Clinical trials: Metabolome
Diet, Healthy
The Impact of Dietary Protein on the Metabolome
It is known that tumors have an affinity for taking up amino acids from circulation or nearby tissues to use as a fuel source, to enhance their growth.
- Trial name
- NCT05377892
- Testing
- Dietary protein
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Cardiometabolic Health, Healthy Aging
Impacts of Fruit on the Gut Health and Human Health
The objectives of this study are to investigate the effect of fruit consumption on the gut microbiota and their collective fecal and plasma metabolomes, vascular and cardiometabolic functions, cognition, and motor control.
- Conditions
- Cardiometabolic Health, Healthy Aging, Cognition
- Trial name
- NCT05063929
- Testing
- Fruit (2 cup eq), Fruit restriction (1/2 cup eq)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Dietary Rice Bran Supplementation
Pilot Feasibility of Rice Bran Supplementation in Children
The purpose of this study is to assess feasibility of rice bran consumption in weaning children and to identify dietary rice bran mediated changes to the stool microbiome and stool metabolome.
- Trial name
- NCT02557373
- Testing
- Vitamin A, Rice Bran + Vitamin A
- Where
- 2 sites in United States, Mali
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Vulvovaginal Candidiasis, Bacterial Vaginosis
Study of the Microbiota, Metabolome, and Environmental Toxins in Relation to Reproductive Health in Rwandan Women
The overall objective of this clinical pilot study is to determine at a random sampling time, the vaginal microbiome and metabolome of pregnant women, and to see if infection (bacterial vaginosis, vulvovaginal candidiasis…
- Trial name
- RVMM (NCT02150655)
- Testing
- Lactobacillus GR-1 and Lactobacillus RC-14 oral capsules
- Where
- Rwanda
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Diet, Food and Nutrition
Impacts of Durian Consumption on Human Microbiome and Metabolome in Healthy Staff Volunteers
This clinical study investigates the impacts of daily durian consumption on gut microbiota, gut microbial metabolites, and host metabolome in healthy individuals.
- Trial name
- DURIOME (NCT06194084)
- Testing
- Two-sequence of durian pulp doses (100 g and 200 g)
- Where
- Singapore
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Cancer Centre, Singapore
Dietary Exposure
Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study
This proposal aims at identifying new biomarkers of dietary exposure using metabolomic approaches. This project is based on the European Prospective Investigation on Cancer and Nutrition (EPIC) Calibration Study and more…
- Trial name
- NCT03683654
- Testing
- Identify Biomarkers of Dietary Intake in Healthy Subjects
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Sarcopenia
Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults
The investigators recently published significant associations between circulating gut bacteria-related metabolites with lean and skeletal muscle mass and with measures of physical function in older adults, evidence that suggests…
- Trial name
- NCT02811445
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Tufts University
Healthy
American Cranberries to Prevent UTIs in Susceptible Women
The investigator's pre-preliminary study showed that the urine from a portion of study participants had anti-adhesion activity. The investigators propose that UTI susceptible women can be divided into responders and…
- Trial name
- NCT04626362
- Testing
- Cranberry juice
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Florida
Obesity, Overweight
The Effects of Type 1 Diabetes Mellitus and Increased Weight on Gut Microbiome and Urine Metabolome Profiles in Children
This study employs a cross-sectional design to profile the gut microbiome and urine metabolome in overweight/obese children with type 1 diabetes (T1D).
- Conditions
- Obesity, Overweight, Type 1 Diabetes Mellitus
- Trial name
- NCT02938806
- Testing
- No intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Interstitial Lung Disease, Precapillar Pulmonary Hypertension
Exploration of Metabolome in Patients With Interstitial Lung Disease and Pulmonary Hypertension With or Without Specific Pulmonary Hypertension Treatment
Fibrosing interstitial lung diseases (FILDs) encompass a group of rare diseases characterized by progressive pulmonary fibrosis leading to respiratory failure.
- Trial name
- BREATH-TPT (NCT07254338)
- Testing
- Blood sampling for metabolomic profiling, Urine sampling for metabolomic profiling
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Infertility, Assisted Reproductive Technology
Microbiome and Metabolome Profiles in Couples Undergoing IVF and Reproductive Outcomes
This prospective observational cohort study investigates the role of the microbiome and metabolome in couples undergoing in vitro fertilization.
- Conditions
- Infertility, Assisted Reproductive Technology, Pregnancy Complications, Pregnancy Loss, Early
- Trial name
- Mi IVF (NCT07532629)
- Where
- 3 sites in Sweden
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Gut Microbiome
Fiber Blends and Gut Microbiota (FB)
The purpose of this research study is to determine whether consuming snacks containing different blends of dietary fibers alters the type and number of bacteria found in your gut and improves markers of overall health.
- Trial name
- FB (NCT04101344)
- Testing
- Two fiber-blend snack and four fiber-blend snack
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Stress, Healthy
The Efficacy of Pasteurised Akkermansia Muciniphila in Healthy Medical Workers
Gut microbiota alterations secondary to chronic stress might serve as a triggering factor towards manifestation of somatic and mental symptoms. The administration of pasteurised A.
- Conditions
- Stress, Healthy, Dietary Supplement
- Trial name
- MENTAkHEALTH (NCT05738746)
- Testing
- Pasteurized Akkermansia muciniphila
- Where
- 2 sites in Poland
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Hypertension,Essential
Use of Metabolomics to Differentiate the Antihypertensive Effect of Acupuncture From Sham Acupuncture in Hypertensives
To assess the effect of acupuncture versus sham acupuncture on regulating the targeted metabolome of hypertensive patients.
- Trial name
- NCT03492892
- Testing
- Acupuncture
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Healthy
Dose-dependent Identification of Unique Biomarkers
The purpose of the research is to assess the dose-dependent impacts of the consumption of fresh pork on blood-borne metabolites (markers) following the controlled feeding of pork
- Trial name
- NCT05600348
- Testing
- Pork Consumption
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Salt-sensitivity of Blood Pressure
Gut Microbiome, Metabolome, and SSBP
The goal of this interventional study is to learn if elevated Na+ alters the gut microbiota and is associated with altered metabolism, inflammation and salt sensitivity of blood pressure (SSBP).
- Trial name
- Gut-SSBP (NCT07790900)
- Testing
- Dietary sodium
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Weight Management, Obesity
How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types
This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity).
- Conditions
- Weight Management, Obesity, Exercise, Women
- Trial name
- FITGut-W (NCT06691100)
- Testing
- Aerobic Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- George Washington University
Bronchiectasis
Identification of Microbiome and Metabolome of Bronchiectasis in Chinese Population.
This study aims to investigate the characteristics of gut microbiome and metabolome in non-CF bronchiectasis patients, hoping to explore the underlying mechanisms as well as the influence of gut microbiota composition on…
- Trial name
- NCT04490447
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Aspirin, Microbiota
Influence of Aspirin on Human Gut Microbiota Composition and Metabolome
Colorectal cancer (CRC) is the third most common cancer type in males and the second in females, accounting for about 693,900 deaths worldwide per year.
- Trial name
- NCT03450317
- Testing
- Aspirin 80mg
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
RheumatoId Arthritis
Metabolome Analysis in Patients With Rheumatoid Arthritis
The aim of this study is to investigate discriminant metabolites in urine from patients with rheumatoid arthritis (RA) from healthy individuals.
- Trial name
- NCT02960958
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea