Clinical trials: MicroRNAs
Cirrhosis, Acute Decompensation
Study of microRNAs in a Decompensated Cirrhosis
Cirrhotic patients are at higher risk of sepsis due to impaired innate and adaptive immune responses. Septic complications represent a major issue in the management of cirrhotic patients, with a 1-month mortality rate of 23%…
- Trial name
- EmiC (NCT03905746)
- Testing
- blood sample at Day 0, blood sample at Day 2 and Day 7, stool sample at Day 0
- Where
- France
- Volunteers
- 444 people
- Sponsor
- Hospices Civils de Lyon
Acute GVH Disease
MicroRNAs as Diagnostic and Predictive Biomarkers for Acute Graft Versus Host Disease
The goal of this research proposal is to identify a miRNA expression profile as a biomarker to diagnose and predict acute graft versus host disease (aGVHD) in patients who undergo allogeneic transplantation.
- Trial name
- NCT02917148
- Testing
- Peripheral Venipuncture or Blood draw from Central Line
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Periodontitis
Diagnostic Potential of the Salivary Biomarkers to Differentiate Statuses of Periodontitis
Periodontitis is a chronic inflammatory disease characterized by both dysbiosis of oral microbiota and proinflammatory events involving both cells and mediators from innate and adaptive immunity.
- Trial name
- NCT05722613
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Cardiac Arrest
Circulating Biomarkers Predict Neurological Outcome After Cardiac Arrest
Prediction of clinical outcome after cardiac arrest is clinically important.Early prognostication after successful cardiopulmonary resuscitation is difficult, and there is a need for novel methods to estimate the extent of brain…
- Trial name
- CABNO (NCT02297776)
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai 10th People's Hospital
MicroRNA in Endometrial Fluid
Transciptomic Modification Induced by miRNAs in Endometrial Fluid
The purpose of this study is to understand the mechanism of communication between the uterine environment and the preimplantation human embryo.
- Trial name
- miRNA_EF (NCT02554539)
- Testing
- Endometrial fluid aspiration
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Colon Cancer
An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer
Recent studies have highlighted the potential benefits of neoadjuvant chemotherapy (NAC) in colon cancer; however, its indication is generally limited to cases corresponding to pathological stage IIB or higher.
- Trial name
- EXPOSE (NCT07255729)
- Testing
- Diagnostic Test: EXPOSE assay（Small RNA-seq of exosomal miRNAs）, Diagnostic Test: EXPOSE RT-qPCR panel
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- City of Hope Medical Center
Colorectal Cancer
Pomegranate Extract Supplementation in Colorectal Cancer Patients
The most relevant pomegranate phenolics (ellagitannins and ellagic acid) are extensively metabolized by the human gut microbiota to yield a number of metabolites called urolithins (mainly Uro-A).
- Trial name
- POMEcolon (NCT01916239)
- Testing
- Standard pomegranate extract formulation, Pomegranate extract formulation-1, Pomegranate extract formulation-2
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- National Research Council, Spain
Adolescent Idiopathic Scoliosis
Identification of Circulating microRNAs in Adolescent Idiopathic Scoliosis
The aim of the present study is to evaluate the expression of a large panel of microRNAs, already known and validated in other ortopedic pathologies and bone metabolism, in the plasma of Adolescent Idiopathic Scoliosis (AIS)…
- Trial name
- IMIRSA (NCT04746586)
- Testing
- Circulating MiRNA indentification
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
MIRAS, Testicular Abnominalies
Could miRNAs be Used as Markers for Distinguishing Undescended Testicles From Retractile Testicles
Background: Undescended testicles (UDTs) are common in male infants. Untreated UDT poses risks such as infertility (IF), testicular cancer (TC), and testicular torsion (TT).
- Conditions
- MIRAS, Testicular Abnominalies, Undescended Testes
- Trial name
- miRNA (NCT07315737)
- Testing
- miRNA
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Dr. Mevlüt Keleş
Inflammatory Bowel Disease
Micro Ribonucleic Acid (RNA) as Cholinergic Tone and Inflammatory Regulator in Inflammatory Bowel Disease
There is a reciprocal relationship between the central nervous system and the immune system. Stimulation of the vagus nerve results in secretion of acetylcholine (Ach) which decreases secretion of pro-inflammatory cytokines.
- Trial name
- NCT00734331
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Healthy Volunteer
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MRG-110 Following Intradermal Injection in Healthy Volunteers
MRG-110 is intended to promote the growth of new blood vessels by inhibiting a molecule called miR-92a. MRG-110 is being studied to determine if it can accelerate healing of wounds by improving blood flow into the wound area.
- Trial name
- NCT03603431
- Testing
- MRG-110
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- miRagen Therapeutics, Inc.
Chronic Kidney Disease Requiring Hemodialysis, Chronic Kidney Disease
Serum circ_DLGAP4, lncRNA KCNQ1OT1, and Their Targets by Erythropoietin Resistance in Chronic Kidney Disease
Non-coding RNAs have evolved as biomarkers and as phased and specific therapeutic targets for chronic kidney disease (CKD). However, their clinical significance in CKD patients is largely unexplored.
- Trial name
- NCT07037953
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Idiopathic Urticaria
Three-month, Single-center Study to Identify Biomarkers/Response to Xolair Therapy in Chronic Idiopathic Urticaria
This is a single center, non-comparative exploratory study, to investigate the effect of omalizumab over a 3-month treatment period in adult (≥18 years) patients with chronic idiopathic urticaria who had remained symptomatic…
- Trial name
- NCT02814630
- Testing
- Xolair
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Asthma Inc Clinical Research Center
Heart Failure
Effect of Levosimendan on miRNAs Regulation in the Failing Hearts
Chronic heart failure is the terminal stage of various cardiovascular diseases. It is characterized with high fatality rate and high recurrence rate, which brings a heavy economic burden to patients and society.
- Trial name
- NCT04950569
- Testing
- levosimendan
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Tongji Hospital
microRNA Profiles
MicroRNA Expression in Everolimus-based Versus Tacrolimus-based Regimens in Kidney Transplantation
The calcineurin inhibitor drugs including cyclosporin and tacrolimus are well-known as nephrotoxicity. However, these drugs are essential for kidney transplant especially in high immunological risks.
- Trial name
- NCT02091973
- Testing
- Everolimus, Tacrolimus
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Chulalongkorn University
Testis Cancer
miRNA to Guide Appropriate Intervention of Small Testis Masses
This study aims to determine, for the first time, if miRNA-371a-3p can be used as an accurate biomarker to identify which small (≤ 2cm) testicular masses are malignant and aid in clinical decision-making to offer surgery or…
- Trial name
- miRSTM (NCT07852871)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Sepsis, Acute Kidney Injury
miRNA in Septic Acute Kidney Injury
Acute kidney injury is a common and serious complication of sepsis and septic shock, which may be associated with a worse outcome of the patient's condition.
- Conditions
- Sepsis, Acute Kidney Injury, Acute Kidney Injury Due to Sepsis
- Trial name
- NCT06498336
- Testing
- Laboratory examination to determine the presence of sepsis, Laboratory examination to determine the presence of sepsis and acute kidney injury, Laboratory examination to determine miRNA and biochemical parameters
- Where
- 2 sites in Czechia
- Volunteers
- 211 people
- Sponsor
- University Hospital Ostrava
HIV Infection, Tuberculosis Infection
Micro RNA as Prediction and/or Prognostic Markers of IRIS in TB-HIV Co-infected Patients
The role of miRNAs in HIV disease is yet to be completely defined. Host miRNAs target certain HIV genes, thus can affect HIV replication and participate in viral control.
- Trial name
- miRNA (NCT03941210)
- Testing
- Detection of molecular Biomarkers
- Where
- Cambodia
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Atherosclerosis, Neointima
Effect of Low-dose vs. High-dose Pitavastatin on In-stent Restenosis
To compare low dose (1mg) pitavastatin and high dose (4mg) pitavastatin on neointimal hyperplasia and atherosclerosis progression by using optical coherence tomography (OCT) and near-infrared spectroscopy (NIRS) at 12 months…
- Conditions
- Atherosclerosis, Neointima, Angina
- Trial name
- ELEVATE (NCT02545231)
- Testing
- Pitavastatin 1mg, Pitavastatin 4mg
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Korea University Anam Hospital
Anterior Myocardial Infarction
Effects of Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) Therapy on miRNAs Expression and Absolute Microvascular Resistance by Continuous Thermodilution in ST-segment Elevation Myocardial Infarction (STEMI) Patients: PiCSO-STEMI TRIAL
In this study we pretend to determine the molecular (miRNAs expression, angiogenic and inflammatory biomarkers) and microcirculatory (assessed by the innovative continuous intracoronary thermodilution technique) effects of PiCSO…
- Trial name
- PiCSO-STEMI (NCT05644925)
- Testing
- PiCSO Impulse System, Percutaneous Coronary Intervention (PCI)
- Sponsor
- Fundacio Privada Mon Clinic Barcelona