Clinical trials: Metastatic Malignant Neoplasm to Brain
Malignant Neoplasm Brain
Pre-operative Stereotactic Radiosurgery Followed by Resection for Brain Metastases
The primary goal of this research study is to determine the efficacy of giving pre-operative radiosurgery to patients pending resection of a brain metastasis.
- Trial name
- NCT02514915
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Christopher Wilke
Metastatic Breast Cancer
Study of SHR-A1811 in HER2-expression Advanced Breast Cancer With Brain Metastases
This study aimed to evaluate the use of SHR-A1811 in HER2-expression Advanced Breast Cancer patients with brain metastases.
- Trial name
- NCT05769010
- Testing
- SHR-A1811, Pyrotinib, Bevacizumab
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Henan Cancer Hospital
Non-small Cell Lung Cancer, Brain Cancer
Tarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung Cancer
The goal of this clinical research study is to learn whether Tarceva (erlotinib hydrochloride), when given in addition to whole brain radiation therapy, is better to treat brain metastases in patients with Non-Small Cell Lung…
- Trial name
- NCT00871923
- Testing
- Tarceva (Erlotinib hydrochloride), Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- M.D. Anderson Cancer Center
Brain Metastases
EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active
To learn if consolidative stereotactic radiosurgery (cSRS) can help to control central nervous system (CNS) disease in patients who have brain metastases and have a partial response or stable brain metastases after systemic…
- Trial name
- NCT06649058
- Testing
- Systemic Therapy, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Brain Metastasis
PCI in Advanced Triple Negative Breast Cancer Patients Who Response to 1st Line Chemotherapy
The purpose of this study is to compare whether prophylactic cranial irradiation in patients with advanced triple negative breast cancer who had a response to first line chemotherapy could prolong brain-metastasis free survival.
- Trial name
- NCT02448576
- Testing
- prophylactic cranial irradiation
- Where
- China
- Volunteers
- 326 people
- Sponsor
- wang shusen
Recurrent Melanoma, Stage IV Melanoma
Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases
This phase I trial studies the best dose of vemurafenib when combined with whole brain radiation therapy (WBRT) or stereotactic radiosurgery (SRS) in patients with v-raf murine sarcoma viral oncogene homolog B (BRAF)…
- Conditions
- Recurrent Melanoma, Stage IV Melanoma, Tumors Metastatic to Brain
- Trial name
- NCT02145910
- Testing
- Vemurafenib, Whole-brain radiation therapy (WBRT), Radiosurgery (SRS)
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Metastases, Neoplasm, Carcinoma, Non-Small-Cell Lung
Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung Cancer (Study P02143)
Brain metastases from solid tumors are diagnosed in more than 300,000 patients annually. Nonsmall cell lung cancer accounts for the majority of CNS mets.
- Conditions
- Metastases, Neoplasm, Carcinoma, Non-Small-Cell Lung, Brain Neoplasms
- Trial name
- NCT00034697
- Testing
- temozolomide
- Volunteers
- 24 people
- Sponsor
- Merck Sharp & Dohme LLC
Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8
Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases
This phase I/II trial studies the best dose and effect of pimasertib in combination with bintrafusp alfa in treating patients with cancer that has spread to the brain (brain metastases).
- Conditions
- Anatomic Stage IV Breast Cancer AJCC v8, Clinical Stage IV Cutaneous Melanoma AJCC v8, Hematopoietic and Lymphoid Cell Neoplasm, Hormone Receptor Positive Breast Adenocarcinoma
- Trial name
- NCT04789668
- Testing
- Bintrafusp Alfa, Pimasertib, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Adult Anaplastic (Malignant) Meningioma, Adult Anaplastic Astrocytoma
Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases
This pilot clinical trial compares gadobutrol with standard of care contrast agents, gadopentetate dimeglumine or gadobenate dimeglumine, before dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) in diagnosing…
- Conditions
- Adult Anaplastic (Malignant) Meningioma, Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma
- Trial name
- NCT02967380
- Testing
- Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Gadobenate Dimeglumine, Gadobutrol
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Breast Cancer, Metastatic Breast Cancer
T-DXd Therapy for HER2-low Breast Cancer Patients With Brain Metastases
TUXEDO-4 is an international, multicentric, single arm, phase II study aiming to gather additional solid evidence of Trastuzumab-Deruxtecan (T-DXd) activity in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-low…
- Trial name
- TUXEDO-4 (NCT06048718)
- Testing
- Trastuzumab-Deruxtecan (T-DXd)
- Where
- 13 sites in Austria, Spain
- Volunteers
- 28 people
- Sponsor
- MedSIR
NSCLC Patients With EGFR Activating Mutation, Adenoid Cystic Carcinoma Metastatic
First in Human Multicenter Open Name Dose-increase, Consolidation Method to Study Safety Drug-level in Blood & Drug Metabolism Clinical Activity of Oral JBI-778 in Lung Cancer Patients With, Without Brain Metastasis IDH Mutated WHO Grade 3,4 Recurrent Glioma, Salivary Glands Tumor
This is a phase 1, multicentre, first-in-human, open-label, dose-escalation/consolidation study to investigate the safety, pharmacokinetics, pharmacodynamics, and clinical activity of orally administered JBI-778 in EGFR mutated…
- Conditions
- NSCLC Patients With EGFR Activating Mutation, Adenoid Cystic Carcinoma Metastatic, Adenoid Cystic Carcinoma of the Head and Neck
- Trial name
- NCT07755397
- Testing
- JBI-778
- Where
- 6 sites in India
- Volunteers
- 30 people
- Sponsor
- Jubilant Therapeutics India Limited
Nonsmall Cell Lung Cancer
Chemotherapy With or Without Radiosurgery for Asymptomatic Oligo Brain Metastasis
The need of radiosurgery is controversial for asymptomatic oligo brain metastasis for non small cell lung cancer (NSCLC). Therefore, the investigators do a randomized study comparing overall survival between two groups with or…
- Trial name
- NCT01301560
- Testing
- Radiosurgery, Observation
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Samsung Medical Center
Glioblastoma, Brain Metastases
Preoperative Ceritinib (LDK378) in Glioblastoma Multiforme and CNS Metastasis
This is two parallel studies to examine pharmacokinetic (PK), pharmacodynamic (PD), and pharmacogenetic (PG) endpoints following short-interval therapy (10-14) daily doses without dose reduction and interruption) with the ALK…
- Trial name
- NCT02605746
- Testing
- ceritinib 750mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Brain Metastases
Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis
This multicentre proof-of-concept study, involving 4 centers, aims to establish the value of fractionated neoadjuvant stereotactic radiotherapy (NaSRT) as a new treatment paradigm for brain metastases (BM) in the frame of the…
- Trial name
- NeoSTROBE (NCT06933199)
- Testing
- Neoadjuvant Stereotactic Radiotherapy (NaSRT), Postoperative Stereotactic Radiotherapy (SRT)
- Where
- 4 sites in Czechia
- Volunteers
- 260 people
- Sponsor
- University Hospital Ostrava
Metastatic Malignant Neoplasm in the Brain
Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases
This phase III trial compares the usual treatment of surgery after stereotactic radiosurgery (SRS) to receiving SRS before surgery in treating patients with cancer that has spread to the brain (brain metastases).
- Trial name
- NCT05438212
- Testing
- Brain Surgery, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 216 sites in United States, Canada and 1 more
- Volunteers
- 237 people
- Sponsor
- NRG Oncology
Brain Oligometastatic, Non-small Cell Lung Cancer
Brain Oligometastasis in NSCLC
75-80% of NSCLC are diagnosed at the metastatic stage. Among the most frequent sites are brain metastases. The management of patients with exclusive limited brain involvement is not standardized.
- Trial name
- OligoLung (NCT07389642)
- Testing
- Standard treatments / multiple strategies
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Bordeaux
Lung Cancer and Breast Cancer Patients With Brain Metastases
A Phase II Multi-center Pilot Study of Concurrent Temozolomide and Whole Brain Irradiation in Lung Cancer and Breast Cancer Patients With Brain Metastases
Brain metastasis (BM) is among the most feared complications in cancer because even small tumors may cause incapacitating neurologic symptoms.
- Trial name
- NCT02133677
- Testing
- temozolomide 100mg
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Far Eastern Memorial Hospital
Tumors Metastatic to Brain
Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study
This Phase I/II trial studies the ability to stop brain metastases from coming back after treatment with radiosurgery followed by surgical resection.
- Trial name
- NCT01891318
- Testing
- radiosurgery, therapeutic conventional surgery, quality-of-life assessment
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Case Comprehensive Cancer Center
Rectal Neoplasms, Rectum Cancer
SGM-101 in Colorectal Brain Metastases.
This study assesses the feasibility of SGM-101, a fluorochrome-labeled anti-carcinoembryonic antigen monoclonal antibody, for intraoperative near-infrared fluorescence imaging of colorectal brain metastases by injecting SGM-101…
- Conditions
- Rectal Neoplasms, Rectum Cancer, Colorectal Neoplasms, Brain Metastases
- Trial name
- SGM-CBM (NCT04755920)
- Testing
- SGM-101
- Where
- 2 sites in Netherlands
- Volunteers
- 10 people
- Sponsor
- Leiden University Medical Center
Non-small Cell Lung Cancer (NSCLC)
Investigate the Maximum Tolerated Dose of Vandetanib and Concurrent Whole Brain Radiotherapy (WBRT) in Patients With Non-small Cell Lung Cancer (NSCLC) and Brain Metastases
A clinical study to investigate the maximum tolerated dose of Vandetanib and concurrent WBRT in patients with NSCLC and brain metastases. All patients will receive WBRT, 10 fractions of 3 Gy.
- Trial name
- NCT00807170
- Testing
- ZD6474 (Vandetanib), Whole Brain Radiotherapy (WBRT), ZD6474
- Where
- 3 sites in Netherlands
- Volunteers
- 5 people
- Sponsor
- Sanofi
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