Clinical trials: Metastases to Brain
Metastatic Malignant Neoplasm in the Brain
Single Fraction Stereotactic Radiosurgery or Three to Five Fraction Stereotactic Radiosurgery in Treating Patients With Brain Metastasis That Has Been Removed by Surgery
This phase III trial studies how well single fraction stereotactic radiosurgery works compared with fractionated stereotactic radiosurgery in treating patients with cancer that has spread to the brain from other parts of the body…
- Trial name
- NCT04114981
- Testing
- Single Fraction Stereotactic Radiosurgery, Fractionated Stereotactic Radiosurgery, Quality-of-Life Assessment
- Where
- 232 sites in United States, Canada
- Volunteers
- 242 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Brain Metastases
IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases
This is a Phase I Study evaluating the safety and feasibility of IL-8 receptor-modified patient-derived activated CD70 CAR T cells in adult patients with brain metastases from primary cancer, with either newly diagnosed lesions…
- Trial name
- IMPACT MET (NCT07569263)
- Testing
- Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells, CD70 IHC assay
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Secondary Headache Disorders, Medication-overuse Headache
Medication-overuse Headache: The Effect of a Patient Educational Programme as an add-on to Standard Treatment
The aim of this study is to evaluate the influence of personality profiles in patients with MOH and to evaluate the effect of a custom-made educational programme as an add-on to standard treatment as compared to standard…
- Trial name
- NCT02768233
- Testing
- Educational programme
- Volunteers
- 98 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Brain Metastases
Simvastatin Effect on Radiation Therapy of Brain Metastases
The purpose of the study is to evaluate the effect of simvastatin in combination with radiotherapy on the clinical outcomes of patients with brain metastases.
- Trial name
- NCT02104193
- Testing
- simvastatin in addition to radiation therapy, radiation therapy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Neoplasm Metastases
Prospective Assessment of Quality of Life in Patients Treated by Radiosurgery for Brain Metastases (PRAMECE-1302)
The aim of the study is to assess prospectively the impact of radiosurgery on the quality of life in patients with brain metastases.
- Trial name
- PRAMECE (NCT02565433)
- Testing
- questionnaire administration
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Centre Oscar Lambret
Postdural Puncture Headache
Addition of Pyridostigmine to Conventional Management of Postdural Puncture Headache
Postdural puncture headache (PDPH) is a major complication of neuraxial anesthesia that can occur following spinal anesthesia and with inadvertent Dural puncture during epidural anesthesia.
- Trial name
- NCT05969119
- Testing
- Pyridostigmine
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Small Cell Lung Cancer, Metastatic Carcinoma
Temozolomide in Preventing Brain Metastases in Small Cell Lung Cancer
To investigate the response of temozolomide versus prophylactic cranial radiotherapy in preventing brain metastases in completed or partial remission limited small cell lung cancer patients.
- Trial name
- NCT02605811
- Testing
- temozolomide, prophylaxis cranial radiotherapy
- Where
- China
- Volunteers
- 426 people
- Sponsor
- Guangzhou Medical University
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Methylphenidate to Improve Quality of Life in Patients Undergoing Radiation Therapy for Brain Tumors
RATIONALE: Methylphenidate may decrease side effects of radiation therapy. It is not yet known if methylphenidate is effective in improving quality of life in patients with primary or metastatic brain tumors.
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Depression, Fatigue
- Trial name
- NCT00031798
- Testing
- methylphenidate hydrochloride, quality-of-life assessment, radiation therapy
- Where
- 7 sites in United States
- Sponsor
- Wake Forest University Health Sciences
Brain and Central Nervous System Tumors, Seizure
Levetiracetam in Treating Patients With Seizures Caused by Brain Metastases
RATIONALE: Anticonvulsant drugs, such as levetiracetam, may help control seizures caused by brain metastases. PURPOSE: This clinical trial is studying the side effects and how well levetiracetam works in treating patients with…
- Conditions
- Brain and Central Nervous System Tumors, Seizure, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00415376
- Testing
- levetiracetam, quality-of-life assessment
- Sponsor
- Northwestern University
NSCLC, EGFR Gene Mutation
A Study to Evaluate the Efficacy of Osimertinib With Early Intervention SRS Treatment Compared to the Continuation of Osimertinib Alone, in Patients With EGFR Mutated NSCLC and Asymptomatic Brain Metastases
This study involves patients with EGFR-mutated NSCLC and asymptomatic brain metastases. This is an open-label, randomized study, comparing the continuation of Osimertinib treatment alone to Osimertinib treatment combined with…
- Conditions
- NSCLC, EGFR Gene Mutation, EGF-R Positive Non-Small Cell Lung Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT05033691
- Testing
- Stereotactic surgery
- Where
- Israel
- Volunteers
- 162 people
- Sponsor
- Hadassah Medical Organization
Post-Dural Puncture Headache
Effect of Intrathecal Neostigmine on Post-dural Puncture Headache.
