Clinical trials: Metastatic
Neuroendocrine Tumors
177Lu-DOTA-EB-TATE in Patients With Advanced Neuroendocrine Tumors
This is an open-label, non-controlled, non-randomized study to investigate the long-lasting radiolabeled somatostatin analogue based peptide receptor radionuclide therapy and evaluation safety and dosimetry of 177Lu-DOTA-EB-TATE…
- Trial name
- NCT03308682
- Testing
- 177Lu-DOTA-EB-TATE
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Depression Literacy, Depression Stigma
Effects of an Educational Program on Depression Literacy and Stigma Among Secondary School Students in Jazan City
Depression is a serious mental health disease. It is generally characterized by sadness, loss of interest in activities, and decreased energy. Globally, it is estimated that almost 350 million people suffer from depression.
- Trial name
- NCT02663180
- Testing
- Educational program, Video contact
- Where
- Saudi Arabia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Jazan
Head and Neck Cancer
Quality of Life in Head and Neck Patients
Evaluation of health-related quality of life of head and neck cancer patients undergoing immunotherapy
- Trial name
- QLiHN (NCT04853862)
- Testing
- questionnaire
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Age-Related Macular Degeneration
Alpha Lipoic Acid in Geographic Atrophy
Because of its iron-chelating and antioxidant properties, alpha lipoic acid may be a treatment for geographic atrophy (GA) secondary to age-related macular degeneration.
- Trial name
- ALA (NCT02613572)
- Testing
- alpha lipoic acid
- Where
- 5 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Macular Degeneration
Study To Determine Safety/Efficacy of Lucentis For Treatment Of Retinal Angiomatous Proliferation Secondary To Age Related Macular Degeneration
The primary objective of this study is to determine the safety \& efficacy of ranibizumab for the treatment of retinal angiomatous proliferation secondary to age related macular degeneration.
- Trial name
- NCT00395707
- Testing
- Lucentis, Ranibizumab, Ranibizumab (Lucentis)
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The National Retina Institute
HIV
Combination Partner HIV Testing Strategies for HIV-positive and HIV-negative Pregnant Women
The overall objective of this study is to evaluate whether the addition of secondary distribution HIV self-test kits to existing partner notification guidelines increases the proportion of male partners who access facility-based…
- Trial name
- MP3 Pilot (NCT04124536)
- Testing
- HIV self-testing with partner notification.
- Where
- Zambia
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Headache, Migraine
Psychological Assessment and Treatment of Chronic Benign Headache
Subjects with chronic migraine or tension headaches will receive 12 sessions of biofeedback or relaxation training after fulfilling screening, intake interviews, \& psychological testing requirements.
- Conditions
- Headache, Migraine, Tension Headache, Stress Headache
- Trial name
- NCT00018811
- Testing
- Relaxation training & thermal biofeedback, Surface EMG biofeedback
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Influenza
Cellular and Humoral Immune Response to Primary and Secondary Immunization With Subvirion H5N1 Vaccines
The purpose of the study is to evaluate safety and compare how the body reacts to 2 different strengths of the Clade (specific type of H5N1 virus) 2 H5N1 flu vaccine when given as a single vaccination with a high dose (90 mcg) or…
- Trial name
- NCT01086566
- Testing
- Influenza Virus Vaccine, Monovalent A/H5N1 A/Indonesia/05/2005
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cancer Stem Cells, Postoperative Recurrence and Metastasis
Relationship Between Circulating Tumor Stem Cells and the Clinical Pathology
The aim of this study is to establish a platform of detecting and sorting circulating tumor stem cells from peripheral blood in HCC patients; to investigate the relationship between circulating tumor stem cells and their effects…
- Conditions
- Cancer Stem Cells, Postoperative Recurrence and Metastasis, Hepatocellular Carcinoma
- Trial name
- NCT02727673
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Metastatic Triple-negative Breast Cancer
Saci Nivo Rela for TNBC
This is a randomized, open-label, phase Ib study to assess safety and efficacy of sacituzumab govitecan plus nivolumab or sacituzumab govitecan plus a fixed dose combination of nivolumab and relatlimab in patients with any…
- Trial name
- SIMONE (NCT06963905)
- Testing
- Relatlimab FDC + Nivolumab, Sacituzumab Govitecan (SG), Nivolumab
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Vitamin D Deficiency, Secondary Hyperparathyroidism
Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density
Because of its high sun exposure, Israel was traditionally supposed to be protected from vitamin D deficiency, and the country food products hardly contain vitamin D supplements.
