Clinical trials: Metastatic Malignant Neoplasm to Brain
Brain Metastases, Adult
Trial of Preoperative Radiosurgery Versus Postoperative Stereotactic Radiotherapy for Resectable Brain Metastases
The research question is whether a single fraction of preoperative radiosurgery can reduce the incidence of leptomeningeal disease 12 months following resection of a brain metastasis (BM) as compared with 5 fractions of…
- Trial name
- PREOP-2 (NCT05124236)
- Testing
- preoperative radiosurgery, postoperative hypofractionated stereotactic radiotherapy
- Where
- 10 sites in Austria, Germany and 1 more
- Volunteers
- 200 people
- Sponsor
- Susanne Rogers
Non-Small-Cell Lung Cancer (NSCLC), Brain Metastasis
Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer
Background. During the clinical course of patients with locoregionally advanced non-small-cell lung cancer (LA-NSCLC) who have undergone aggressive treatment, brain metastasis (BM) is a frequent seen pattern of disease relapse…
- Trial name
- NCT02448992
- Testing
- hippocampal-sparing WBRT
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Recurrent Glioblastoma Multiforme, Primary Glioblastoma Multiforme
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is being given to patients.
- Conditions
- Recurrent Glioblastoma Multiforme, Primary Glioblastoma Multiforme, Brain Neoplasms, Malignant, Leptomeningeal Disease (LMD)
- Trial name
- NCT03423628
- Testing
- Radiation Therapy, AZD1390
- Where
- 11 sites in United States, Japan and 1 more
- Volunteers
- 159 people
- Sponsor
- AstraZeneca
Brain Metastases, Adult
Neoadjuvant Immunotherapy in Brain Metastases
The purpose of this phase 2 study is to assess the feasibility and efficacy of neoadjuvant immunotherapy in patients with previously untreated, surgically-resectable, solid tumor brain metastases.
- Trial name
- NCT04434560
- Testing
- Nivolumab, Ipilimumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Sarah Sammons, MD
Solid Tumors, Brain Tumors
Satraplatin in Children and Young Adults With Refractory Solid Tumors Including Brain Tumors
Background: Cisplatin and carboplatin are standard cancer treatment drugs used for various childhood cancers, including brain tumors.
- Conditions
- Solid Tumors, Brain Tumors, Brain Metastases
- Trial name
- NCT01259479
- Testing
- Satraplatin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Malignant Neoplasm to Brain
Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases
Brain metastases are the most common brain tumors in adults. It is estimated that around 10-30% of cancer patients would develop brain metastases during the course of their illness.
- Trial name
- NCT04801342
- Testing
- Conformal Whole Brain Radiotherapy with Unilateral Hippocampal Avoidance, Conformal Whole Brain Radiotherapy with Bilateral Hippocampal Avoidance, Memantine Hydrochloride
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- National Taiwan University Hospital
Brain Cancer, Neoplasm Metastasis
Phase I Vorinostat Concurrent With Stereotactic Radiosurgery (SRS) in Brain Metastases From Non-Small Cell Lung Cancer
The purpose of this study is to determine the maximum tolerated dose (MTD) of vorinostat given concurrently with stereotactic radiosurgery (SRS) to treat non-small cell lung cancer (NSCLCA) brain metastases in patient with 1-4…
- Conditions
- Brain Cancer, Neoplasm Metastasis, Lung Cancer, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT00946673
- Testing
- Vorinostat, Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Brain Metastases
Intraoperative Radiotherapy After the Resection of Brain Metastases
INTRAMET examines prospectively the effectiveness of an intraoperative radiotherapy immediate after the surgical resection of brain metastases.
- Trial name
- INTRAMET (NCT03226483)
- Testing
- Intraoperative Radiotherapy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsmedizin Mannheim
Brain and Central Nervous System Tumors, Metastatic Cancer
Carmustine Followed By Surgery in Treating Patients With Recurrent Supratentorial Malignant Glioma or Metastatic Brain Neoplasm
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I/II trial to study the effectiveness of carmustine followed by surgery in treating patients…
- Trial name
- NCT00009854
- Testing
- carmustine in ethanol, conventional surgery
- Where
- 2 sites in United States
- Sponsor
- Direct Therapeutics
Gastric Cancer, Esophageal Cancer
Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers
GENCONCOR-2 is a translational research aimed to compare the molecular profile of primary tumors and their matched brain metastases in gastroesophageal cancers, including cancer of the esophagus, gastroesophageal junction, and…
- Conditions
- Gastric Cancer, Esophageal Cancer, Brain Metastases
- Trial name
- GENCONCOR-2 (NCT07464470)
- Testing
- HER2 Testing, MSI Testing, PD-L1 Testing
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Blokhin's Russian Cancer Research Center
Non-small Cell Lung Cancer
Asymptomatic Brain Metastasis in Non-small Cell Lung Cancer (NSCLC)
The prognosis of NSCLC patients with asymptomatic brain metastasis, who are not treated with SRS or WBRT has not been fully investigated yet.
- Trial name
- NCT01130766
- Testing
- stereotactic radiosurgery (SRS)
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Samsung Medical Center
Brain Metastases
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases
Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to small spots in the brain while…
- Trial name
- NCT03550391
- Testing
- Memantine, Hippocampal-avoidant (HA-WBRT) Radiotherapy, Stereotactic Radiosurgery (SRS)
- Where
- 86 sites in United States, Canada
- Volunteers
- 206 people
- Sponsor
- Canadian Cancer Trials Group
Brain (Nervous System) Cancers, Glioma
Connectome-guided Onco-functional Resection With Tractography-Extended Neuronavigation in Brain Tumor Surgery
Brain tumor surgery in so-called "eloquent" brain areas aims to remove as much tumor as possible while preserving neurological functions.
- Conditions
- Brain (Nervous System) Cancers, Glioma, Brain Metastasases, Brain Connectivity
- Trial name
- CORTEx (NCT07717827)
- Testing
- Connectome-guided network-based neuronavigation, Advanced diffusion MRI tractography and connectome pipeline
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- ARNAS Civico Di Cristina Benfratelli Hospital
Breast Cancer Metastatic, Brain Metastasases
Study Investigating the Role of Routine Screening and Molecular Characterisation of Brain Metastasis in the Management of High-risk Metastatic Breast Cancer
The purpose of this study is to improve outcome of breast cancer patients who develop brain metastases. This will investigate the benefits of early detection of brain metastases using brain imaging.
- Trial name
- STORM (NCT06728150)
- Testing
- computerized tomography
- Where
- Australia
- Volunteers
- 45 people
- Sponsor
- Monash University
Malignant Brain Tumors
Expert Consensus and Artificial Intelligence in Medical Decision Making in Patients with Malignant Brain Tumors
Nearly 23,000 adults are diagnosed with primary central nervous system (CNS) malignancy yearly. An additional 200,000 adults are diagnosed with brain metastasis. There are significant variations in CNS tumor treatment.
- Trial name
- EC-AIM Brain (NCT06649591)
- Testing
- Survey
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Tufts Medical Center
Brain Metastasases
Magnetic Resonance-Guided Laser Interstitial Thermal Therapy for Brain Metastases Trial
In accordance with the requirements of the "Good Clinical Practice for Medical Devices", this clinical trial is conducted to further evaluate the safety and efficacy of the magnetic resonance-guided laser ablation treatment…
- Trial name
- NCT07132203
- Testing
- Laser interstitial thermal therapy
- Where
- 6 sites in China
- Volunteers
- 98 people
- Sponsor
- Beijing Tiantan Hospital
Neoplasm Metastasis
Whole Brain Radiation Therapy With Boost to Metastatic Tumor Volume Using RapidArc
Brain metastases are the most common adult intracranial tumor, occurring in approximately 10% to 30% of adult cancer patients, and represent an important cause of morbidity and mortality.
- Trial name
- NCT01218542
- Testing
- Volumetric modulated arc therapy
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Metastatic Breast Cancer
Eribulin in Brain Metastases From HER2-negative Breast Cancer
To evaluate the efficacy of eribulin for treatment of HER2-negative breast cancer brain metastases (BCBM)
- Trial name
- ERIBRAIN (NCT03637868)
- Testing
- Eribulin
- Where
- 7 sites in France
- Sponsor
- Institut Paoli-Calmettes
Nonsmall Cell Lung Cancer
Chemotherapy With or Without Radiosurgery for Asymptomatic Oligo Brain Metastasis
The need of radiosurgery is controversial for asymptomatic oligo brain metastasis for non small cell lung cancer (NSCLC). Therefore, the investigators do a randomized study comparing overall survival between two groups with or…
- Trial name
- NCT01301560
- Testing
- Radiosurgery, Observation
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Samsung Medical Center
Lung Cancer
Prophylactic Cranial Irradiation in Patients With Lung Adenocarcinoma With High Risk of Brain Metastasis
Lung cancer is the first cause of death among cancer patients. Non Small Cell lung cancer (NSCLS) represents about 80-85% of the cases. Of this, about 80% presents with locally advanced or metastatic disease.
- Trial name
- PCI (NCT01603849)
- Testing
- Prophylactic Cranial Irradiation
- Where
- Mexico
- Volunteers
- 84 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
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