Intravenous neostigmine was recently reported as an effective treatment for PDPH for parturients after intrathecal (IT) block which is postulated to be through its central effects on CSF secretion and cerebral vascular tone…
- Trial name
- NCT05289323
- Testing
- Neostigmine Methylsulfate, Dextrose 5%/Nacl 0.9% Inj
- Where
- Egypt
- Volunteers
- 722 people
- Sponsor
- Alexandria University
Advanced Solid Tumors
A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.
This study will evaluate the safety, tolerability, and preliminary efficacy of EIK1004 (IMP1707) in participants with recurrent advanced/metastatic breast cancer, ovarian cancer, metastatic castrate resistant prostate cancer…
- Trial name
- EIK1004-001 (NCT06907043)
- Testing
- EIK1004-001 (IMP1707-001)
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 130 people
- Sponsor
- Eikon Therapeutics
Traumatic Brain Injury, Cognitive Change
Treating Word Finding Difficulties in Traumatic Brain Injury With HD-tDCS
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will…
- Conditions
- Traumatic Brain Injury, Cognitive Change, Word Finding Difficulty, Acquired Brain Injury
- Trial name
- NCT06840808
- Testing
- Active Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The University of Texas at Dallas
NSCLC, EGFR Activating Mutation
TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases
This study is to evaluate the efficacy and safety of TY-9591 in first-line treatment of patients with EGFR-sensitive mutation-positive non-small cell lung cancer with brain metastases compared to Osimertinib.
- Conditions
- NSCLC, EGFR Activating Mutation, Brain Metastases
- Trial name
- NCT05948813
- Testing
- TY-9591, Osimertinib
- Where
- China
- Volunteers
- 420 people
- Sponsor
- TYK Medicines, Inc
Metastases, Neoplasm, Carcinoma, Non-Small-Cell Lung
Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143)
Brain metastases from solid tumors are diagnosed in more than 300,000 patients annually. Nonsmall cell lung cancer accounts for the majority of CNS mets.
- Conditions
- Metastases, Neoplasm, Carcinoma, Non-Small-Cell Lung, Brain Neoplasms
- Trial name
- NCT00034697
- Testing
- temozolomide
- Volunteers
- 24 people
- Sponsor
- Merck Sharp & Dohme LLC
Stroke, Transient Ischemic Attack
Tailored Intervention to Improve Patient Adherence to Secondary Stroke Prevention Medication
Patient suffering a Transient Ischemic Attack (TIA) or stroke are subsequently at high risk of a new stroke, however, poor adherence to secondary prevention medications occurs frequently within this patient group.
- Trial name
- NCT01684176
- Testing
- Complex tailored intervention, Usual care
- Where
- Denmark
- Volunteers
- 211 people
- Sponsor
- Odense University Hospital
Brain Tumor, Primary, Brain Tumor - Metastatic
Clinical Feasibility of Brain Radiotherapy Using Synthetic CTs in an MRI-only Workflow
The goal of this observational study is to show the feasibility of an MRI-only workflow in brain radiotherapy. The main question it aims to answer is: Is an MRI-only workflow based on deep learning sCTs feasible in clinical…
- Trial name
- NCT06106997
- Testing
- brain radiotherapy
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Non-small Cell Lung Cancer, Brain Cancer
Tarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung Cancer
The goal of this clinical research study is to learn whether Tarceva (erlotinib hydrochloride), when given in addition to whole brain radiation therapy, is better to treat brain metastases in patients with Non-Small Cell Lung…
- Trial name
- NCT00871923
- Testing
- Tarceva (Erlotinib hydrochloride), Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- M.D. Anderson Cancer Center
Childhood B Acute Lymphoblastic Leukemia, Childhood T Acute Lymphoblastic Leukemia
Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia
This clinical trial is looking at brain function in young patients receiving methotrexate for acute lymphoblastic leukemia. Learning about the long-term effects of methotrexate on brain function may help doctors plan cancer…
- Conditions
- Childhood B Acute Lymphoblastic Leukemia, Childhood T Acute Lymphoblastic Leukemia, Cognitive Side Effects of Cancer Therapy, Long-Term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT00437060
- Testing
- Cognitive Assessment, Diffusion Tensor Imaging, Laboratory Biomarker Analysis
- Where
- 112 sites in United States, Australia and 2 more
- Volunteers
- 233 people
- Sponsor
- Children's Oncology Group
Brain Metastases
RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain Metastases
The purpose of this study is to determine whether RTA 744 is effective in the treatment of breast cancer that has metastasized to the brain.
- Trial name
- NCT00538343
- Testing
- berubicin hydrochloride (RTA 744)
- Where
- 7 sites in United States
- Volunteers
- 14 people
- Sponsor
- Biogen