- Conditions
- Vitamin D Deficiency, Secondary Hyperparathyroidism, Osteomalacia
- Trial name
- NCT01025128
- Testing
- 25 OH vitamin D
- Where
- Israel
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Cervicogenic Headache, Neck Pain
Multi Cervical Unit Measures of Cervical Isometric Strength and Range of Motion: A Pilot Study
This study is designed to collect normative data on cervical isometric strength and range of motion to supplement an existing normative data base.
- Conditions
- Cervicogenic Headache, Neck Pain, Whiplash, Kyphotic and Reversed Cervical Curves
- Trial name
- NCT00510757
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Logan College of Chiropractic
Metabolic Bone Disease, Transplant-Related Disorder
Assessment of Vertebral Fracture Risk for First Time Liver Transplant Candidates
The researchers are trying to compare the effectiveness of Vertebral Fracture Assessment (VFA) in addition to the current standard of care spine x-ray in evaluation pre-liver transplant patients.
- Conditions
- Metabolic Bone Disease, Transplant-Related Disorder, Secondary Osteoporosis
- Trial name
- VFA (NCT03811873)
- Testing
- Dual x-ray absorptiometry, Vertebral Fracture Assessment
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hyperparathyroidism, Secondary
Impact of Parathyroidectomy on Vascular Calcification and Clinical Outcome in Hemodialysis Patients
The aim of this study is to assess the clinical, laboratory and vascular calcification outcome within 6 months duration in patients undergoing surgical parathyroidectomy (total, subtotal, and total with autotransplantation)
- Trial name
- NCT03724188
- Testing
- surgical parathyroidectomy
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Mansoura General Hospital
Postdural Puncture Headache
Effect of Coffee on Postdural Puncture Headache After Cesarean Section
The purpose of this study is to investigate the effects of postoperative coffee consumption on postdural puncture headache (PDPH) and analgesic use in women undergoing cesarean section with spinal anesthesia.
- Trial name
- NCT07410741
- Testing
- Coffee Consumption
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Physical Activity, Mental Health Issue
1:1 and Group-based Exercise Intervention for Post-secondary Student Mental Health and Well-being
Post-secondary students report alarming rates of feeling overwhelmed, hopeless, anxious, and depressed. To better support student mental health, there is a well-documented need to improve the range and quality of mental health…
- Trial name
- NCT06350877
- Testing
- Physical Activity Intervention
- Where
- Canada
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Breast Carcinoma, Male Breast Carcinoma
Access to Genetic Testing in Underserved Patients With Cancer
This study compares the experiences of people who receive information about genetic testing from a computer-generated character to patients who receive information from a human genetics healthcare provider.
- Conditions
- Breast Carcinoma, Male Breast Carcinoma, Malignant Solid Neoplasm, Metastatic Prostate Carcinoma
- Trial name
- NCT06422455
- Testing
- Best Practice, Educational Intervention, Electronic Health Record Review
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Healthy Adolescents in School-based Population, Emotional Neglect
Recognizing Emotional Neglect and Help-Seeking Intention Among Adolescents in Brussels
The goal of this study is to find out how well adolescents in Dutch-speaking secondary schools in Brussels can recognize emotional neglect, and how this relates to their intention to seek help. The main research questions are: 1.
- Conditions
- Healthy Adolescents in School-based Population, Emotional Neglect, Help-Seeking Behavior
- Trial name
- NCT07365891
- Testing
- Emotional neglect vignettes
- Where
- Belgium
- Volunteers
- 749 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Cancer, Cancer Metastatic
The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors
The purpose of this prospective, interventional, single-arm pilot study is to evaluate whether virtually delivered group-based physical activity is feasible for adolescent and young adult (AYA) cancer survivors.
- Conditions
- Cancer, Cancer Metastatic, Neoplasms, Breast Cancer
- Trial name
- NCT05131815
- Testing
- Virtual group based physical activity (BurnAlong) and Social Media Discussion Board
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Thromboembolism, Unspecified Adult Solid Tumor, Protocol Specific
Detecting Abnormal Blood Clotting in Patients With Metastatic Cancer Undergoing Surgery
RATIONALE: A test that detects abnormal blood clotting in patients with cancer may help doctors plan cancer surgery. PURPOSE: This laboratory study is looking at a new blood test to detect abnormal clotting in patients with…
- Trial name
- NCT00096590
- Testing
- coagulation study, immunoenzyme technique, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)