Clinical trials: Methotrexate
Rheumatoid Arthritis
Study of Adalimumab Administered as Subcutaneous Injections in Adult Chinese Rheumatoid Arthritis Subjects Treated With Methotrexate
A Randomized, Double-Blind, Placebo-Controlled, Study of the Adalimumab Administered as Subcutaneous Injections in Adult Chinese Rheumatoid Arthritis Subjects Treated with Methotrexate
- Trial name
- NCT00647920
- Testing
- adalimumab
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- Abbott
Rheumatoid Arthritis, Exposed to TBE-virus
TBE-vaccine to Patients With Rheumatoid Arthritis Who Are Using Immunosuppressive Drugs
The investigators intend to check whether the efficacy of a TBE-vaccine is substantially deteriorated in patients with rheumatoid arthritis who are treated with drugs which suppress the immune system.
- Conditions
- Rheumatoid Arthritis, Exposed to TBE-virus, Immunosuppression
- Trial name
- NCT01131910
- Testing
- TBE-vaccine, Vaccination against TBE
- Where
- 6 sites in Finland, Sweden
- Volunteers
- 68 people
- Sponsor
- Sormland County Council, Sweden
Inflammation, Aging
Inflammation Control For Elders: ICE Study
This study will be the first to test whether a selected anti-inflammatory agent, methotrexate, reduces inflammation in a human body, improve cognitive and physical function, and reduce pain levels in older adults at risk for…
- Trial name
- ICE (NCT02079948)
- Testing
- Methotrexate + Folic Acid, Functional MRI Experimental Tasks, Muscle Biopsy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Rheumatoid Arthritis
A Retrospective, Observational Chart Review of Biologics in Monotherapy Versus the Combination Biologic Plus Methotrexate in Patients With Rheumatoid Arthritis
This cross-sectional, non-interventional, retrospective chart review will compare the efficacy and safety of biologic monotherapy and biologic and methotrexate combination therapy in patients with rheumatoid arthritis who have…
- Trial name
- NCT01866150
- Where
- 15 sites in United Kingdom
- Volunteers
- 476 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Remission and Joint Damage Progression in Early Rheumatoid Arthritis
This is a world wide study to evaluate the remission and joint damage in subjects treated with abatacept in addition to methotrexate versus subjects who receive methotrexate along with a placebo.
- Trial name
- NCT00122382
- Testing
- Abatacept, methotrexate
- Where
- 89 sites in United States, Australia and 16 more
- Volunteers
- 1,052 people
- Sponsor
- Bristol-Myers Squibb
Methotrexate Adverse Reaction, Advantage of Using Subcutaneous Route for Methotrexate
Subcuteous Methotrexate in Rheumatoid Arthritis
Methotrexate use is important for the treatment of Rheumatoid arthritis. Some patients can not tolerate oral methotrexate. So subcutaneous may help to overcome it.
- Trial name
- SCMTXRA (NCT07094880)
- Testing
- Tab. Methotrexate 25mg/week, Inj. Methotrexate 25mg/week
- Volunteers
- 45 people
- Sponsor
- Bangladesh Medical University
Graves Ophthalmopathy
Thyroid Treatment Trial
This project will compare the efficacy and safety of 2 methods of disease modification in the treatment of active moderate and severe thyroid orbitopathy.
- Trial name
- NCT00348413
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- Singapore National Eye Centre
Localized Psoriasis
Intralesional Injection Of Methotrexate Versus Triamcinolone Acetonid In Treatment Of Localized Psoriasis
The aim of the present study is to evaluate the efficacy of intralesional injection of methotrexate in comparison with Intralesional Injection of Triamcinolone Acetonid in localized psoriasis (body surface area < 10%) .
- Trial name
- NCT05408208
- Testing
- Intralesional Injection of Methotrexate, Triamcinolone Acetonid
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sohag University
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Combination Chemotherapy in Patients With Newly Diagnosed BPDCN
Patients with suspected BPDCN and meeting eligibility criteria will be enrolled in the study. First, BPDCN diagnosis will be confirmed by anatomic pathology (Dr Petrella T, Montreal) and cytologic plus immunophenotyping analysis…
- Trial name
- LpDessai (NCT03599960)
- Testing
- Chemotherapy
- Where
- 2 sites in France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Rheumatoid Arthritis
Study to Assess the Short- and Long-term Efficacy of Certolizumab Pegol Plus Methotrexate Compared to Adalimumab Plus Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis (RA) Inadequately Responding to Methotrexate
This study is conducted to evaluate the short (12 Weeks) and long term (104 Weeks) efficacy of Certolizumab Pegol compared with Adalimumab both in combination with Methotrexate (MTX) in the treatment of moderate to severe…
- Trial name
- NCT01500278
- Testing
- Certolizumab Pegol (CZP), Adalimumab (ADA), Methotrexate (MTX)
- Where
- 175 sites in United States, Australia and 18 more
- Volunteers
- 915 people
- Sponsor
- UCB Pharma SA
Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia
Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia
This randomized phase III trial is studying dexamethasone to see how well it works compared to prednisone during induction therapy.
