Clinical trials: MicroRNAs
Multiple Sclerosis, miRNA
miRNA Biomarkers in Multiple Sclerosis
Multiple Sclerosis (MS) characterized by demyelination and axonal degeneration is a chronic inflammatory disease of the central nervous system (CNS).
- Conditions
- Multiple Sclerosis, miRNA, Epigenetic, Biomarker
- Trial name
- NCT04772495
- Testing
- miRNA
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Germ Cell Tumor, Metachronous Malignant Neoplasm
A Study of miRNA 371 in Patients With Germ Cell Tumors
This trial studies whether the blood marker micro ribonucleic acid (miRNA) 371 can predict the chance of cancer returning in patients with germ cell cancers.
- Conditions
- Germ Cell Tumor, Metachronous Malignant Neoplasm, Seminoma, Stage I Testicular Cancer AJCC v8
- Trial name
- NCT04435756
- Testing
- Biomarker Analysis, Blood Product Collection
- Where
- 424 sites in United States, Canada and 1 more
- Volunteers
- 956 people
- Sponsor
- SWOG Cancer Research Network
Breast Cancer
Prospective Observational Study of Antitumor Activity Correlation Between Hormonal Therapy and Expression miRNA100
Mono-centric, observational, prospective study, designed for pts with diagnosis of hormone-positive breast cancer to evaluate the correlation between the response to hormonal treatment indicated by the reduction of the level of…
- Trial name
- BC-P1-2013 (NCT02950207)
- Testing
- miRNA
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Infertility, Male
Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility
Men are recruited to collect seminal plasma samples and serum samples from men with azoospermia, men receiving medical treatment of infertility and men attending semen analysis.
- Trial name
- SemiFluid (NCT02932865)
- Where
- Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Critical Limb Ischemia
miRNAs in Critical Limb Ischemia (miRNACLI)
For the present study, 40 patients affected by critical limb ischemia of different severity will be enrolled: patients affected by critical limb ischemia undergoing subgenual femoropopliteal bypass; patients suffering from…
- Trial name
- miRNACLI (NCT06066268)
- Testing
- Critical limb ischemia: analysis of RNAs, Controls: analysis of RNAs
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS Policlinico S. Donato
Chronic Kidney Disease Requiring Chronic Dialysis
Intradialytic Resistance Training in Haemodialysis Patients
The study will investigate the effects of an intradialytic resistance training on miRNA´s expression and muscle strength in haemodialysis patients.
- Trial name
- IRTHEP (NCT03511924)
- Testing
- Intradialytic resistance training
- Where
- Slovakia
- Volunteers
- 90 people
- Sponsor
- Pavol Jozef Safarik University
Squamous Cell Carcinoma of the Oropharynx, Carcinomas of Unknown Primary Site
Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus
Based on the evidence summarized in the introduction, the clinician hypothesize that the detection of the presence and expression of HPV-DNA, certain miRNAs, and a certain mutational profile in the tissues and biological fluids…
- Conditions
- Squamous Cell Carcinoma of the Oropharynx, Carcinomas of Unknown Primary Site, High-risk Human Papillomavirus Infection, Liquid Biopsy
- Trial name
- NCT05918510
- Testing
- Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- Regina Elena Cancer Institute
Adenocarcinoma - Gastroesophageal Junction (GEJ), Gastric Adenocarcinoma
Sequential FDG-PET and miRNA as Biomarkers of Preoperative Treatment Strategy in LA Oesophago-Gastric Cancer
GastroPET is a prospective, multicenter, non-randomized interventional study evaluating sequential FDG-PET as an early biomarker to guide preoperative treatment in patients with locally advanced resectable oesophago-gastric…
- Conditions
- Adenocarcinoma - Gastroesophageal Junction (GEJ), Gastric Adenocarcinoma, Gastroesophageal Junction (GEJ) Adenocarcinoma
- Trial name
- GastroPET (NCT07791329)
- Testing
- FDG-PET
- Where
- Czechia
- Volunteers
- 144 people
- Sponsor
- Masaryk Memorial Cancer Institute
Rh Disease
Circulating microRNAs as Novel Prognosis Biomarkers for Rheumatoid Arthritis
The correlation of circulating serum miR-125ba and miR-146a expression and clinical response to green tea therapy were analysed in RA patients.Clinical response to green tea therapy for 24 weeks was calculated from DAS28 scores.
- Trial name
- NCT03719469
- Testing
- Green tea group
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- King Saud University
Asthma, COPD
Circulating Micro RNAs Expression in Egyptian Bronchial Asthma and COPD Patients
This cross sectional study will be carried out on 30 subjects who will be recruited from the outpatient clinic of Chest Department, Tanta University Hospital.
