Clinical trials: MicroRNAs
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Complex Regional Pain Syndrome Type I
Longitudinal Follow-up Study About Complex Regional Pain Syndrome (CRPS) Patients
Complex regional pain syndrome (CRPS) is a post-traumatic chronic pain condition characterized by pain and other symptoms typically affecting a distal limb.
- Trial name
- NCT04703647
- Testing
- Administration of questionnaires for prospective group, Blood samples for prospective group, Blood samples for control group
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Lymphangioleiomyomatosis
Discovery of Sirolimus Sensitive Biomarkers in Blood
Background: Lymphangioleiomyomatosis (LAM) is a rare, progressive disease. It usually affects women in the prime of their lives. It typically results in lung destruction.
- Trial name
- NCT03304678
- Testing
- Sirolimus 2mg
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Bypass Grafting (CABG) Surgery, Myocardial Protection
Impact of Different Cardioplegia Solutions on Indicators of Myocardial Injury During Coronary Surgery
The aim of the present study is to investigate intra-operative changes in markers of myocardial injury during ischemia and reperfusion, comparing three methods of myocardial protection; St.
- Trial name
- Cardioplegia2 (NCT07358221)
- Testing
- The intervention is the use of a specific cardioplegia solution for myocardial protection
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Damascus University
Pulmonary Cancer
Quantification of microRNAs in Diagnosis of Pulmonary Nodules
One of the main challenges of thoracic oncology lies in earlier diagnosis of lung cancer to improve survival rate, wich is about 15% at 5 years. This poor prognosis is often linked to late diagnosis.
- Trial name
- miR-Nod (NCT03293433)
- Testing
- Blood punction
- Where
- 2 sites in France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Toulouse
Heart Failure
Interval Versus Continuous Training in Heart Failure
BACKGROUND: The physiopathology of the heart failure involves compensatory mechanisms as exacerbated neurohormonal activity, endothelial dysfunction and consequently the muscle disability and exercise intolerance.
- Trial name
- NCT02448147
- Testing
- Interval training, Continuous training
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Bipolar II Disorder, Most Recent Episode Major Depressive
The Role of iTBS in Bipolar II Depression
There is a paucity of evidence-supported treatment choices for bipolar II depression (BD-II depression), hindered by multiple comorbidity and manic switch. In addition, a slower response also burdens the patients.
- Trial name
- NCT04998097
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Germ Cell Ovarian Cancer, Germ Cell Tumor
SerUm and Plasma MicroRNAs in Malignant Ovarian gERm Cell Tumours
The goal of this observational case-control study is to learn about the circulating and tissue microRNA expression, imaging and radiomic profiles of malignant ovarian germ cell tumours (MOGCT) compared to patients with a benign…
- Conditions
- Germ Cell Ovarian Cancer, Germ Cell Tumor, Germ Cell Cancer, Germ Cell Neoplasia
- Trial name
- SUMMER (NCT06329323)
- Testing
- Blood test, Pathology specimen miRNA expression
- Volunteers
- 24 people
- Sponsor
- Imperial College London
Periodontal Diseases
Effect of Non-chirurgical Periodontal Treatment on the Immune System From a Gender Perspective
The goal of this observational study is to evaluate non-surgical periodontal treatment in women and men with periodontitis with and without obesity.
- Trial name
- NCT06261723
- Testing
- non-chirurgical periodontal treatment
- Where
- 2 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Squamous Cell Carcinoma of the Oropharynx, Carcinomas of Unknown Primary Site
Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus
Based on the evidence summarized in the introduction, the clinician hypothesize that the detection of the presence and expression of HPV-DNA, certain miRNAs, and a certain mutational profile in the tissues and biological fluids…
- Conditions
- Squamous Cell Carcinoma of the Oropharynx, Carcinomas of Unknown Primary Site, High-risk Human Papillomavirus Infection, Liquid Biopsy
- Trial name
- NCT05918510
- Testing
- Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- Regina Elena Cancer Institute
Coronary Artery Disease, Atherosclerosis, Coronary
Latvian Early Atherosclerosis Registry
Atherosclerosis and its complications are a global problem. There are several widely known and proven risk factors that promotes atherogenesis in the majority of patients.
- Trial name
- NCT06393894
- Testing
- Near infrared spectroscopy, Genetic testing for LDLR, APOB, PCSK9 and LDLRAP1 mutations and niR-126, -145 and -155 expression.
- Where
- Latvia
- Volunteers
- 100 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Cancer
The Role of SNP rs2910164 in Patients Treated With Immune Checkpoint Inhibitors
The objective of this study is to investigate whether the SNP rs2910164 in the pre-miR-146a gene is associated with outcome and toxicity of immune checkpoint inhibitor therapy.
- Trial name
- NCT04038996
- Volunteers
- 179 people
- Sponsor
- University of Freiburg
microRNA Profiles
MicroRNA Expression in Everolimus-based Versus Tacrolimus-based Regimens in Kidney Transplantation
The calcineurin inhibitor drugs including cyclosporin and tacrolimus are well-known as nephrotoxicity. However, these drugs are essential for kidney transplant especially in high immunological risks.
- Trial name
- NCT02091973
- Testing
- Everolimus, Tacrolimus
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chulalongkorn University
PDAC - Pancreatic Ductal Adenocarcinoma
Forecasting Occult liveR Metastasis Using an Exosomal Signature for Intelligent Guided Hepatic Targeting
Early liver metastasis (Early-LiM) is the most significant prognostic factor in pancreatic ductal adenocarcinoma (PDAC) and is thought to originate from occult micrometastases present at the time of surgery.
- Trial name
- FORESIGHT (NCT07224802)
- Testing
- EXELiM assay (qRT-PCR validation), EXELiM small RNA sequencing
- Where
- United States
- Volunteers
- 372 people
- Sponsor
- City of Hope Medical Center
Late Onset Pompe Disease, Pompe Disease
Search for Serum/Plasma Biomarkers in Pompe's Disease
This study aims to analyze serum and plasma samples from patients with late onset Pompe disease treated and not treated with enzyme replacement therapy (ERT) to identify microRNA that could be specific of the disease.
- Trial name
- BIOPOMPE (NCT03045042)
- Testing
- Enzyme Replacement Agent
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiovascular Disease, Hypertension
RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2
Background: The Framingham Heart Study (FHS) was initiated by the U.S Public Health Service in 1948 and turned over to the newly established National Heart Institute in 1951.
- Trial name
- NCT03225183
- Where
- United States
- Volunteers
- 1,700 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Heart Failure
Novel Vascular Biomarkers Behaviour and Clinical Value in Heart Failure and CRT
The purpose of this study is to understand the behaviour of certain blood markers in patients with heart failure who undergo a cardiac device implantation procedure called cardiac resynchronization therapy (CRT).
- Trial name
- COVERT-HF (NCT02541773)
- Testing
- Cardiac Resynchronisation Therapy
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Coronary Artery Disease
The Effect of Structured Lifestyle Modification and Yoga Practice on Metabolic Processes Associated With Cardiovascular Disease
The aim of the prospective randomized single center study is to evaluate the effect of a short-term (16 weeks) yoga program on micro RNA (miRNA) expression and cardiovascular disease (CVD) risk factors in patients with CVD.
- Trial name
- SLYM II (NCT05250310)
- Testing
- Chair Yoga
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Neurodegenerative Diseases, Alzheimer's Disease
Functionalized Point of Care and 3D Printed Dental Aligners as Devices for Early Detection of Neurodegenerative Diseases
The treatment of dementias of neurodegenerative origin is currently limited to symptomatic drugs that are unable to interfere with the underlying mechanisms of neurodegeneration, as the pathological processes leading to dementia…
- Trial name
- PREDICTIVE (NCT07870070)
- Where
- Italy
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Rheumatoid Arthritis
Tocilizumab Effect on microRNA Expression and Adipokine Levels in Rheumatoid Arthritis Patients
The investigators propose to identify changes in cytokines like adipocytokines and microRNA (miR) expression (for example miR-9, miR-16, miR-125, miR-132, miR-146a, miR-150, miR-155, miR-181 and miR-223) in peripheral blood…
- Trial name
- NCT03149796
- Testing
- laboratory blood tests
- Volunteers
- 80 people
- Sponsor
- Carmel Medical Center