Clinical trials: Methamphetamine Addiction
Drug Addiction
Drug Effects on Preference and Reward
Classical conditioning is widely used to study motivational properties of addictive drugs in animals, but has rarely been used in humans.
- Trial name
- NCT01722006
- Testing
- Pairing condition
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Methamphetamine Dependence
N-Acetyl Cysteine Plus Naltrexone in Methamphetamine Dependence
The goal of the proposed study is to evaluate the efficacy and safety of N-Acetyl Cysteine (NAC) in combination with naltrexone in methamphetamine dependence.
- Trial name
- NCT00332605
- Testing
- Naltrexone plus N-Acetyl Cysteine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Chicago
Methamphetamine Dependence, Substance Abuse
Varenicline vs Placebo for the Treatment of Methamphetamine Dependence
Methamphetamine (MA) abuse is the fastest growing drug problem in the United States and is responsible for significant public health complications, including HIV infection.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- RAVEN (NCT01011829)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Methamphetamine Dependence
An Study of Paliperidone Extended-Release Tablets in the Treatment of Methamphetamine Dependence
Methamphetamine substance use is common worldwide. No approved pharmacologic treatments for methamphetamine dependence exist. paliperidone are Second generation antipsychotics，and have effects of blocking dopamine2(D2) and…
- Trial name
- NCT01825928
- Testing
- Paliperidone
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Wei Hao
Substance-Related Disorders
Flupenthixol Decanoate in Methamphetamine Smoking - 1
The purpose of this study is to evaluate the safety and efficacy of flupenthixol decanoate for treatment of methamphetamine dependence.
- Trial name
- NCT00000241
- Testing
- Flupenthixol
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine-dependence
Paired Associative Stimulation in Methamphetamine Addiction
The investigators use paired associative stimulation (PAS) protocols to target cortico-cortical and cortico-subcortical networks to study cognitive deficits in methamphetamine addiction.
- Trial name
- NCT03910608
- Testing
- MagPro X100 device (MagVenture, Farum, Denmark)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Methamphetamine-dependence
Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine Users
Addiction to methamphetamine is a serious health problem in the United States. Right now, there are no medications that a doctor can give someone to help them stop using methamphetamine.
- Trial name
- Ibudilast (NCT03341078)
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Depression, Anxiety
Creatine for Depressed Male and Female Methamphetamine Users
Assess the antidepressant/anxiolytic effect of creatine in male and female methamphetamine users Assess creatine's effect on methamphetamine use Assess the safety of creatine in male methamphetamine users with depression
- Conditions
- Depression, Anxiety, Methamphetamine Dependence
- Trial name
- NCT02568878
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Montana State University
Methamphetamine Dependence
Aripiprazole for Methamphetamine Dependence: Double Blind Placebo Trial
The purpose of this study is to test whether treatment with Aripiprazole leads to a reduction in methamphetamine craving and use in patients diagnosed with methamphetamine dependence.
- Trial name
- NCT00728312
- Testing
- Aripiprazole
- Sponsor
- US Department of Veterans Affairs
Methamphetamine Dependence, Methamphetamine Withdrawal
Characterizing Methamphetamine Withdrawal in Recently Abstinent Methamphetamine Users: A Pilot Study
Methamphetamine use has escalated in recent years. Methamphetamine use has also spread throughout the country. Although much information has been gathered on the treatment of cocaine abuse, very little information has been…
- Trial name
- NCT00653263
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Arkansas
Methamphetamine Addiction
A Pilot Trial of Dextroamphetamine for Methamphetamine Dependence
The purpose of this study is to assess the safety and effectiveness dextroamphetamine to help methamphetamine users quit or cut down on their use. The study lasts for 9 weeks.
- Trial name
- 1D (NCT00630682)
- Testing
- Dextroamphetamine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- California Pacific Medical Center Research Institute
Bipolar Disorder, Cocaine Dependence
A Randomized Control Trial Comparing Quetiapine to Risperidone in Bipolar Disorder With Stimulant Dependence
The purpose of this study is to determine whether quetiapine or risperidone are effective in treating mood symptoms, drug cravings and use in bipolar disorder with concurrent cocaine or methamphetamine dependence.
- Conditions
- Bipolar Disorder, Cocaine Dependence, Methamphetamine Dependence
- Trial name
- NCT00227123
- Testing
- quetiapine, risperidone
- Where
- 2 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Texas Southwestern Medical Center
Methamphetamine Dependence
Comparison of Methamphetamine-Dependent and Healthy Volunteers Using a Web-Enabled Cognitive Neuropsychological Evaluation System
The purpose of this study is to develop the technology infrastructure for a mobile Web-based cognitive and neuropsychological assessment of substance abusers, and to perform a pilot trial using neurocognitive tasks designed to…
- Trial name
- 5I (NCT01919437)
- Testing
- Web-Enabled Cognitive Neuropsychological Evaluation System
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- California Pacific Medical Center Research Institute
Methamphetamine Dependence, Substance Abuse
RTI-336 as a Treatment for Methamphetamine Dependence
The purpose of this study is to evaluate the safety and efficacy of RTI-336 as a treatment for methamphetamine (METH) dependence in non-treatment-seeking METH-dependent volunteers.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- NCT01601717
- Testing
- RTI-336
- Sponsor
- Baylor College of Medicine
Opioid-Related Disorders, Stimulant-Related Disorder
Preventing Parental Opioid and/or Methamphetamine Addiction Within DHS-Involved Families: PRE-FAIR
Young parents aged 16 to 30, involved in the DHS system for child welfare or self-sufficiency needs are at risk for opioid use disorder and/or methamphetamine use disorder (OUD; MUD).
- Conditions
- Opioid-Related Disorders, Stimulant-Related Disorder, Child Neglect, Mental Health Impairment
- Trial name
- PRE-FAIR (NCT05380440)
- Testing
- Prevention Adaptation of Families Actively Improving Relationships (PRE-FAIR), Standard Case Management and Referral
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Methamphetamine Dependence
Phase 2, Double-Blind, Placebo-Controlled Trial of Bupropion for Methamphetamine Dependence
This study is to assess the efficacy of bupropion in reducing methamphetamine use in subjects with methamphetamine dependence who report using methamphetamine 29 or less days during the 30 days prior to the start of signing…
- Trial name
- NCT00687713
- Testing
- Bupropion
- Where
- 12 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine Dependence, Cocaine Dependence
PHASE IIA: Trial of a Novel Ondansetron Formulation (OND-PR002) and Immediate-Release Methylphenidate (Ritalin®)(OND003IND)
The main purpose of this study is to determine the outcome of a drug combination treatment on detoxified and stabilized methamphetamine (METH) and/or cocaine (COC) dependent users.
- Trial name
- NCT01377662
- Testing
- OND-PR002 and MPh-IR
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Tong Lee
Methamphetamine Dependence, Methamphetamine Abuse
Safety Assessment of Potential Interactions Between IV Methamphetamine and Osmotic-Release Methylphenidate (OROS-MPH)
This is a human inpatient clinical pharmacology study to assess potential interactions between intravenous (i.v.) methamphetamine infusion and oral osmotic release methylphenidate (OROS-MPH).
- Trial name
- NCT00603434
- Testing
- OROS-MPH
- Where
- 2 sites in United States, Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Methamphetamine Dependence
Phase 1 Naltrexone-Bupropion-Methamphetamine Interaction Study
The study is to primarily measure safety and interactions between oral doses of Naltrexone/Bupropion and i.v. Methamphetamine.
- Trial name
- NCT01359930
- Testing
- Naltrexone and Bupropion SR
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine Dependence in Remission
The Efficacy of N-acetylcysteine Versus Placebo for the Treatment of Metamphetamine Withdrawal Symptoms
Up to date, no approved medications are available for the treatment of methamphetamine addiction. Recently, N-acetylcysteine is recently being studied for methamphetamine withdrawal.
- Trial name
- NCT04405193
- Testing
- N-acetyl cysteine
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Melva Louisa