Clinical trials: Methylphenidate
Healthy
Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans
The study looks into whether administering psychedelic substances that stimulate the serotonin system influences pro-social behavior when compared to administering substances that stimulate the dopamine system in healthy…
- Trial name
- NCT06081179
- Testing
- Psilocybin, 3,4 Methylenedioxymethamphetamine, Methylphenidate
- Where
- Switzerland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Drug Binding to DAT Receptors
Study of Dopamine Transporter Receptor Occupancy With Long-acting Dex-methylphenidate
The objectives of this study are to document the pharmacokinetics of the adequacy of DAT receptor occupancy d-MPH formulation in three doses (20 mg, 30 mg, and 40 mg) using PET scanning with C-11 Altropane as the ligand across a…
- Trial name
- NCT00593138
- Testing
- dex-methylphenidate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Methamphetamine Dependence, Methamphetamine Abuse
Safety Assessment of Potential Interactions Between IV Methamphetamine and Osmotic-Release Methylphenidate (OROS-MPH)
This is a human inpatient clinical pharmacology study to assess potential interactions between intravenous (i.v.) methamphetamine infusion and oral osmotic release methylphenidate (OROS-MPH).
- Trial name
- NCT00603434
- Testing
- OROS-MPH
- Where
- 2 sites in United States, Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Attention Deficit Hyperactivity Disorder
Gene-environment Interactions and Brain Functional Connectivity in Attention Deficit Hyperactivity Disorder
The aims of the current study are to examine gene-environment interactions associated with norepinephrine (NE) system genes (ADRA2A, SLC6A2) in ADHD, and to evaluate whether genetic changes in norepinephrine pathway are…
- Trial name
- NCT01912352
- Testing
- Methylphenidate
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Dopamine Activity, Episodic Memory Consolidation
Dopaminergic Modulation of Cognition and Psychomotor Function
A recent study at our lab showed increased episodic memory consolidation and response readiness after treatment with methylphenidate in healthy volunteers. The investigators seek to replicate and extend these findings.
- Conditions
- Dopamine Activity, Episodic Memory Consolidation, Response Preparation
- Trial name
- NCT01218425
- Testing
- Methylphenidate 40 mg, Levodopa/carbidopa 125 mg, Domperidon 10 mg
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
Sensitivity of Project: EVO Monitor Cognitive Measurements to Pharmacological Agents
This is a study in adults to assess the sensitivity of Project: EVO Monitor cognitive measurements to two short-acting cognitively active pharmacological agents.
- Trial name
- NCT02822937
- Testing
- Methylphenidate, Triazolam, Project: EVO
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Akili Interactive Labs, Inc.
Attention Deficit Hyperactivity Disorder
Effect Of Methylphenidate On Balance In Children With Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder is a neurodevelopmental disorder that may have poor motor coordination and balance control. The effect of Methylphenidate treatment on balance and fall risk is still unclear.
- Trial name
- NCT05522478
- Testing
- Fall risk
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Attention Deficit Hyperactivity Disorder (ADHD)
Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects
The aim of the ADDUCE project is to investigate any adverse effects of methylphenidate (trade name ritalin) on growth, neurological system, psychiatric states and cardiovascular system over a two year period in children and…
- Trial name
- ADDUCE (NCT01470261)
- Where
- 4 sites in Germany, Hungary and 2 more
- Volunteers
- 1,398 people, healthy volunteers welcome
- Sponsor
- NHS Tayside
Attention Deficit Hyperactivity Disorder
Efficacy of Combined Treatment With CoQ10 and Methylphenidate in Children With Attention Deficit Hyperactivity Disorder
The aim of this study is to evaluate the effects of nutritional supplement co-enzyme Q10 (CoQ10) on methylphenidate-treated ADHD children in a randomized, double-blinded, placebo-controlled prospective study.
- Trial name
- NCT02315651
- Testing
- Coenzyme Q10
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Healthy Volunteers
Methylphenidate and Cognitive Training in Elderly
Currently, there is no available drug to treat the symptoms of neurodegenerative and vascular cognitive disorders that affect millions of people worldwide.
- Trial name
- PACTE-1 (NCT03280251)
- Testing
- Methylphenidate, CogniPlus software, Pseudo cognitive training
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Hypothermia, Exercise Test
The Role of Methylphenidate on Performance in the Cold
The purpose is to study the effects of dopamine activity, using methylphenidate ingestion, on exercise and cognitive function over the course of a progressive cooling protocol.
- Conditions
- Hypothermia, Exercise Test, Cognition
- Trial name
- NCT04283877
- Testing
- Methylphenidate
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brock University
Attention Deficit Hyperactivity Disorder
Effect of Methylphenidate on Connectivity
The goal of the study is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate.
- Trial name
- NCT01764672
- Testing
- Methylphenidate
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Iris Sommer
Attention-Deficit/Hyperactivity Disorder
SNAP 25 Gene Study
To enhance our capacity to correctly choose the appropriate medication for ADHD patients on the first try based on the presence of a particular variant of a gene that could be identified on a laboratory test.
- Trial name
- NCT00885560
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Carboxylesterase 1 (CES1) Genotype, CES1 Activity
Impact of CES1 Genotype on Metabolism of Methylphenidate
The purpose of this study is to determine whether differences in the gene coding for the liver enzyme carboxylesterase 1 (CES1) means differences in the metabolism of methylphenidate, a CES1 dependent drug.
- Trial name
- NCT02147535
- Testing
- Methylphenidate
- Where
- Denmark
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Healthy
Open-label, Normal Healthy Volunteer Clinical Trial of a Novel Ondansetron Formulation
The goals of this open-label Phase Ia study are to evaluate the Pharmacokinetics (PK) profiles of new novel single-dose Ondansetron Pulsatile Release (Ond-PR) formulations in normal healthy volunteers.
- Trial name
- NCT01290276
- Testing
- Ond-PR1, Ond-PR1 + MPh-IR, Ond-PR2
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Tong Lee
Attention Deficit Hyperactivity Disorder, ADHD
Imaging Stimulant and Non Stimulant Treatments for ADHD: A Network Based Approach
The growing number of medications used to treat attention-deficit/hyperactivity disorder (ADHD) raises important questions about whether different medications have similar or different therapeutic mechanisms of action.
- Trial name
- NCT01678209
- Testing
- fMRI scans, Atomoxetine arm, Methylphenidate arm
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Psychoactive Substances Consumption, Substance-related Disorder
French Study on COgnitive Enhancement and Consumption of Psychoactive Substances Among Youth Students
This descriptive and declarative study will help to find out consumption rates, all psychoactive substances taken together, among 18-25 year olds.
- Conditions
- Psychoactive Substances Consumption, Substance-related Disorder, Off Label-use, Cognitive Enhancement
- Trial name
- ENQUETE-COSYS (NCT02954679)
- Testing
- Online self-administrated and anonymous survey questionnaire
- Where
- France
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pharmacological Action (PA)
The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects
1. To examine whether Ritalin has analgesic properties in healthy subjects. 2. To examine if Ritalin analgesic effect is a pain specific phenomenon or a part of a broader, non-specific effect on high mental functions.
- Trial name
- NCT01914822
- Testing
- methylphenidate hydrochloride
- Where
- Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Carboxylesterase 1 (CES1) Genotype, CES1 Activity
Metabolism of Methylphenidate and Enalapril Based on CES1 Genotype
The purpose of this study is to determine whether differences in the gene coding for the liver enzyme carboxylesterase 1 (CES1) means differences in the metabolism of two CES1 dependent drugs, enalapril and methylphenidate.
- Trial name
- NCT02135263
- Testing
- Methylphenidate, Enalapril
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Pain
Neural Correlates of Acute Pain Dynamics
This work aims to study the neural correlates and determinants of pain dynamics related to changes in a noxious stimulus.
- Trial name
- NCT05669924
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University