- Conditions
- Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia, Childhood B Acute Lymphoblastic Leukemia
- Trial name
- NCT00075725
- Testing
- Cyclophosphamide, Cytarabine, Daunorubicin Hydrochloride
- Where
- 234 sites in United States, Australia and 3 more
- Volunteers
- 3,154 people
- Sponsor
- Children's Oncology Group
Survival Without Progression
A Clinical Trial Using Metronomic Oral Low-dose Cyclophosphamide Alternating With Low-dose Oral Methotrexate With Continuous Celecoxib and Weekly Vinblastine in Children and Adolescents With Relapsed or Progressing soliD Tumours.
To establish the anti-tumour effect of this metronomic combination regimen defined by progression-free survival (PFS) after two cycles of treatment (4 months) and 12 months of treatment, as well as response rate after any number…
- Trial name
- SFCE METRO 01 (NCT01285817)
- Testing
- celecoxib, Vinblastine, Cyclophosphamide , methotrexate ,
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Psoriasis
Evaluation of the Effect of Narrowband UVB Versus Methotrexate on Serum Chitotriosidase Level in Psoriasis
The aim of the study is to evaluate the effect of NB-UVB versus MTX on serum Chitotriosidase level in psoriatic patients.
- Trial name
- NCT05427175
- Testing
- Narrowband ultraviolet B, Methotrexate
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Rheumatoid Arthritis
Study Evaluating TMI-005 in Active Rheumatoid Arthritis
The primary objective of this clinical research study is to compare the efficacy and the safety of 3 dose levels of oral TMI-005 in comparison with placebo in subjects with active Rheumatoid Arthritis (RA) who have been receiving…
- Trial name
- NCT00095342
- Testing
- TMI-005
- Where
- 8 sites in United States, Canada
- Volunteers
- 390 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis
A Rheumatoid Arthritis Study in Participants on a Background Treatment of Methotrexate
The primary purpose of this study is to help answer if LY2127399 is safe and effective in the treatment of rheumatoid arthritis while on a background treatment of methotrexate.
- Trial name
- FLEX M (NCT01198002)
- Testing
- LY2127399, Methotrexate
- Where
- 234 sites in United States, Argentina and 21 more
- Volunteers
- 1,041 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
Study to Assess Efficacy of Tacrolimus + Methotrexate Versus Placebo + Methotrexate in Treatment of Rheumatoid Arthritis
The purpose of this study is to evaluate the efficacy of the combination of tacrolimus + methotrexate compared to methotrexate alone in the treatment of the signs and symptoms of rheumatoid arthritis over 6 months in patients…
- Trial name
- NCT00036153
- Testing
- Tacrolimus (Prograf®), Methotrexate
- Where
- 45 sites in United States, Canada
- Volunteers
- 210 people
- Sponsor
- Astellas Pharma Inc
Rheumatoid Arthritis
A 6-month Randomised, Double-blind, Open Arm Comparator, Phase IIb, With AZD9056, in Patients With Rheumatoid Arthritis (RA)
The purpose of this study is to confirm that AZD9056 is effective in treating rheumatoid arthritis with regard to signs and symptoms and to determine what dose is favourable over a 6-month treatment period.
- Trial name
- NCT00520572
- Testing
- AZD9056, Etanercept
- Where
- 51 sites in United States, Argentina and 10 more
- Volunteers
- 385 people
- Sponsor
- AstraZeneca
Immunodeficiency
Donor Lymphocyte Infusion After Alternative Donor Transplantation
The purpose of this study is to determine the ability of a donor lymphocyte infusion (DLI) given with methotrexate to hasten immune recovery without causing severe graft-versus-host disease (GVHD) in recipients who have had a…
- Trial name
- NCT01027702
- Testing
- Infusion of donor lymphocytes
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Wake Forest University Health Sciences
Rheumatoid Arthritis
Association Between Methotrexate Erythrocyte Polyglutamate Concentration and Clinical Response in Rheumatoid Arthritis Patients Treated With Subcutaneous Injectable Methotrexate
Methotrexate (MTX) is the first-line treatment of rheumatoid arthritis (RA). In case of MTX failure, it is discussed to start a Biologic Disease-modifying Antirheumatic Drug (bDMARDs) according to the latest European…
- Trial name
- POLYGLU (NCT03445871)
- Testing
- Blood sample, CRQ
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Rheumatoid Arthritis
A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Agents.
This single arm study will assess the safety and efficacy of MabThera in combination with methotrexate in patients with rheumatoid arthritis who have had an inadequate response or intolerance to one or more anti-TNF agents.
- Trial name
- NCT00504777
- Testing
- rituximab [MabThera/Rituxan], Methotrexate
- Where
- 10 sites in Taiwan
- Volunteers
- 36 people
- Sponsor
- Hoffmann-La Roche