Clinical trials: Methamphetamine Use Disorder, active
Methamphetamine Use Disorder, Substance Use Disorder
Closed-loop TBS Targeting rPO for the Core Clinical Features of Methamphetamine Use Disorder
The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use…
- Conditions
- Methamphetamine Use Disorder, Substance Use Disorder, Cue-reactivity, Craving
- Trial name
- NCT07775807
- Testing
- Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Abuse, Methamphetamine-dependence
Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic.
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
- Trial name
- NCT05854667
- Testing
- Treatment as Usual plus lisdexamfetamine (LDX-01), Treatment as Usual plus lisdexamfetamine (LDX-01) plus Contingency Management
- Where
- 4 sites in Canada
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Methamphetamine Use Disorder
Psilocybin for Methamphetamine Addiction
The primary purpose of this study is to preliminarily determine if the use of psilocybin to promote abstinence from methamphetamine is feasible and well tolerated in populations such as those found in Northern Louisiana.
- Trial name
- NCT06899594
- Testing
- Psilocybin 25 mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kevin Murnane
Methamphetamine Use Disorder
Cerebellum-Prefrontal Paired-Pulse Stimulation for Methamphetamine Use Disorder
To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired cerebellar-medial prefrontal cortex (mPFC) pulses on methamphetamine use disorder patients…
- Trial name
- NCT06457230
- Testing
- Paired Associative Stimulation Targeting the Cerebellar-mPFC
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
HIV -1 Infection, Methamphetamine Use
Short-term Effects of Methamphetamine on Residual Latent HIV Disease Study
The most commonly used illicit stimulant in people with HIV (PWH) is methamphetamine (MA). Prior studies demonstrate strong evidence that MA promotes increased HIV transcription as well as immune dysregulation.
- Trial name
- EMRLHD (NCT07584369)
- Testing
- Oral Methamphetamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Caregiver Burden in Methamphetamine Use Disorder, Expressed Emotions in Caregivers
Effectiveness of Stress Management Training Program For Expressed Emotions in Caregivers of Drug Induced Psychosis Patients Specially Methamphetamine
The main purpose of this study is to evaluate the effectiveness of a Stress Management Training (SMT) program in reducing stress levels among caregivers of individuals suffering from methamphetamine ("ice") addiction and…
- Conditions
- Caregiver Burden in Methamphetamine Use Disorder, Expressed Emotions in Caregivers, Stress Cause Expressed Emotion and Burden
- Trial name
- NCT07714642
- Testing
- O'Connor's (2003) Stress Management Training
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
PrEP Adherence, Methamphetamine Use Disorder
CHAMPION: Combining HIV And Meth Prevention and Treatment Interventions Optimized for HIV-Negative MSM
The goal of this randomized controlled trial is to pilot test new mobile health (mHealth) interventions to improve PrEP adherence among HIV-negative men who have sex with men (MSM) with mild to moderate methamphetamine use…
- Conditions
- PrEP Adherence, Methamphetamine Use Disorder, HIV
- Trial name
- CHAMPION (NCT07213258)
- Testing
- CHAMPION Intervention, Delayed CHAMPION Package
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Stimulant Use Disorder
Orexin Receptor Antagonism and Sleep in Stimulant Use Disorder
The purpose of this study is to determine the effects of suvorexant (SUVO), on sleep, stress, and drug craving during early abstinence from stimulants and to determine the effects of treatment (SUVO vs.
- Trial name
- NCT06444256
- Testing
- SUVO, TAU
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Methamphetamine-dependence, Methamphetamine Abuse
Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder
The primary objective of this study is to evaluate the efficacy of extended release naltrexone plus bupropion XL (XR-NTX/BUP-XL) compared to matched injectable and oral placebo (iPLB/oPLB) in reducing methamphetamine (MA) use in…
- Trial name
- NCT06233799
- Testing
- extended-release naltrexone (XR-NTX), extended release bupropion (BUP-XL) tablets (BUP-XL), iPLB
- Where
- 11 sites in United States
- Volunteers
- 360 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Methamphetamine Disorders
Reliability, Validity, and Acceptability of a Novel Visual Scale for Estimating Daily Methamphetamine Use Among People Who Use Methamphetamine
PROJECT RESIN: This study is examining the reliability, validity, and acceptability of a novel visual scale for estimating daily methamphetamine use among people who use methamphetamine.
- Trial name
- PROJECT RESIN (NCT07464873)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Phillip Coffin, MD, MIA
Methamphetamine Use Disorder, Pregnancy
Transcranial Magnetic Stimulation for Methamphetamine Use Disorder During Pregnancy
The goal of this clinical trial is to learn whether transcranial magnetic stimulation, also called TMS, is a practical and acceptable treatment option for methamphetamine use disorder during pregnancy.
- Trial name
- NCT07849530
- Testing
- 4- Week Dual-Target Transcranial Magnetic Stimulation (TMS), Accelerated Dual-Target Transcranial Magnetic Stimulation (aTMS), Treatment as Usual (TAU)
- Volunteers
- 45 people
- Sponsor
- University of Utah
Methamphetamine Use Disorder
Non-Abstinence Outcomes in Methamphetamine Use Disorder
Reduced drug use is a clinically meaningful target for treatment development, but few studies have evaluated the positive impacts produced by this behavioral change, preventing adoption of this endpoint in clinical trials.
- Trial name
- RCT (05) (NCT07226596)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- William Stoops
Methamphetamine Intoxication, Methamphetamine Disorders
A Single-Dose Study to Evaluate Safety and Efficacy of CS-1103 in Participants Receiving a Single Dose of Methamphetamine
The purpose of the study is to evaluate the safety, efficacy, and pharmacokinetics of four single, increasing doses of CS-1103, given by intravenous (IV) infusion in otherwise healthy, non-treatment seeking participants with…
- Conditions
- Methamphetamine Intoxication, Methamphetamine Disorders, Methamphetamine Abuse
- Trial name
- NCT06721494
- Testing
- Methamphetamine, Sterile Saline, CS-1103
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Clear Scientific, Inc.
Amphetamine Use Disorders
Closed-loop tTIS Targeted of the Nac as an Intervention for MUD Patients
Closed-loop transcranial temporal interference stimulation (tTIS) targeting the nucleus accumbens may modulate abnormal neural responses to drug-related cues in individuals with methamphetamine use disorder (MUD), thereby…
- Trial name
- NCT07802223
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Abuse, Methamphetamine-dependence
Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder
Methamphetamine use disorder (MUD) is becoming an increasing public health concern in Canada. While the evidence on the efficacy and safety of prescription psychostimulants for the treatment of MUD is promising, the knowledge on…
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance Abuse
- Trial name
- NCT06788587
- Testing
- LDX-01 plus TAU
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Amphetamine-Related Disorders
Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder
This is a proof-of-concept randomized clinical trial of psilocybin-enhanced psychotherapy versus treatment-as-usual among individuals being treated for methamphetamine use disorder.
- Trial name
- NCT04982796
- Testing
- Psilocybin, Treatment-as-usual
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Portland VA Research Foundation, Inc
Methamphetamine Use, Heart Failure
Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement
The goal of PEER-Heart is to implement and assess feasibility and preliminary effectiveness of a community peer-facilitated screening for methamphetamine-associated heart failure (MAHF) and linkage to evidence-based cardiology…
- Trial name
- PEER-Heart (NCT06461962)
- Testing
- Treatment as Usual, Telehealth-Cardiology
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Methamphetamine Induced Psychosis, Cannabis Use
Psychiatric Symptom Characteristics in Methamphetamine-Induced Psychosis With and Without Lifetime Cannabis Use
This prospective cohort study aims to investigate factors associated with psychiatric symptom severity in participants diagnosed with methamphetamine-induced psychotic disorder (MP) with and without lifetime cannabis use (LCU).
- Trial name
- NCT07459270
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital
Methamphetamine Use Disorder, Human Immunodeficiency Virus (HIV)
Psilocybin Therapy for Methamphetamine Use Disorder and HIV
The goal of this clinical trial is to learn whether it is possible to use psilocybin in combination with motivational support therapy to treat moderate-to-severe methamphetamine use disorder (MeUD) in people with HIV who are…
- Trial name
- PRISM (NCT07756736)
- Testing
- Psilocybin 5 mg, Psilocybin 25 mg, Motivational Support
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Nicky Mehtani, MD, MPH
Methamphetamine Use Disorder
Methamphetamine Cue-reactivity
In this observational cohort study, the researchers propose to first identify a psychophysiological marker of methamphetamine cue-reactivity and its incubation with abstinence from methamphetamine use (MUD) and examine…
- Trial name
- NCT07086014
- Testing
- Cognitive Reappraisal
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Icahn School of Medicine at Mount Sinai