- Trial name
- NCT02719145
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Type1diabetes
The Relationship of RAGE Gene Polymorphism With Type I Diabetes in Egyptian Patients
Type I Diabetes Mellitus (TIDM) is a chronic metabolic disorder caused by the immune-mediated T-cell and macrophages that typically affects insulin-producing β-cells of Langerhans leading to cell destruction and absolute insulin…
- Trial name
- NCT05874323
- Testing
- Detection of RAGE gene polymorphism (rs1800625)
- Where
- Egypt
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Ovarian Aging, In Vitro Fertilisation (IVF) Treatment
Follicular Fluid microRNAs in Ovarian Aging and Reproduction
The purpose of this study is to investigate the role of exosomal microRNAs (miRNAs) in follicular fluid (FF) as biomarkers of ovarian aging and predictors of in vitro fertilization (IVF) outcomes.
- Conditions
- Ovarian Aging, In Vitro Fertilisation (IVF) Treatment, InVitro Fertilization, In Vitro Fertilization Outcome
- Trial name
- NCT07214246
- Testing
- No Interventions
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Central Florida
Cardiovascular Disease, Hypertension
RNA Sequencing in the Framingham Heart Study Third Generation Cohort Exam 2
Background: The Framingham Heart Study (FHS) was initiated by the U.S Public Health Service in 1948 and turned over to the newly established National Heart Institute in 1951.
- Trial name
- NCT03225183
- Where
- United States
- Volunteers
- 1,700 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiopulmonary Bypass, Ischemic Postconditioning
Effects of Ischemic Postconditioning on MicroRNAs in Double Valve Replacement
1. Cardiopulmonary bypass and cardioplegic arrest could regulate expression of microRNAs in patients undergoing double valve replacement (aortic and mitral). 2.
- Trial name
- NCT01804283
- Testing
- ischemic postconditioning, double valve replacement, heart-lung machine
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Central South University
Autism Spectrum Disorder, Developmental Delay
Validation of a Salivary miRNA Diagnostic Test for ASD
This study involves sample collection to identify biomarkers relating to Autism Spectrum Disorder(ASD) in the saliva of children who are between the ages of 18 months to 6 years and 11 months.
- Trial name
- NCT05418023
- Testing
- Salivary Collection, Adaptive Assessment, Medical and Demographic questionnaire
- Where
- 16 sites in United States
- Volunteers
- 6,604 people
- Sponsor
- Quadrant Biosciences Inc.
Periodontal Diseases
Effect of Non-chirurgical Periodontal Treatment on the Immune System From a Gender Perspective
The goal of this observational study is to evaluate non-surgical periodontal treatment in women and men with periodontitis with and without obesity.
- Trial name
- NCT06261723
- Testing
- non-chirurgical periodontal treatment
- Where
- 2 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
HFrEF - Heart Failure With Reduced Ejection Fraction, Cardiac Rehabilitation
Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction
Exercise intolerance, measured as peak oxygen consumption (VO₂peak) during exercise in patients with heart failure with reduced ejection fraction (HFrEF).
- Conditions
- HFrEF - Heart Failure With Reduced Ejection Fraction, Cardiac Rehabilitation, Exercise Training, Exercise Adaptations
- Trial name
- PrédicRéa (NCT07164911)
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier de Corbie
Lung Cancer
Addition of microRNA Blood Test to Lung Cancer Screening Low Dose CT
To demonstrate that the specificity of the Hummingbird microRNA profile for the diagnosis of lung cancer in a cohort of patients who meet current eligibility criteria for lung cancer screening in the U.S.
- Trial name
- NCT03452514
- Where
- 4 sites in United States
- Volunteers
- 479 people
- Sponsor
- Hummingbird Diagnostics
Erectile Dysfunction
Differential Plasma MicroRNA Profiles in ED and Normal Erectile Function in Older Males
Erectile dysfunction (ED) is strongly associated with aging. With the rapidly expanding aging population and the increase in life expectancy, an increase in the prevalence of ED is expected in the years to come.
- Trial name
- NCT01830049
- Testing
- Take blood
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Pulmonary Hypertension
The Role of miRNA in Group 3 Pulmonary Hypertension
This study recognizes the substantial value of lung tissue obtained from explanted lungs for fundamental research purposes.By analyzing pulmonary tissue affected by pulmonary hypertension, it is possible to discover shared…
- Trial name
- miRNA-GR3PH (NCT06714136)
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna