Clinical trials: Methadone
Opioid Dependence, Obesity
The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence
Methadone maintenance therapy (MMT) has shown clear efficacy for relieving opioid withdrawal symptoms and reducing the morbidity and mortality of opioid dependence.
- Trial name
- NCT03575273
- Testing
- Sniffin' Sticks Odor Identification and Hedonic Scale, Sucrose Taste Preference Assessment, Food Preferences Task
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Healthy Participants
A Study to Investigate the Potential Interaction Between Telaprevir and Methadone, at Steady-State
The purpose of this study is to evaluate the effect of steady-state (constant concentration of medication in the blood) telaprevir 750 mg every 8 hours on the steady-state pharmacokinetics (how the drug concentrations change over…
- Trial name
- NCT00933283
- Testing
- Telaprevir, Methadone
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Tibotec BVBA
Healthy
A Clinical Trial in Healthy Participants to Study the Effect of a Single Dose of MK-8527 on Levels of Methadone (MK-8527-020)
The goal of this study is to learn about the effect of a study medicine called MK-8527 when taken with methadone. The study will also measure what happens to the methadone in a healthy person's body over time after MK-8527 is…
- Trial name
- NCT07528508
- Testing
- MK-8527, Methadone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cesarean Delivery
Intravenous Methadone Versus Intrathecal Morphine for Analgesia Following Cesarean Delivery
The purpose of this study is to determine if there is a difference in opioid requirements at 0-48 hours after scheduled cesarean delivery in patients receiving 150 mcg intrathecal morphine compared to 0.2 mg/kg (maximum 20 mg)…
- Trial name
- NCT06826742
- Testing
- Intravenous line (IV) Methadone, Intrathecal Morphine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Opioid-Related Disorders
Effects of Buprenorphine/Naloxone in Treating Opioid Dependent Individuals Who Are Maintained on Methadone
Buprenorphine is a drug that may be helpful in treating opioid dependent individuals who were previously maintained on methadone.
- Trial name
- NCT00000243
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid-Related Disorders, Pregnancy
Opioid Dependence Treatment Therapies in Pregnancy
The incidence of opioid dependence in pregnancy increased over the last decade from 1.2 to 5.8 per 1,000 hospital births per year.1 While methadone is the current, standard treatment for opioid dependent (OD) pregnant women…
- Trial name
- NCT03098407
- Testing
- Buprenorphine, Methadone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
HIV Risk Behaviors, Heroin Injection
Efficacy of Drug and Risk Counseling Among Methadone Patients in Jakarta, Indonesia
According to UNAIDS, Indonesia is experiencing one of the most rapidly expanding HIV/AIDS epidemics in Asia. The epidemic in Indonesia has been fueled by injection drug use among heroin users and the national response includes…
- Conditions
- HIV Risk Behaviors, Heroin Injection, Retention in Methadone Treatment
- Trial name
- JAKPRO (NCT01360463)
- Testing
- Behavioral Drug and Risk Counseling (BDRC), methadone maintenance treatment
- Where
- Indonesia
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Opioid Use Disorder, Depressive Disorder
Ketamine for OUD and Comorbid Depression (OUDCD)
Methadone is a first-line, evidence-based treatment for opioid use disorder (OUD). Unfortunately, retention and adherence in methadone treatment is a major challenge.
- Trial name
- NCT05051449
- Testing
- Ketamine Hydrochloride
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Healthy Volunteer
A Study on the Interaction Between Danoprevir/Ritonavir and Methadone
This multicenter, open-label study will assess the effect of multiple doses of danoprevir/ritonavir on steady-state pharmacokinetics of methadone.
