Clinical trials: Methylphenidate
Healthy Adult Male and Female Volunteers
Neurocognitive Effects of Extended-Release Methylphenidate in Healthy Adults
This study evaluated the effects of methylphenidate (MPH), a stimulant medication commonly used to treat attention deficit hyperactivity disorder (ADHD), in healthy adults without ADHD.
- Trial name
- NCT07742631
- Testing
- Methylphenidate Stimulant medication therapy
- Where
- South Africa
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Healthy Volunteers
An Open Label Phase I/II Study of Dopamine Transporter Receptor Occupancy With OROS and Immediate Release Methylphenidate as Measured With C-11 Altropane in Human Subjects
The specific aim of this study is to document the pharmacokinetics of DAT receptor occupancy of OROS and immediate release (IR) MPH using PET scanning with C-11 altropane as the ligand.
- Trial name
- NCT00302367
- Testing
- OROS methylphenidate hydrochloride, immediate release methylphenidate hydrochloride
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alcohol Use Disorder
Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- BED[IN]:36 (NCT03575403)
- Testing
- Alcohol, Duloxetine (60 MG), Methylphenidate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Attention Deficit Hyperactivity Disorder
The Effect of Methylphenidate Versus Placebo on State Anxiety in Children With Attention Deficit Hyperactivity Disorder.
The purpose of the study is to explore the effect of methylphenidate on state anxiety in children with attention deficit hyperactivity disorder.
- Trial name
- NCT01798459
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Attention Deficit Hyperactivity Disorder
OT and Social Cognition in Children With ADHD: Impact of MPH
Background: The current study aimed to explore the possible effect of stimulants on oxytocin (OT), a neuropeptide found to regulate social behavior, as a mediator of the pro-social effect of methylphenidate (MPH) in children with…
- Trial name
- NCT03788902
- Testing
- Ritalin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Attention Deficit Hyperactivity Disorder
Endocrine Disrupting Chemicals and Hormones in ADHD
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. Growth hormone and thyroid function are associated with both physical and neurocognitive development.
- Trial name
- ADHD (NCT04970303)
- Testing
- Methylphenidate
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Methamphetamine Use Disorder
Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]
This study will evaluate the behavioral effects of methamphetamine during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- NCT04178993
- Testing
- Methamphetamine, Methylphenidate, Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Cocaine Use Disorder
Methylphenidate-Duloxetine Combinations for Cocaine Dependence
This study will determine the influence of methylphenidate (e.g., Ritalin®) and duloxetine (Cymbalta®), alone and in combination, on the cocaine use as measured by self-report and urine drug screens.
- Trial name
- NCT02700711
- Testing
- Methylphenidate, Duloxetine
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Healthy
Behavioral Differences in Effortful Control
Effortful control refers to the mental processes that help a person to regulate his or her own attention, thoughts, and emotions.
- Trial name
- BDEC (NCT01852344)
- Testing
- Methylphenidate, Easy Behavioral Task, Hard Behavioral Task
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Michigan
ADHD
The Effects of a Single Dose of Methylphenidate on Motor Performance
Aim: To evaluate the effects of MPH on young adults diagnosed with ADHD on different exercise performance tests. Hypothesis: MPH will have positive effects on motor tests requiring concentration.
- Trial name
- NCT04283604
- Testing
- MPH
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Loewenstein Hospital
Language, Methylphenidate of Undetermined Intent
Language & Cognitive Control
Catecholamine (CA) neurotransmitters, such as dopamine (DA) and noradrenaline (NA), have long been implicated playing a critical role in cognitive functions, such as working memory (WM), inhibition, learning, and decision making.
- Trial name
- LCCMPH (NCT05272397)
- Testing
- Methylphenidate 20 Mg Oral Tablet, Language Task, Rest Recording
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Donders Centre for Cognitive Neuroimaging
Smoking, ADHD
Neuroimaging of Smokers With and Without Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this study is to evaluate how nicotine, withdrawal from nicotine, and methylphenidate (a drug used for the treatment of ADHD) affect the brain of smokers with and without ADHD while doing tasks in an functional…
- Trial name
- NCT01123668
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Duke University
PTSD
Effects of Methylphenidate (Ritalin®) on the Neural Basis of Anxiety
In the present study, investigator will investigate the effects of methylphenidate (40 mg) on mPFC activity in healthy male volunteers during fear extinction using functional magnetic resonance imaging (fMRI).
- Trial name
- NCT02021214
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Epilepsy, Cognitive Deficits
Methylphenidate Treatment of Attention Deficits in Epilepsy
Methylphenidate (MPH) has long been used to improve attention and cognitive difficulties associated with ADHD, including in children with ADHD and epilepsy (Torres et al., 2008).
- Conditions
- Epilepsy, Cognitive Deficits, Attention Deficits
- Trial name
- NCT02178995
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Kimford Jay Meador
Attention Deficit Hyperactivity Disorder
Evaluation of the Effect Foquest® on Sleep in Children Aged 6-12 With ADHD
The purpose of this study is to evaluate the effect of Foquest® on sleep, using actigraphy and sleep diaries, in children aged 6-12 compared to baseline on no medication.
- Trial name
- NCT04741516
- Testing
- Foquest
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- JPM van Stralen Medicine Professional
Cocaine Dependence
Understanding Dopamine Mechanisms in Cocaine Addiction Using AMPT and Methylphenidate With [11C]RAC/[11C]PHNO PET
Studies using positron emission tomography (PET) have been used with great success in demonstrating specific abnormalities in several facets of dopaminergic system function in human populations (Narendran and Martinez 2009).
- Trial name
- NCT02152670
- Testing
- Methylphenidate, Alpha Methyl Para Tyrosine (AMPT), [11C]PHNO
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Yale University
Attention Deficit Hyperactivity Disorder (ADHD)
The Effect of Methylphenidate Treatment on Oxidative Stress Levels in Children Diagnosed With Attention Deficit Hyperactivity Disorder (ADHD)
The aim of this study is to investigate the effect of methylphenidate treatment on oxidative stress by measuring the levels of Total Oxidant Status (TOS), Total Antioxidant Status (TAS), Oxidative Stress Index (OSI=TOS/TAS)…
- Trial name
- NCT06844812
- Testing
- This is not an interventional study. Patients who are planned to start methylphenidate treatment have been invited to participate in the study.
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Posttraumatic Stress Disorder
Efficacy of Reboxetine and Methylphenidate Treatment on Attentional, Sensory and Emotional Dysregulation in Adults With PTSD
Up-to-date, no studies have examined the attentional, sensory and emotional processing (difficulties) among patients diagnosed with Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT05133804
- Testing
- Methylphenidate, Reboxetine
- Where
- 3 sites in Israel
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Acute Lymphoblastic Leukemia, Brain Tumors
Learning Impairments Among Survivors of Childhood Cancer
Children surviving some types of cancer have a higher risk of developing learning problems after cancer treatment than do children who have not had cancer or its treatment.
- Trial name
- NCT00576472
- Testing
- Methylphenidate
- Where
- 3 sites in United States
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Attention Deficit/Hyperactivity Disorder
International Study to Predict Optimised Treatment in Attention Deficit/Hyperactivity Disorder
The aim of the iSPOT-A study is to: 1. identify brain, genetic and cognitive markers of Attention Deficit/Hyperactivity Disorder, and 2.
- Trial name
- NCT00863499
- Testing
- Short Acting Methylphenidate, Long Acting Methylphenidate
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 1,344 people, healthy volunteers welcome
- Sponsor
- BRC Operations Pty. Ltd.