Clinical trials: MicroRNAs
Asthma
Identification of Plasma miRNAs as Potential Biomarkers in Asthma Exacerbation
We hypothesize that there is a statistically significant difference in miRNA profiling and expression of subjects with asthma upon its exacerbation compared to patient's baseline level or following effective treatment of an…
- Trial name
- NCT01631760
- Testing
- no intervention
- Where
- 2 sites in United States
- Sponsor
- University of South Florida
Skin Cancer
Expression Levels of RISC and Microprocessor Complex Components in Epithelial Skin Cancer
MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation.
- Trial name
- NCT01345760
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Endometrial Cancer
Analysis of miRNA Expression in Endometrial Cancer
The TCGA project identified four distinct prognostic groups of endometrial carcinoma (EC) based on molecular alterations: (i) the ultramutated subtype that encompasses POLE mutated (POLE) cases; (ii) the hypermutated subtype…
- Trial name
- MIRCE (NCT04845425)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Neonatal Seizure, Epilepsy
Evaluating the Role of Inflammation in Neonatal Epileptogenesis
The purpose of this study evaluate the relationship between inflammation and epilepsy in neonates with seizures after birth.
- Conditions
- Neonatal Seizure, Epilepsy, Seizures, Inflammatory Response
- Trial name
- NSR-RISE (NCT04259125)
- Testing
- Blood draw, Survey
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Francisco
Pulmonary Hypertension Due to Left Heart Disease, Pulmonary Hypertension (PH)
Evaluation of the BMPR2-Activin Signaling Pathway in Group II Pulmonary Hypertension.
Previous data from our group showed reduced BMPR2 isoform A in pulmonary hypertension associated with left heart disease (PH-LHD) of valvular origin.
- Conditions
- Pulmonary Hypertension Due to Left Heart Disease, Pulmonary Hypertension (PH), Heart Failure
- Trial name
- BREATHE-PH (NCT07537517)
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Type 2 Diabetes Mellitus
Dapagliflozin, Cardio-Metabolic Risk Factors and Type-2 Diabetes
Dapagliflozin is a member of the sodium-glucose cotransporter-2 (SGLT2) inhibitor class antidiabetes agents which produces significant and sustained reductions in glycemic parameters in patients with type 2 diabetes (T2DM).
- Trial name
- NCT03377335
- Testing
- Dapagliflozin 10mg, Metformin
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- University of Palermo
Bipolar Affective Disorder, Major Depressive Disorder
Exosome for Early Diagnosis of Bipolar Affective Disorder
Objectives: Bipolar disorder (BD) is a chronic and recurrent mental illness characterized by depressive episodes and manic or hypomanic episodes, leading to severe functional impairment and cognitive damage.
- Trial name
- NCT05915312
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Tianjin Anding Hospital
Periodontal Diseases, Inflammation
Effect of Systemic Retinoic Acid Use on Micro Ribonucleic Acid (mRNA) Expression
Ribonucleic acids (RNA) are molecules that transfer genetic information from the nucleus to the cytoplasm for protein translation.
- Trial name
- NCT07142070
- Testing
- Saliva, serum sampling, oral isotretinoin
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medipol University
Breast Cancer
Diagnostic and Prognostic Value of MicroRNA in Breast Cancer Patients
The aim of this study is to evaluate the role of miRNA 125a -5p and miRNA143-3p as a non invasive biomarker in diagnosis of breast cancer and the relationship between MiRNA expression and histopathological features as tumor stage…
- Trial name
- NCT04778202
- Testing
- blood sample collection
- Volunteers
- 50 people
- Sponsor
- Assiut University
Pulmonary Disease, Chronic Obstructive, Pneumonia, Bacterial
Modulation of Steroid Immunosuppression by Alveolar Efferocytosis
The long-term goals of this study are (a) to understand the biological underpinnings for the increased incidence of community-acquired pneumonia in patients with chronic obstructive pulmonary disease (COPD) who are treated with…
- Trial name
- NCT03034642
- Testing
- Bronchoscopy with bilateral bronchoalveolar lavages
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA Ann Arbor Healthcare System
Migraine
Biological Profiles of Neuropeptides, Neurotrophins and miRNA in Migraine
There are still no reliable biomarkers for migraine; the diagnosis is based on symptomatology, and the pathogenesis remains largely a mystery.
- Trial name
- BioM (NCT07832032)
- Testing
- Rimegepant 75 MG
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Nordlandssykehuset HF
Coronary Artery Bypass Graft Triple Vessel
MicroRNA Mediates Volatile Anesthetics Preconditioning Induced Artery Protection
It has been reported that volatile anesthetics preconditioning mediates protection of organ via microRNA. We want to study on the effects of isoflurane preconditioning on expression of microRNA and mRNA in the specimens of…
- Trial name
- NCT02678650
- Testing
- volatile anesthetics(isoflurane), propofol intravenous anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Liang Zhang
Coronary Disease
Expression Profiling of microRNA Following Administration of Dexmedetomidine
The purpose of the study is to find out the differential expression profiling of microRNA before and after adiministration of dexmedetomidine in patients undergoing procedures, and then investigators will do some in vitro studies…
- Trial name
- NCT03213743
- Testing
- Dexmedetomidine Injection
- Where
- China
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Cutaneous Melanoma, Nevi
miRNA Machinery in Melanoma, Melanoma Metastases and Benign Melanocytic Naevi
MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation.
- Trial name
- NCT01444560
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- Ruhr University of Bochum
MicroRNAs, Colorectal Cancer
Serum MicroRNAs as Diagnostic Biomarkers of Colorectal Cancer
evaluation the diagnostic value of certain MicroRNAs as biomarkers of Colorectal cancer by comparing its expression levels in Colorectal cancer patients and normal individuals.
- Conditions
- MicroRNAs, Colorectal Cancer, miR-15b, miR-21
- Trial name
- NCT06738225
- Testing
- certain serum MicroRNA biomarkers (miR-15b and miR-21)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bishoy Shehata
Trauma ICU Patients, Endothelial Injury
Inflammation Severity and miRNA-126 in Trauma
Trauma triggers a complex immune response intended to eliminate danger signals and restore physiological balance. Early post-traumatic inflammation is primarily initiated by damage-associated molecular patterns (DAMPs) and…
- Trial name
- NCT07291908
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Melike Cengiz
Urinary Calculi
Screening and Identification of Human Urate Transporter hURAT1 MicroRNA
This study intends to use in patients with renal tissue and blood samples, screening and identification of renal tissue hURAT1 regulating the expression of micro-RNA, for further study of uric acid stone formation mechanism and…
- Trial name
- NCT01973088
- Volunteers
- 80 people
- Sponsor
- Qian-wei Li
Diabetes Mellitus, Type 2
Diabetes Mellitus and microRNA as Risk Factors for Mild Cognitive Impairment: Impact of Life Style Modification
This is a 2-step study; 1st step was a cross sectional study carried out on 163 consecutive Type 2 Diabetes Mellitus (T2DM) patients employee attending outpatient clinics of the National Research Center (NRC), Egypt.
- Trial name
- NCT04891887
- Testing
- Health education program
- Where
- Egypt
- Volunteers
- 163 people
- Sponsor
- National Research Centre, Egypt
Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight
Study of Grape Consumption in Adaptation to Seasonal Photoperiod
The goal of this randomized clinical trial is to learn whether consuming grapes during their natural season can help the body adapt to the shorter daylight hours of winter.
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Overweight, Obesity & Overweight
- Trial name
- PhotoGrape (NCT07886788)
- Testing
- Freeze-Dried Grape Powder, Plain Low-Fat Yogurt, Mediterranean-Style Dietary Guidance
- Where
- Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Acute Myocardial Infarction
The Acute and Chronic Effects of Remote Ischemic Conditioning on Cardiovascular Function
The investigators are going to examine 270 patients within 48h of STEMI with primary percutaneuous intervention. The investigators utilise either a double -with a 15- min intervening interval-, or a single ischemic stimulus by…
- Trial name
- NCT03984123
- Testing
- Brachial cuff, in order to achieve ischemic stimuli
- Where
- Greece
- Volunteers
- 270 people
- Sponsor
- University of Athens