Clinical trials: Metastatic Liver Disease
Metastatic Colorectal Cancer
PERfusion CT in the FOXFIRE Trial to Study Blood Flow to Liver Metastases
The PERFORM study is a pilot study investigating the feasibility and usefulness of performing a novel CT (Computed Tomography)scanning technique called Perfusion CT(CTP) as an addition to normal CT scanning in patients recruited…
- Trial name
- PERFORM (NCT01410760)
- Testing
- Perfusion CT scan
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Colon Cancer Liver Metastasis, Multiple Pulmonary Nodules
Combined Liver and Right Lung Resection for Colorectal Metastases by Means of J-shaped Thoracophrenolaparotomy
The purpose of this study is to determine whether J-shaped thoracophrenolaparotomy is effective in the surgical treatment of simultaneous liver and right lung metastases from colorectal cancer
- Trial name
- NCT02090816
- Testing
- Surgery of liver and lung
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Milan
Malignant Neoplasm of Large Intestine, Colon Cancer Liver Metastasis
Colectomy in Patients With Asymptomatic and Unresectable Stage IV Colon Cancer
The present study is a multicentric randomized phase III trial designed to assess whether overall survival and quality of life are improved in patients with asymptomatic colon cancer and unresectable SLM treated with resection of…
- Trial name
- CLIMAT (NCT02363049)
- Testing
- Colectomy, Chemotherapy
- Where
- France
- Volunteers
- 278 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Circulating Tumor Cell
Circulating Tumor Cell Capture for Early Diagnosis and Postoperative Tumor Recurrence Monitoring of Liver Cancer
Through the screening of CTCs in patients with suspected liver cancer and liver tumor resection or liver transplantation, the number of CTCs in the blood of liver cancer patients before and after surgery is monitored, and the…
- Trial name
- NCT04688606
- Testing
- Circulating tumor cell capture technology
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Metastatic Malignant Neoplasm in the Liver, Metastatic Uveal Melanoma
Transarterial Chemoembolization for the Treatment of Uveal Melanoma With Liver Metastases
This phase II trial studies the effect of transarterial chemoembolization in treating patients with uveal melanoma that has spread to the liver (liver metastases).
- Conditions
- Metastatic Malignant Neoplasm in the Liver, Metastatic Uveal Melanoma, Stage IV Choroidal and Ciliary Body Melanoma AJCC V8
- Trial name
- NCT04728633
- Testing
- Carmustine, Ethiodized Oil, Transarterial Chemoembolization
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Thomas Jefferson University
Hepatocellular Carcinoma
A Study to Evaluate Lenvatinib Plus Tislelizumab for Locally Advanced Unresectable or Metastatic Hepatocellular Carcinoma With Hepatitis B Virus Infection and Biomarker Analyses
The purpose of this study is to investigate the efficacy and safety of Lenvatinib Plus Tislelizumab for Locally Advanced Unresectable or Metastatic Hepatocellular Carcinoma With Hepatitis B Virus Infection and Biomarker Analyses.
- Trial name
- NCT05897138
- Testing
- Lenvatinib at a dose of 8 mg or 12 mg based on body weight + tislelizumab for one 21-day cycle
- Volunteers
- 30 people
- Sponsor
- Fujian Cancer Hospital
Colorectal Cancer, Liver Metastasis
Sintilimab Combined With Regorafenib and HAIC in Patients With Colorectal Liver Metastasis
To evaluate the safety and efficacy of sintilimab combined with regorafenib and HAIC in patients with colorectal liver metastasis who failed second-line therapy
- Trial name
- NCT05524155
- Testing
- HAIC, Sintilimab, Regorafenib
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Metastatic Carcinoma in the Liver, MLH1 Gene Mutation
Durvalumab and Tremelimumab in Treating Patients With Microsatellite Stable Metastatic Colorectal Cancer to the Liver
This pilot clinical trial studies the side effects and how well durvalumab and tremelimumab work in treating patients with microsatellite stable colorectal cancer that has spread to the liver.
- Conditions
- Metastatic Carcinoma in the Liver, MLH1 Gene Mutation, MSH6 Gene Mutation, PMS2 Gene Mutation
- Trial name
- NCT03005002
- Testing
- Durvalumab, Laboratory Biomarker Analysis, Tremelimumab
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- City of Hope Medical Center
Metastatic Breast Cancer, Liver Metastases
Intra-hepatic Chemotherapy in Patients With Liver Metastases From Breast Cancer and Limited Extrahepatic Disease
This is a phase II trial evaluating intra-hepatic chemotherapy with oxaliplatin every second week in combination with systemic capecitabine and in patients with a HER2-positive tumour in combination with trastuzumab (Herceptin®)…
- Trial name
- NCT01387295
- Testing
- oxaliplatin, capecitabine, trastuzumab
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Dorte Nielsen
Metastatic Colorectal Cancer, Liver Metastases
Optimal Control of Liver Metastases From Colorectal Cancer With Cetuximab and Hepatic Artery Infusion of Chemotherapy
The primary objective of the study is to increase by 15% the complete macroscopic resection rate of predominantly liver metastases from metastatic colorectal cancer through combining systemic cetuximab and hepatic artery infusion…
- Conditions
- Metastatic Colorectal Cancer, Liver Metastases, Hepatic Lesions
- Trial name
- OPTILIV (NCT00852228)
- Testing
- IV cetuximab, HAI chronomodulated chemotherapy, HAI conventional chemotherapy
- Where
- 14 sites in Belgium, France and 2 more
- Volunteers
- 60 people
- Sponsor
- Association pour la Recherche sur le Temps Biologique et la Chronothérapie
Liver Neoplasms, Gastric Cancer (GC)
A Subharmonic-Aided Pressure Estimate Technology for Prediction of Response to Systemic Therapy in Gastric Cancer Liver Metastases
Gastric cancer is a common type of cancer that often spreads to the liver. When cancer spreads to the liver, treatment becomes very difficult. Many patients will undergo chemotherapy to shrink the tumor.
- Conditions
- Liver Neoplasms, Gastric Cancer (GC), Gastric Cancer Metastatic to Liver
- Trial name
- NCT07581730
- Testing
- SHAPE
- Volunteers
- 107 people
- Sponsor
- The First Hospital of Jilin University
Hepatocellular Carcinoma
Trial of TG4023 Combined With Flucytosine in Liver Tumors
This trial is a phase I, open-label, dose-escalating study of the safety or percutaneous intra-tumoral injection of TG4023 (MVA-FCU1) combined with systemic administration of 5-fluorocytosine in patients with primary or secondary…
- Trial name
- NCT00978107
- Testing
- MVA-FCU1, flucytosine
- Where
- 6 sites in France
- Volunteers
- 16 people
- Sponsor
- Transgene
Liver Dysfunction, Liver Metastasis Colon Cancer
Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
The primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy.
- Conditions
- Liver Dysfunction, Liver Metastasis Colon Cancer, Liver Regeneration
- Trial name
- NCT06126419
- Testing
- High-Dose Insulin Therapy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Primary Biliary Cholangitis, Primary Sclerosing Cholangitis
The Effect of Bezafibrate on Cholestatic Itch
Randomized double blind placebo controlled trial to evaluate the antipruritic effect of bezafibrate in patients with moderate to severe cholestatic itch.
- Conditions
- Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Secondary Sclerosing Cholangitis
- Trial name
- FITCH (NCT02701166)
- Testing
- Bezafibrate
- Where
- 9 sites in Netherlands, Spain
- Volunteers
- 84 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pancreatic Cancer With Liver Metastases
Surgical Management of Pancreatic Cancer With Liver Metastasis (Oligometastasis)
Pancreatic cancer is one of the most serious forms of cancer. When it has already spread to the liver, treatment usually consists of chemotherapy rather than surgery.
- Trial name
- POlig (NCT07446946)
- Volunteers
- 68,303 people
- Sponsor
- Richard Hunger
Melanoma, Carcinoma, Hepatocellular
A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors
The Phase 1b part of this study is conducted to assess the safety and tolerability of E7386 in combination with pembrolizumab in participants with previously treated selected solid tumors, and to determine the recommended Phase 2…
- Conditions
- Melanoma, Carcinoma, Hepatocellular, Colorectal Neoplasms
- Trial name
- NCT05091346
- Testing
- E7386, Pembrolizumab, Lenvatinib
- Where
- 32 sites in United States, Japan and 2 more
- Volunteers
- 89 people
- Sponsor
- Eisai Inc.
Hepatocellular Carcinoma
Study of Milciclib in Patients With Unresectable/Metastatic Hepatocellular Carcinoma
The primary aim of this exploratory study is to test the safety and tolerability of milciclib when administered orally at 100 mg in patients with recurrent or metastatic Hepatocellular Carcinoma.
- Trial name
- NCT03109886
- Testing
- Milciclib maleate
- Where
- 14 sites in Greece, Israel and 1 more
- Volunteers
- 31 people
- Sponsor
- Tiziana Life Sciences LTD
Secondary Malignant Neoplasm of Liver, Colorectal Neoplasms
Oslo Randomized Laparoscopic Versus Open Liver Resection for Colorectal Metastases Study
The purpose of the study is to compare outcomes of laparoscopic versus open liver resection for colorectal metastases in a prospective and randomized study.
- Trial name
- Oslo-CoMet (NCT01516710)
- Testing
- Open liver resection, Laparoscopic liver resection
- Where
- Norway
- Volunteers
- 280 people
- Sponsor
- Oslo University Hospital
HCC - Hepatocellular Carcinoma, 125I Seeds Implantation
PD-1 Inhibitor Combined With 125I Seed Implantation for Hepatocellular Carcinoma's Extrahepatic Metastasis: Efficacy and Safety
This study aims to explore the effectiveness and safety of 125I seed implantation in the treatment of hepatocellular carcinoma (HCC) with extrahepatic metastases, and to compare the efficacy differences between PD-1 inhibitor…
- Trial name
- NCT06991907
- Testing
- 125I seed implantation, PD-1 Inhibitors
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Breast Cancer Metastatic to the Liver
Brachytherapy Radiation Directly to the Liver in Breast Cancer Patients With Metastatic to Liver
The purpose of this study to study whether or not the use of direct radiation therapy with Y-90 microspheres (SIR-Spheres) has any effect on treated liver with respect to tumor response in breast cancer patients.
- Trial name
- SIRT (NCT00891800)
- Testing
- Brachytherapy, SIR-Sphere
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- St. Joseph's Hospital, Florida
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