Clinical trials: Methadone-maintenance Subjects
Methadone-maintenance Subjects
Study Evaluating Oral MOA-728 in Subjects on Methadone Therapy
To evaluate the effects of single oral doses of MOA-728 compared to a positive control in subjects on methadone therapy.
- Trial name
- NCT00505583
- Testing
- MOA-728
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Adult
Dose Ranging Study in Healthy Methadone Maintenance Subjects
To assess the effect of a single oral dose of MOA-728, an investigational drug, on the oral-cecal transit time in subjects who are taking methadone.
- Trial name
- NCT00387491
- Testing
- MOA-728
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Hepatitis C
A Study to Investigate the Potential Pharmacokinetic Interaction Between TMC435 and Methadone
The purpose of this study is to evaluate the effect of steady-state (constant concentration of medication in the blood) TMC435 (150 mg, once a day) on the steady state pharmacokinetics (what the body does to the medication) of R…
- Trial name
- NCT00915564
- Testing
- TMC435, Methadone
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Constipation
Double-Blind, Double-Dummy, 2-Period Crossover of a 20-Minute Versus a 4-hour IV of MOA-728 in Stable Methadone Subjects
MOA-728, an investigational drug, is currently being studied for the relief of constipation associated with postoperative ileus and treatment of opioid induced constipation in patients receiving palliative care.
- Trial name
- NCT00444158
- Testing
- MOA-728
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
HIV
TMC278-TiDP6-C121: Drug-drug Interaction Trial to Investigate the Potential Interaction Between TMC278 25 mg Daily and Methadone, at Steady State.
The purpose of this Phase I, open-label, single-sequence drug-drug interaction trial in patients on stable methadone maintenance therapy is to investigate the potential interaction between TMC278 25 mg daily and methadone, at…
- Trial name
- NCT00744770
- Testing
- TMC278
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Tibotec Pharmaceuticals, Ireland
Healthy Participants
A Study to Investigate the Potential Interaction Between Telaprevir and Methadone, at Steady-State
The purpose of this study is to evaluate the effect of steady-state (constant concentration of medication in the blood) telaprevir 750 mg every 8 hours on the steady-state pharmacokinetics (how the drug concentrations change over…
- Trial name
- NCT00933283
- Testing
- Telaprevir, Methadone
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Tibotec BVBA
Healthy Volunteer
A Study on the Interaction Between Danoprevir/Ritonavir and Methadone
This multicenter, open-label study will assess the effect of multiple doses of danoprevir/ritonavir on steady-state pharmacokinetics of methadone.
- Trial name
- NCT01389544
- Testing
- danoprevir, methadone, ritonavir
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Chronic Hepatitis C
Drug Interaction Study Of Filibuvir With Methadone Among Subjects On Chronic Methadone Maintenance
Filibuvir, a CYP3A4 inhibitor is being developed for the treatment of chronic Hepatitis C infection. Given the likelihood of co administration of filibuvir and methadone, this study will evaluate the effect of filibuvir on the…
- Trial name
- NCT01210404
- Testing
- filibuvir
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Substance Use Disorder
OPAL: "Opiates and PhArmacoLogy"
The aim of this study is to determine the current prevalence of co-addictions, including problem/pathological gambling, in patients receiving Opiate Substitution Treatment (OST), and to then compare patients receiving OST with or…
- Trial name
- OPAL (NCT01847729)
- Where
- 7 sites in France
- Volunteers
- 263 people
- Sponsor
- Nantes University Hospital
Methadone-maintenance Subjects
Study Evaluating MOA-728 in Subjects on Stable Methadone Maintenance
This is a study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MOA-728 in subjects on stable methadone maintenance.
- Trial name
- NCT00447811
- Testing
- MOA-728
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Metahdone-maintenance Subjects
Comparisons Of The Bioavailability And Pharmacodynamics Of Various Formulations Of MOA-728 In Subjects On Methadone
Primary: To determine the relative bioavailability of MOA-728, an investigational drug, administered orally in both the capsule and tablet formulations to methadone maintenance subjects.Secondary: To assess the pharmacodynamic…
- Trial name
- NCT00398502
- Testing
- MOA-728
- Where
- United States
- Sponsor
- Bausch Health Americas, Inc.
Opioid Addiction
Observational Study to Evaluate Levomethadone Safety and Effectiveness in Subjects Under Opioid Maintenance Treatment
Multicentre, prospective, observational, non-interventional, open- ended trial, collecting data from male and female patients aged ≥ 18 years, with a diagnosis of opioid addiction according to ICD-10 (F11.2), treated with…
- Trial name
- LEVOPROACT (NCT03685162)
- Where
- Italy
- Volunteers
- 103 people
- Sponsor
- L.Molteni & C. dei F.lli Alitti-Soc. di Esercizio S.p.A.