Clinical trials: Methamphetamine
Methamphetamine Metabolism, CYP2D6 Genotype
The Impact of Genetic Variation in CYP2D6 on the Pharmacokinetics and Pharmacodynamics of Methamphetamine
Methamphetamine abuse and addiction are widespread and is causing increasing pressures on social, public health and criminal justice systems worldwide. Some of the risk for developing addiction may be genetic.
- Trial name
- NCT01529892
- Testing
- A single oral 5 mg of duterium labeled methamphetamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- California Pacific Medical Center Research Institute
Methamphetamine Dependence
Pilot Study of Entacapone for Methamphetamine Abuse
Addiction to methamphetamine is a serious health problem. There are no medications that a doctor can give someone to help them stop using methamphetamine.
- Trial name
- NCT02058966
- Testing
- Entacapone, Methamphetamine
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Continuous Methamphetamine Dependence, Methamphetamine Dependence in Remission
Safety Study to Assess Atomoxetine With MA Abusers and Healthy Controls
Methamphetamine (MA) abuse is a national public health concern. People who are dependent on MA have problems with mental functions (e.g., learning, remembering, focusing attention, solving problems).
- Trial name
- NCT02014064
- Testing
- Atomoxetine
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Anxiety, Relapse
"The Evaluation of Stimulant Withdrawal"
The purpose of this research study is to determine whether Carvedilol, an FDA approved beta blocker, when administered for an 8-week period to veterans currently undergoing treatment for methamphetamine dependence (1) improves…
- Conditions
- Anxiety, Relapse, Substance Addiction
- Trial name
- MARC (NCT00442923)
- Testing
- Coreg
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aaron J. Janowsky
Methamphetamine Dependence
Intensive Motivational Interviewing for Methamphetamine Dependence
A Stage 2 randomized clinical trial (RCT) to test the efficacy of a 9-session model of motivational interviewing (MI) for methamphetamine (MA) dependence.
- Trial name
- NCT01071356
- Testing
- Intensive MI, Single session MI
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Public Health Institute, California
Methamphetamine Dependence
Safety and Tolerability of Modafinil for Methamphetamine Dependence
This 7 week, open-label pilot clinical trial will examine the safety and tolerability of modafinil up to 400mg/day as a potential treatment to reduce methamphetamine use in methamphetamine-dependent volunteers.
- Trial name
- NCT00569374
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Substance Abuse, HIV Infections
Acceptability of Pharmacologic Treatment for Methamphetamine Dependence Among MSM
Studies demonstrate that methamphetamine (meth) use is associated with high-risk sexual behavior among MSM, putting meth-using MSM at extraordinarily high risk for transmitting or acquiring HIV.
- Trial name
- NCT00318409
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
Substance-Related Disorders
DOX as a Potential Treatment for Methamphetamine Dependence
The purpose of the study is to asses the potential interactions between methamphetamine and doxazosin in methamphetamine-dependent volunteers who are not seeking treatment.
- Trial name
- DOX-Meth (NCT02785393)
- Testing
- Sugar Pill, Doxazosin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Overdose Accidental
Naltrexone for Overdose Prevention
The goal of this clinical trial is to see if an injectable medicine called naltrexone can prevent fentanyl overdose deaths in people who use other drugs (cocaine, methamphetamine).
- Trial name
- NOD (NCT06633900)
- Testing
- IM naltrexone, Usual Care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Methamphetamine Use Disorder
Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]
This study will evaluate the behavioral effects of methamphetamine during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- NCT04178993
- Testing
- Methamphetamine, Methylphenidate, Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Methamphetamine Abuse, Methamphetamine-dependence
Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic.
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
- Trial name
- NCT05854667
- Testing
- Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
- Where
- 4 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
HIV Seroconversion, Stimulant Abuse
Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men
This study seeks to evaluate the efficacy of a contingency management (CM) intervention compared to a yoked control condition for eliminating illicit stimulant use and for decreasing time to initiating post exposure prophylaxis…
- Trial name
- NCT01140880
- Testing
- Truvada
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Methamphetamine Abuse
Contingency Management for Meth in South Africa Methamphetamine Abuse in South Africa
This study will link findings from neuroscience with clinical outcomes using contingency management (CM) to identify changes in brain structure and function that emerge during purely behavioral therapy for methamphetamine (MA)…
- Trial name
- NCT02907853
- Testing
- Contingency Management
- Where
- South Africa
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Methamphetamine-dependence
Transcranial Magnetic Stimulation for Treatment of Methamphetamine Dependence
Repetitive transcranial magnetic stimulation (rTMS) was used to treat methamphetamine (MA) addiction in previous studies, while the evidence-based protocols still required.
- Trial name
- NCT03827785
- Testing
- rTMS treatment group
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Use Disorder
Cerebellum-Prefrontal Paired-Pulse Stimulation for Methamphetamine Use Disorder
To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired cerebellar-medial prefrontal cortex (mPFC) pulses on methamphetamine use disorder patients…
- Trial name
- NCT06457230
- Testing
- Paired Associative Stimulation Targeting the Cerebellar-mPFC
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Abuse, HIV/AIDS
FASTLANE II: Reducing Sex, Drug, and Mental Health Risk
The study uses a repeated measures, single group pretest-posttest design methodology to examine the feasibility, acceptability, and preliminary effectiveness of the FASTLANE II intervention aimed at decreasing risky sex behaviors…
- Conditions
- Methamphetamine Abuse, HIV/AIDS, Depression, Sex, Unsafe
- Trial name
- FLII (NCT04109014)
- Testing
- FASTLANE II
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Methamphetamine
Effectiveness of Bupropion Combined With Behavioral Therapy for Treating Methamphetamine Dependence - 2
Methamphetamine is an addictive stimulant drug that strongly activates certain parts of the brain. The purpose of this study is to determine the effectiveness of bupropion in combination with behavioral therapy for the treatment…
- Trial name
- NCT00135785
- Testing
- Bupropion
- Where
- 2 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorders, Methamphetamine Abuse
A Clinical Study to Evaluate the Safety of CS-1103 in Healthy Participants
The purpose of this Phase 1a study is to evaluate safety, tolerability, and pharmacokinetics (PK) of single, ascending doses of CS-1103, administered by intravenous (IV) infusion in healthy participants.
- Conditions
- Substance Use Disorders, Methamphetamine Abuse, Methamphetamine Intoxication
- Trial name
- NCT06316973
- Testing
- CS-1103, Sterile Saline
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Clear Scientific, Inc.
Methamphetamine Dependence
Modafinil vs Placebo for the Treatment of Methamphetamine Dependence
Modafinil is a non-amphetamine type stimulant that acts as a wakefulness-promoting drug, and is approved for managing symptoms of narcolepsy (i.e., daytime somnolence).
- Trial name
- Modafinil (NCT00469508)
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Depression, Dual Diagnosis
Open-Label Creatine Study for Female Meth Users
Study Purposes and Objectives: The objectives should be stated in such a way that the reader can determine the appropriateness of the study design. If appropriate, state the specific hypotheses being tested and/or study aims.
- Conditions
- Depression, Dual Diagnosis, Substance Use
- Trial name
- NCT02189915
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw