Clinical trials: MicroRNAs
Hepatitis C
Safety Study of SPC3649 in Healthy Men
A placebo-controlled, double-blind, randomized, single dose, dose escalating trial in healthy men to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SPC3649.
- Trial name
- NCT00688012
- Testing
- SPC3649
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Santaris Pharma A/S
Kidney Transplant Failure and Rejection
MiRNA in Kidney Transplantation: Association With Kidney Graft Function and Disease Process
MicroRNAs (miRNAs) belong to a class of small non-coding RNAs that modulate physiological and pathological processes by post-transcriptional regulation of gene expression mainly via translational inhibition of target messenger…
- Trial name
- NCT04413916
- Testing
- miRNA expression
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Sickle Cell Disease
Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.
The purpose of this study is to evaluate the Safety and Efficacy of DREAM01, a gene therapy for Sickle Cell Disease (SCD). The therapy consists of transplanting autologous CD34+ cells transduced ex vivo with a bifunctional…
- Trial name
- DREPAMIR (NCT07432867)
- Testing
- DREAM01 drug product, anti-inflammatory therapy
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Muscle Function
Muscle in Obesity: Imaging, Function and microRNA
Growing evidence suggests that dynapenic abdominal obesity is associated with a greater risk of falls, functional disability and hospitalisation compared to those with dynapenia, obesity or neither phenotype.
- Trial name
- NCT04300504
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Multiple Sclerosis
Immune Regulation in Multiple Sclerosis: The Effect of Glatiramer Acetate on MicroRNA Expression in Antigen-Presenting Cells
MicroRNAs regulate gene expression. The abnormal expression of microRNAs has been reported in many human diseases. The purpose of this pilot study is to determine if microRNA expression is changed in untreated and glatiramer…
- Trial name
- NCT01993004
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cervical Cancer
microRNA Profile in Early-stage Cervical Cancer
Persistent infections with high-risk subtypes of the human papillomavirus (HPV) are recognized as the etiological factor for developing cervical cancer.
- Trial name
- NCT04087785
- Volunteers
- 44 people
- Sponsor
- National Institute of Cancerología
Gestational Diabetes
miRNA (microRNA) and FGF21 (Fibroblast Growth Factor-21) Profile in First Trimester and Gestational Diabetes Prediction
The goal of this observational study is to compare miRNA and FGF21 in pregnancy with and without GDM (Gestational Diabetes) The main question it aims to answer that miRNA and FGF21 are different between two groups.
- Trial name
- NCT05632055
- Testing
- blood draw
- Where
- Thailand
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Cardiogenic Shock, Cardiac Arrest
Platelet Function and Impella Support
Mechanical circulatory support (MCS) with the Impella microaxial pump in the setting of cardiogenic shock/cardiac arrest (CS/CA) is accompanied by substantial risk of life-threatening complications, including hemolysis…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Mechanical Circulatory Support
- Trial name
- IMPELLA-PLT (NCT06487091)
- Testing
- Analysis of platelet function
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Università Vita-Salute San Raffaele
Breast Cancer
MIRNA Profiling of Breast Cancer in Patients Undergoing Neoadjuvant or Adjuvant Treatment for Locally Advanced & Inflammatory Breast Cancer
MicroRNAs (MiRNAs) regulate the translation of RNAs and are implicated in cell proliferation and renewal both under physiologically normal as well as in malignant conditions.
- Trial name
- NCT01231386
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- City of Hope Medical Center
Glioma
Gene Expression, Immunological Status and Metabolome in Glioma Patients
Study on glioma patients treated with brain surgery is focusing on the analysis of their transcriptome expression profile measured in two immune cell populations, CD4+ T cells and CD56+ NK cells.
- Trial name
- NCT01525459
- Testing
- Glioma resection, Blood sampling
- Where
- 3 sites in Slovenia
- Volunteers
- 16 people
- Sponsor
- National Institute of Biology, Slovenia
TBI (Traumatic Brain Injury), Brain Concussion
Dual-Task Exercise for Mild Traumatic Brain Injury (mTBI)
The investigators previously developed a virtual 14-day dual-task walking exercise program and tested its feasibility with individuals with mild traumatic brain injury (mTBI) history.
- Conditions
- TBI (Traumatic Brain Injury), Brain Concussion, Clinical Trial, Rehabilitation
- Trial name
- NCT06037603
- Testing
- Brain & Walk Exercise Every Day (BraW-Day)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Cardiovascular Diseases, Periodontal Diseases
Role of miRNAs in CVD and Periodontitis
Several micro-RNA plays a key role in endothelial function and may be a link for the known interaction of periodontitis and cardiovascular disease.
- Trial name
- NCT05383794
- Testing
- Observation of Evaluation of gingival crevicular fluid miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 200b-3p, miRNA 200b-5p, miRNA 100-5p, miRNA 125-5p levels.
- Where
- Italy
- Volunteers
- 115 people
- Sponsor
- University of Catania
Prostatic Hyperplasia, Urinary Bladder Neck Obstruction
The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction
Urgency, frequency and incomplete emptying are the key symptoms of lower urinary tract dysfunction, including bladder pain syndrome/interstitial cystitis, and overactive bladder syndrome.
- Conditions
- Prostatic Hyperplasia, Urinary Bladder Neck Obstruction, Cystitis, Interstitial
- Trial name
- NCT01482676
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cachexia
Early Diagnosis of Gastric Cancer Cachexia
Gastric cancer is one of the most common malignancies, the morbidity and mortality of which are among the highest. In cancer patients, the incidence of cachexia is very high, and even 80% of patients will eventually develop into…
- Trial name
- NCT06277986
- Testing
- cachexia
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xijing Hospital
T Lymphocyte Disorder
MiRNAs Evaluating Lymphocyte Proliferation and Apoptosis as Well as Prognosis of Sepsis
Sepsis is a systemic inflammatory reaction caused by infection, trauma, etc. In the process of sepsis, the apoptosis of lymphocyte serves as a vital factor of immune dysfunction.
- Trial name
- NCT02756559
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lixin Xie
Breast Carcinoma
Circulating microRNA 21 Expression Level Before and After Neoadjuvant Systemic Therapy in Breast Carcinoma
MicroRNAs (miRNAs) are involved in the development and progression of malignant tumors. In breast cancer, differential miRNA expression has been demonstrated across breast cancer subtypes, with both tumor-promoting and tumor…
- Trial name
- NCT05151224
- Testing
- microRNA 21
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Cancer, Lung, Colon Neoplasm
Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients
This study aims to find out whether certain molecules in the blood, called microRNAs, are linked to how often and how severely people develop nerve damage from chemotherapy.
- Conditions
- Cancer, Lung, Colon Neoplasm, Neuropathy;Peripheral
- Trial name
- miR-CIPN#1 (NCT07427537)
- Testing
- Assessment of blood concentrations of microRNAs, Chemotherapy-induced peripheral neuropathy (CIPN) - grade, Pain assessement
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Prostate Cancer, Radical Prostatectomy
Micro-RNA Expression Profiles in Localised Prostate Cancer
Recurrence free survival The patients will be followed in regular time intervals in accordance with the EAU-Guidelines (2010) and the S-3 Guideline for Prostate cancer of the German Urological Association.
- Trial name
- NCT03338712
- Sponsor
- Wuerzburg University Hospital
Inflammatory Response
Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB
Cardiac surgery has evolved considerably after the advent of cardiopulmonary bypass (CPB), a feature that allowed more precision and tranquility to the heart surgeon.
- Trial name
- NCT02672345
- Testing
- Sevoflurane
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Melanoma
MicroRNA Expression and Function in Cutaneous Malignant Melanoma
Spectrophotometric intracutaneous analysis (SIAscopy) is a new technique for imaging pigmented skin lesions and for diagnosing melanoma and non-melanoma skin cancer.
- Trial name
- NCT00536029
- Where
- Denmark
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet