Clinical trials: Metastases to Brain
Brain Metastases
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to small spots in the brain while…
- Trial name
- NCT03550391
- Testing
- Memantine, Hippocampal-avoidant (HA-WBRT) Radiotherapy, Stereotactic Radiosurgery (SRS)
- Where
- 86 sites in United States, Canada
- Volunteers
- 206 people
- Sponsor
- Canadian Cancer Trials Group
Short Time Examination, Brain Metastases
Early [18F]-FDG PET Dynamic Analysis in Brain Metastases After Radiotherapy.
Various treatment options are available for brain metastases, depending on factors such as lesion site or number lesions. Radiotherapy is a commonly used treatment.
- Conditions
- Short Time Examination, Brain Metastases, Radiation Necrosis
- Trial name
- DYNFDGTEP (NCT07632092)
- Testing
- CT scan
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Malignant Melanoma, BRAF V600 Mutation
Binimetinib Encorafenib Pembrolizumab +/- Stereotactic Radiosurgery in BRAFV600 Melanoma With Brain Metastasis
This study evaluates the addition of stereotactic radiosurgery (SRS) to the combination of binimetinib + encorafenib + pembrolizumab in the treatment of BRAFⱽ⁶⁰⁰ mutation-positive melanoma with brain metastases (MBM).
- Conditions
- Malignant Melanoma, BRAF V600 Mutation, Brain Metastases
- Trial name
- BEPCOME-MB (NCT04074096)
- Testing
- Stereotaxic radiosurgery (SRS), Binimetinib Oral Tablet, Encorafenib Oral Capsule
- Where
- 21 sites in France
- Volunteers
- 10 people
- Sponsor
- UNICANCER
Recurrent Brain Metastases
Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study
The purpose of this study is to see if Cs-131 brachytherapy is effective in people with recurrent brain cancer who are scheduled to have brain surgery for removal of their tumor(s).
- Trial name
- NCT04690348
- Testing
- Craniotomy, Cesium-131 brachytherapy
- Where
- 6 sites in United States
- Volunteers
- 103 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Melanoma, Renal Cell Carcinoma
Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma
This is a phase 2, Simon's 2-stage designed study with 2 cohorts of anti-PD-1/PD-L1 experienced patients with untreated brain metastases: 1) melanoma and 2) renal cell carcinoma (RCC).
- Conditions
- Melanoma, Renal Cell Carcinoma, Brain Metastases, PD1/PD-L1 Experienced
- Trial name
- NCT04955743
- Testing
- Pembrolizumab, Lenvatinib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Yale University
Recurrent Brain Metastases, Progressive Brain Metastases
Meclofenamate in Subjects With Recurrent or Progressive Brain Metastasis From Solid Tumor Primary
Cancer that has spread to the brain, or brain metastasis, is difficult to treat. Meclofenamate is a drug which has been shown to reduce brain metastasis growth in the laboratory.
- Trial name
- NCT02429570
- Testing
- Meclofenamate
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Brain Metastases
MeDex: No Perioperative Dexamethasone in Brain Metastases
Perioperative treatment of newly diagnosed cancer patients with brain metastasis without dexamethasone (Dex).
- Trial name
- NCT07044557
- Testing
- Withholding perioperative Dexamethasone
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Louisville
Brain Metastases, Radiotherapy
Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases
Patients suffering from malignancies in advanced stages often develop brain metastases, which limit both the life span and the quality of life.
- Trial name
- Radcav (NCT05871307)
- Testing
- Preoperative Radiotherapy, Intraoperative Radiation, Postoperative Radiotherapy
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Hospital Heidelberg
Brain Metastases, Adult, Brain Metastases From Non-small Cell Lung Cancer (NSCLC)
Avoiding Radiation Therapy Due to Intracranial Response to Chemotherapy, Targeted Therapy and/or Immuno-ONcology Therapy for Brain Metastases: Pilot Pragmatic Trial
This pilot pragmatic trial evaluates the feasibility of avoiding radiation therapy in patients with brain metastases who demonstrate an intracranial response to systemic therapy-including immunotherapy, targeted therapy, and/or…
- Trial name
- ACTION-Brain (NCT06974370)
- Testing
- Active Surveillance
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Vermont Medical Center
Brain Metastases, Brain Metastases, Adult
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
This is a pilot imaging study in participants treated with stereotactic radiosurgery (SRS) to treat brain metastasis. The purpose of this study is to see whether 18F-Fluciclovine positron emission tomography (PET) can be used as…
- Conditions
- Brain Metastases, Brain Metastases, Adult, Brain Cancer
- Trial name
- FACILITATE (NCT06048094)
- Testing
- 18F fluciclovine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Baptist Health South Florida
Melanoma, Brain Metastases
Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases
This is a multicenter, phase II trial of relatlimab (rela), nivolumab (nivo), and ipilimumab (ipi) in patients with asymptomatic and symptomatic melanoma brain metastases.
- Trial name
- NCT06712927
- Testing
- Ipilimumab, Nivolumab + Relatlimab FDC
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Brain Metastases
MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases
The purpose of this study is to test whether an additional magnetic resonance image (MRI) sequence can improve the ability to distinguish radiation damage from tumor recurrence in participants with brain metastasis who have…
- Trial name
- NCT04246879
- Testing
- MRI
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Brain Metastases
Supportive Care With or Without Repeated Whole Brain Radiotherapy in Patients With Recurrent Brain Metastases
Patients with solid cancers may develop cerebral metastases, requiring whole brain radiotherapy (WBRT). Furthermore, in several cases, a secondary course of WBRT might be required due to intracerebral recurrence and limited…
- Trial name
- RECARE (NCT04084431)
- Testing
- Radiation, OSC
- Where
- Germany
- Sponsor
- University Hospital Heidelberg
Non Small Cell Lung Cancer, Brain Metastases, Adult
Nivolumab and Ipilimumab Plus Chemotherapy for Patients With Stage IV Lung Cancer With Brain Metastases
This is an open-label, non-randomised, phase II, multicenter clinical trial. 71 stage IV or recurrent, non-small cell lung cancer patients with synchronous brain metastases will be enrolled in this trial to evaluate the efficacy…
- Conditions
- Non Small Cell Lung Cancer, Brain Metastases, Adult, Lung Cancer
- Trial name
- NIVIPI-Brain (NCT05012254)
- Testing
- Ipilimumab, Nivolumab, Carboplatin
- Where
- 18 sites in Spain
- Volunteers
- 71 people
- Sponsor
- Fundación GECP
Breast Cancer Brain Metastases
Efficacy and Safety of SPH4336 in Combination With Endocrine Therapy in Breast Cancer Patients With Brain Metastases.
This study evaluated the safety and efficacy of SPH4336 in combination with endocrine therapy in breast cancer Patients with brain metastases.
- Trial name
- NCT05872347
- Testing
- SPH4336 Tablets
- Where
- 25 sites in China
- Volunteers
- 52 people
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Brain Metastases
ioMRI in the Surgery of Brain Metastases.
The study aims to improve the surgical treatment of brain metastases through the use of advanced imaging techniques. The investigators are examining how intraoperative MRI (iMRI) can aid surgeons in precisely locating and…
- Trial name
- MET-MRI (NCT07197632)
- Testing
- Surgery with intraoperative MRI
- Where
- Germany
- Volunteers
- 154 people
- Sponsor
- Technical University of Munich
Brain Metastases, Meningiomas
Measuring and Mapping Cognitive Decline After Brain Radiosurgery
Background Stereotactic Radiosurgery (SRS) is a localised radiotherapy treatment for patients with brain metastases or other benign tumours in the brain, like meningiomas.
- Conditions
- Brain Metastases, Meningiomas, Stereotactic Radiosurgery, Cognitive Decline
- Trial name
- CoDeB-Rad (NCT06466720)
- Testing
- Neurocognitive testing, Quality of Life questionnaire, Stereotactic radiosurgery
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Nottingham
Brain Metastases, Adult
Preoperative vs Postoperative Hypofractionated Radiosurgery for Patients With Large Brain Metastases
This is a phase III randomized trial with the aim to compare preoperative HSRS to postoperative HSRS in patients with large at least one BMs from solid tumors suitable for surgical resection.
- Trial name
- SUPPORT (NCT05545007)
- Testing
- Hypofractionated Radiosurgery (HSRS), Brain metastases surgical resection
- Where
- 9 sites in Italy
- Volunteers
- 146 people
- Sponsor
- Istituto Clinico Humanitas
Breast Cancer, Brain Metastases
Brain Radiotherapy Combined With Dalpiciclib and Endocrine Therapy in HR-Positive/HER2-Negative Advanced Breast Cancer With Brain Metastases
This is a prospective, open-label, exploratory clinical trial designed to evaluate the efficacy and safety of brain radiotherapy combined with dalpiciclib and endocrine therapy in HR-positive/HER2-negative advanced breast cancer…
- Conditions
- Breast Cancer, Brain Metastases, HR+/HER2- Breast Cancer
- Trial name
- NCT07539753
- Testing
- Dalpiciclib, Endocrine Therapy of Physician's Choice, Brain Radiotherapy
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Brain Metastases
Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases
This clinical study is a parallel, prospective observational single-centre trial in patients presenting with 5 to 30 brain metastases.
- Trial name
- NCT03775330
- Testing
- Stereotactic Radiosurgery (SRS), Whole brain radiation (WBRT)
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- Sunnybrook Health Sciences Centre