Clinical trials: Metabonomics
Ulcerative Colitis
Prebiotics in Reducing Inflammation and Clinical Endpoints in Ulcerative Colitis (PRInCE-UC)
The community of microbes living in the gut is called the 'gut microbiome'. Changing this could be an exciting new way of treating people living with ulcerative colitis (UC). UC is a type of inflammatory bowel disease.
- Trial name
- PRInCE-UC (NCT06050811)
- Testing
- 2'-Fucosyllactose
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- Royal Berkshire NHS Foundation Trust
Osteoarthritis, Septic Arthritis
Analysis of Human Knee Joint Fluid Using Metabonomic, Genomic and Tribology Techniques
Making the diagnosis underlying a painful, swollen joint currently involves aspiration followed by numerous microbiological and biochemical laboratory tests.
- Conditions
- Osteoarthritis, Septic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT02565160
- Testing
- Intra-articular aspiration of Joint, Joint irrigation washout, Total Joint Arthroplasty
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Imperial College London
Gastric Cancer
Metabonomics Study of Chronic Gastritis and Gastric Carcinoma
The pathogenetic mechanisms of chronic gastritis and gastric carcinoma are different. Whether metabonomics play a role in the development of chronic gastritis and gastric cancer is still a question.
- Trial name
- NCT04624282
- Testing
- different diseases
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes
Personalised Medicine for Morbid Obesity
The prevalence of morbid obesity (BMI > 40 kg/m2) is increasing rapidly in the UK, but the investigators lack a coherent strategy for detailed assessment and treatment of the individuals affected, who are at high risk of…
- Trial name
- NCT01365416
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Traditional Chinese Medicine, Dyslipidemias
PDR and SKYD of Dyslipidemia's Characteristics From the Oxidative Stress Enhancement Caused by Inhibition of Serine Metabolic Pathway
Clinical epidemiological investigation and modern statistics will be used. Syndrome was quantified by TCM syndrome score scale. Metabonomics, proteomics, transcriptomics, enzyme-linked immunosorbent assay, xanthine oxidation…
- Conditions
- Traditional Chinese Medicine, Dyslipidemias, Syndrome
- Trial name
- PDR SKYD (NCT04909489)
- Testing
- cross-sectional study without intervention
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Alzheimer Disease, Gut Microbiota
A Longitudinal Study to Explore the Impact of Gut Microbiome on Brain Health in Alzheimer's Disease
Gut microbiota dysfunction is associated with Alzheimer's disease (AD). However, the potential modulatory mechanism remains unclear.
- Conditions
- Alzheimer Disease, Gut Microbiota, Metabonomics, Magnetic Resonance Imaging
- Trial name
- NCT06837272
- Testing
- Multi-omics features extraction
- Where
- China
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Jining Medical University
Multiple Myeloma, Bortezomib
Evaluation of Clinical Treatment of Multiple Myeloma Based on Multi-omics
With the emergence of new drugs, the short-term survival rate of multiple myeloma has been significantly increased. However, in clinical treatment, doctors found that different patients may present different clinical efficacy and…
- Trial name
- NCT04678089
- Testing
- Bortezomib
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Prostate Cancer Metastatic
A Multi-omics Study of Metastatic Prostate Cancer (MOSMPCA)
The investigators plan to perform multi-omics technologies, including genomic, transcriptomic, epigenomic and proteomic methods, in patients with metastatic prostate cancer, aiming at uncovering the mechanism of the tumor…
- Trial name
- NCT04660617
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Non-alcoholic Fatty Liver Disease
Urinary Metabonomics of Two Major Patterns of NAFLD
NAFLD(non-alcoholic fatty liver disease, NAFLD) is a common liver disease with a high morbidity which seriously influence people's health.
- Trial name
- NCT02077283
- Where
- China
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- ShuGuang Hospital
Stomach Neoplasms, Gut Microbiota
Gut Microbiota and Metabonomics
To evaluate the correlation between gut microbiota and metabolites in Borrmann type IV gastric cancer; To find the effects of microflora and metabolites on target organs; To detect the mechanism of key flora and metabolite by in…
- Conditions
- Stomach Neoplasms, Gut Microbiota, Metabolomics
- Trial name
- MBS (NCT05205187)
- Testing
- Healthy control specimen collection, Non-Borrmann IV patient specimen collection, Borrmann IV patient specimen collection
- Where
- 6 sites in China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Non-targeted Metabolomics
Mechanism of Umbilical Moxibustion in the Treatment of IBS-b
Evaluate the therapeutic efficacy of umbilical moxibustion therapy for IBS. Compare and analyze the differences in gut microbiota composition and diversity between the umbilical moxibustion group and the control group based on…
- Trial name
- NCT07308262
- Testing
- Umbilical moxibustion
- Volunteers
- 60 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Volatile Organic Compounds, Microbiome
Augmented Response of Volatile Biomarkers in Assessment of Oesophagogastric Cancer (AROMA 1 / BIORESOURCE)
Cancer of the stomach and oesophagus is among the world's top five cancers. Survival rates are very poor as the disease presents late and early symptoms are non-specific.
- Conditions
- Volatile Organic Compounds, Microbiome, Microbioata, Breath Analysis
- Trial name
- NCT05412758
- Testing
- Oral Stimulant Drink
- Where
- United Kingdom
- Volunteers
- 648 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Crohn Disease
Microflora and Metabolomics of Crohn's Disease Patients
The purpose of this study is to explore the microflora characteristics of different ecological loci and multiple metabolic pathways in Crohn's disease patients with different disease course states.
- Trial name
- NCT04965584
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Microbiota
Gut Microbiota and Nonpuerperal Mastitis
Nonpuerperal mastitis (NPM), mainly including Plasma cell mastitis (PCM) and Granulomatous mastitis (GM), which clinical presentation is an accessible and painful breast mass accompanied by skin redness and swelling, nipple…
- Trial name
- NCT05051215
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Hypertension
Metabonomics to Investigate Effects of Healthy Diets on Blood Pressure: the OmniHeart Study
To compare the urinary metabolomes on individuals undergone three different healthy diets--a carbohydrate-rich diet, a protein-rich diet, or a diet rich in unsaturated fat.
- Trial name
- NCT03369535
- Testing
- CARB rich diet, MUFA rich diet, PROT rich diet
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Kent
Diabetic Nephropathy Type 2, Biomarker
Screening and Application Research of Early Diabetic Nephropathy Markers Based on Lipidomics.
Diabetic nephropathy (DN) is one of the major microvascular complications associated with diabetic patients, and also the major global cause of chronic kidney disease and end-stage renal disease (ESRD).
- Trial name
- NCT04931537
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Malignant Biliary Obstruction
Clinical Trial of Bile Etiology ,Proteomics and Metabonomics of Malignant Biliary Obstruction
To investigate bile culture and susceptibility test in patients with malignant biliary obstruction (MBO) or relation between bile, portal vein or vein culture and biliary infection.
- Trial name
- MBO-IR (NCT01073514)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Emergence Agitation, Pain
Risk Factors for Pediatric Emergence Agitation and Analysis of Serum or Urine Metabonomics in Children With Agitation
It is known that some factors are associated with emergence agitation(EA), and investigators are still unable to predict accurately those who undergoing maxillofacial surgery are at great risks.This study intend to identify the…
- Conditions
- Emergence Agitation, Pain, Metabolomics
- Trial name
- NCT04807998
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Fecal Microbiota Transplantation
Metabonomics of COPD and Transplanting of Faecal Bacteria in the Treatment of Its Malnutrition
Oxidative stress can affect the balance of intestinal flora and intestinal structure of patients, resulting in intestinal flora disorder.
- Trial name
- NCT04861649
- Testing
- fecal microbiota transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Asclepius Meditec Inc.
Trauma
Metabonomics Fingerprinting of Multiple Trauma
The aim of this study is to establish plasma metabonomics fingerprinting atlas for severe multiple trauma patient using 1H nuclear magnetic resonance (NMR) based metabonomics methodology and advanced mathematics tools.
- Trial name
- NCT01279239
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sichuan Academy of Medical Sciences