- Trial name
- NCT01389544
- Testing
- danoprevir, methadone, ritonavir
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Opioid-Related Disorders, HIV
Neurocognitive Effects of Opiate Agonist Treatment
The purpose of this study is to (1) compare the effects of buprenorphine and methadone, two types of opioid addiction treatment, on the ability to think and reason among people addicted to opiates, and who are either HIV negative…
- Conditions
- Opioid-Related Disorders, HIV, HIV Infections
- Trial name
- NEO (NCT01733693)
- Testing
- Buprenorphine, Methadone
- Where
- 2 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Chronic Hepatitis C
Drug Interaction Study Of Filibuvir With Methadone Among Subjects On Chronic Methadone Maintenance
Filibuvir, a CYP3A4 inhibitor is being developed for the treatment of chronic Hepatitis C infection. Given the likelihood of co administration of filibuvir and methadone, this study will evaluate the effect of filibuvir on the…
- Trial name
- NCT01210404
- Testing
- filibuvir
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Methamphetamine Use Disorder, Drug Interaction
Mirtazapine and Methamphetamine Drug-drug Interaction Study
This is a drug-drug interaction (DDI) study of mirtazapine for methamphetamine (MA) use disorder (MUD) to ensure the safety of this medication in the presence of a relevant dose of MA for people actively-using MA.
- Conditions
- Methamphetamine Use Disorder, Drug Interaction, Cardiovascular Abnormalities
- Trial name
- NCT04614584
- Testing
- Mirtazapine, Methamphetamine
- Where
- 3 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
Pharmacokinetics of Isavuconazole, Pharmacokinetics of Methadone
Drug Interaction Study of Isavuconazole and Methadone
The primary purpose of this study is to assess the effect of multiple doses of isavuconazole on the pharmacokinetics (PK) of methadone after single dose administration.
- Conditions
- Pharmacokinetics of Isavuconazole, Pharmacokinetics of Methadone, Healthy Volunteers
- Trial name
- NCT01582425
- Testing
- Isavuconazole, Methadone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Degenerative Disc Disease, Spondylolisthesis, Lumbar Region
Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions
Spinal operations including lumbar fusions for degenerative disorders are becoming more prevalent as the population ages. Inadequate or excessive postoperative analgesia can result in medical comorbidities and prolonged hospital…
- Trial name
- NCT04112550
- Testing
- Methadone Hydrochloride, Oxycodone-Acetaminophen
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Thoracolumbar Scoliosis
A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery
Scoliosis is a disease that involves lateral and/or rotational deformity of the spine and can affect up to 4% of the population.
- Trial name
- NCT02206685
- Testing
- Methadone, Normal Saline
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Neuropathic Pain
Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REL-1017 (d-Methadone)
This study evaluated the safety, tolerance, and pharmacokinetics (PK) of d-methadone in a limited dose range, in multiple administrations in humans.
- Trial name
- NCT03638869
- Testing
- REL-1017
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Relmada Therapeutics, Inc.
Postoperative Pain
Intraoperative Methadone for Postoperative Pain in Patients Undergoing Tonsillectomy
A randomized controlled trial evaluating the efficacy and safety of single-shot intraoperative methadone for postoperative pain in patients undergoing tonsillectomy. Fentanyl is used as an active comparator
- Trial name
- METATONS (NCT05445856)
- Testing
- Methadone, Fentanyl
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
Study of Tipranavir and Ritonavir on the Pharmacokinetic Characteristics of Methadone Administered in Healthy Volunteers
The primary objective of this study is to characterise the effects of tipranavir 500 mg and ritonavir 200 mg (TPV/r; given twice daily) at steady-state on the pharmacokinetics of methadone administered as a single dose in healthy…
- Trial name
- NCT02245451
- Testing
- Tipranavir, Ritonavir, Methadone
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Opioid Use Disorder
Investigation of the Pharmacokinetic Profile of CBD
The goal of the current study is to evaluate the bioavailability of CBD in normal healthy Individuals. This is an open cross-overdesign study in healthy individuals to assess the safety and pharmacokinetic (PK) effects of…
- Trial name
- NCT05269706
- Testing
- Cannabidiol 200mg, Epidiolex, Cannabidiol 400mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yasmin Hurd
Sleep Disorder (Disorder)
Efficacy of Electro-Acupuncture Therapy for Patients With Methadone Maintenance Treatment
The population of drug abuse(heroin) had reached about 200,000 in Taiwan, and the age distribution is mainly in young adults. The social, medical and economic problems of drug addiction are profound and include lost productivity…
- Trial name
- NCT03881618
- Testing
- electroacupuncture+auricular pressure,
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei City Hospital