal, reduced and dialysis supported renal function.
- Conditions
- Pharmacokinetics, Metabolites, Intensive Care, Renal Failure
- Trial name
- LEFKIP (NCT05076864)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
Metabolites, Gut Microbiota
Interindividual Variation in Excretion of Curcumin
The objective of this project is to elucidate the interindividual variations in excretion of curcumin and its metabolites.
- Trial name
- NCT03746158
- Testing
- curcumin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Probiotics, Oral Health
Double-blind Clinical Trials of Probiotic Products in Oral Health.
In order to evaluate the effects of supplementary probiotics and their metabolites on oral environment and oral microbiota, Taiwan FDA No.
- Conditions
- Probiotics, Oral Health, Probiotic Metabolites
- Trial name
- NCT04289337
- Testing
- Combined probiotics (1), Combined probiotics (2), Combined heat-killed probiotics (1)
- Where
- Taiwan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Glac Biotech Co., Ltd
Cognitive Function, Urinary Metabolites
Effects of Consumption of Nut Components on Cognitive Function, Intestinal Microbial Communities and Markers of Health
Tree nuts (for example brazil nuts, almonds, hazelnuts, walnuts, cashew nuts etc) contain a wide variety of nutrients including fatty acids, polyphenols and micronutrients.
- Conditions
- Cognitive Function, Urinary Metabolites, Intestinal Microbiota
- Trial name
- NCT03500601
- Testing
- Nut components
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Northumbria University