Clinical trials: Metabonomics
Hepatic Encephalopathy, Minimal Hepatic Encephalopathy
Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate
Patients with cirrhosis of the liver may suffer from a condition called hepatic encephalopathy which in its mildest form as mental slowing and impaired reaction times in driving and machinery operation.
- Conditions
- Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Cirrhosis
- Trial name
- NCT01847651
- Testing
- Vastus Muscle Biopsy, Cognitive assessment (PHES), Cognitive Assessement (Cogstate)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Imperial College London
Eosinophilic Esophagitis
Metabolomics for Biomarker Discovery in Children With EoE
The investigators are seeking to enroll 8 children ages 2-18 already undergoing upper endoscopy. For the purposes of research, a peripheral blood and clean catch urine specimen will be obtained to measure plasma and urine…
- Trial name
- NCT03107819
- Testing
- Plasma and urine metabolomics
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity
The Effect of a Structured Weight-loss Programme on the Metabolic Profiles of Obese and Overweight Children
Aim: The overall aims of this study to look at what changes are seen overweight and obese (very overweight) children, as they get thinner.
- Trial name
- NCT02608398
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease, Bronchiectasis
Prediction of Pulmonary Rehabilitation Outcomes in Patients With Chronic Respiratory Disease Based on Metabolomics: a Prospective Cohort Study
To comprehensively evaluate the pulmonary rehabilitation (PR) outcomes of patients with chronic respiratory disease (CRD), and to screen biomarkers for predicting different PR outcomes of patients with CRD using metabolomics…
- Trial name
- NCT05681364
- Testing
- metabonomics
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Cancer
Discovery of Biomarkers Related to the Efficacy and Adverse Reactions of Immune Checkpoint Inhibitors Based on Metabolism-genomics
Immune checkpoint inhibitors (ICIs) are an important breakthrough in cancer therapy and have been increasingly used.However, ICIs can cause a unique spectrum of side effects termed immune-related adverse events (irAEs),which can…
- Trial name
- NCT04656119
- Testing
- there is no intervention in our study
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Chao Yang Hospital
Microbiota
Intestinal Microbiota and Thyroid Cancer
Thyroid cancer (TC), the most common malignancy of the endocrine system, is currently the fifth most common malignancy diagnosed in women (1).
- Trial name
- NCT03543891
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Primary Glaucoma
Changes of Trace Elements in Aqueous Humor, Blood and Tears and Analysis of Related Factors
Trace elements are one of the indispensable substances in human body and play an important physiological role. Zinc is a trace element second only to iron in organisms, which is widely distributed in various systems and organs…
- Trial name
- NCT04515030
- Where
- China
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Healthy
Use of Metabonomics and Body Imaging for Metabolic Health Assessment
The aim of this pilot study is to develop at Nestlé Research Center a database of metabolic profiles, body composition, food habits and physical activities on a large cohort of human volunteers.
- Trial name
- NCT02372968
- Testing
- Full body composition and of plasma and urine metabolites
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Colon Cancer, Breast Cancer
SurgicAl Metabolic Phenotyping Longitudinal Evaluation Study
This work will use a new approach to measure how surgery effects human biochemistry and metabolism. It will create a metabolic signature or 'phenotype' for surgical injury that will help clinicians choose the right surgical…
- Conditions
- Colon Cancer, Breast Cancer, Trauma, Inflammatory Bowel Disease
- Trial name
- SaMPLE (NCT01378013)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Severe Major Depression Disorder
Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder
There is heterogeneity in patients with depression. Many scholars propose that individualization of antidepressant achieves better outcomes.
- Trial name
- NMNTDM (NCT02346682)
- Testing
- venlafaxine
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial Tongde Hospital
Narcolepsy
Proteomics and Metabolomics of Body Fluid in Patients With Narcolepsy
Narcolepsy (NRL) is a rare chronic central nervous system dysfunction disease, which is more common in children and adolescents, and less common in adults.
- Trial name
- NCT06279247
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Ulcerative Colitis
Effects of Eicosapentaenoic Acid on Subjects at High Risk for Colorectal Cancer
The aim of this study is to test Eicosapentaenoic acid's effects on markers relevant to colorectal carcinogenesis, RNA and DNA profiles, and the possibility that Eicosapentaenoic Acid treatment might be associated with changes of…
- Trial name
- EPAUC (NCT02069561)
- Testing
- Eicosapentaenoic Acid
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Locally Advanced Rectal Cancer
Tumor Response Prediction in Neoadjuvant Chemoradiation of Locally Advanced Rectal Cancer Using Metabonomics Analysis
This study suggested an effective application of pattern recognition, which figured the possible biological function of potential bio-markers of rectal cancer found in our study based on their chemical structures.
- Trial name
- NCT03149978
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhu Ji
Prediabetic State
Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes (NMR-based Metabonomics)
This study evaluates the efficacy of a 12-month resistance training on metabolic control and reducing the risk of diabetes.
- Trial name
- NCT02561377
- Testing
- resistance training, aerobic training
- Where
- 2 sites in China
- Volunteers
- 276 people
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Coronary Artery Disease
Plaque Stability and Metabolomics in Coronary Heart Disease
At present, the investigators don't know the relationship between plaque stability and the metabonomics changes. In the present study, investigators will evaluate the plaque stability by intravascular unltrasound in stable…
- Trial name
- NCT05270330
- Testing
- This is an observational study, we don't have any interventions.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shaanxi Provincial People's Hospital
Heart Failure, Myocardial Infarction
Clinical and Metabonomics Study on the Treatment of Heart Failure After Myocardial Infarction With Modified Wenxin Decoction
To elucidate the efficacy and safety of weixin decoction in the treatment of heart failure after myocardial infarction.
- Trial name
- NCT04667598
- Testing
- Modified Wenxin Decoction
- Volunteers
- 200 people
- Sponsor
- Jun Li
Cardiovascular Disease
Monocentric Registry to Investigate the Role of Platelet Function, Platelet Genetics, Proteomics and Metabonomics in Heart Disease
Molecular targets on platelets are pivotal for the development of new pharmacological substrates for platelet inhibition and to better understand the impact of platelet-mediated inflammatory processes for the progression of heart…
- Trial name
- TuePIC (NCT01417884)
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Hospital Tuebingen
Neurocognitive Disorders
Study for Perioperative Neurocognitive Disorders After Deep Brain Stimulation Surgery for Parkinson's Disease
Perioperative neurocognitive disorders(PND) is common to see in elderly patients. Although PND increases patient mortality as well as hospitalization time, apparent inflammatory factors, and related mechanisms are still unknown.
- Trial name
- NCT04696978
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- wenbinlu
Clear-cell Metastatic Renal Cell Carcinoma
Evaluation of Predictive Markers for Toxicity and Efficacy in Patients With mccRCC Treated by Anti-VEGF Therapy
The purpose of this study is to assess whether certain metabonomics and/or lipidomics features in correlation with pharmacokinetics before, during and after treatment with sunitinib or pazopanib in first line can predict toxicity…
- Trial name
- METASUN (NCT02570789)
- Testing
- patients with sunitinib or pazopanib
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
IgA Nephropathy
Correlation of Microbiome and Metabonomics With IgA Nephropathy
IgAN is the most prevalent primary glomerulonephritis in China, is characterized by the deposition of IgA1 (particularly, galactose-deficient IgA1) in the glomerular mesangium.
- Trial name
- NCT05190848
- Where
- 5 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital