Clinical trials: MicroRNAs
Vascular Aneurysm
miRNA in Patients With Thoracic, Abdominal and Intracranial Aneurysms
To assess the expression of miRNA in patients with TAA, AAA in aneurysmatic tissue and to compare this expression with the healthy tissue in the same patient.
- Trial name
- miRNA (NCT05382611)
- Testing
- ngs next generation sequencing
- Where
- Czechia
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Na Homolce Hospital
Kidney Transplant Failure and Rejection
MiRNA in Kidney Transplantation: Association With Kidney Graft Function and Disease Process
MicroRNAs (miRNAs) belong to a class of small non-coding RNAs that modulate physiological and pathological processes by post-transcriptional regulation of gene expression mainly via translational inhibition of target messenger…
- Trial name
- NCT04413916
- Testing
- miRNA expression
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Rectal Cancer
Timisnar - Biomarkers Substudy (Timisnar-mirna)
Neoadjuvant chemoradiotherapy (nCHT) followed by surgery is the mainstay treatment for locally advanced rectal cancer, leading to significant decrease in tumor size (downsizing) and a shift towards earlier disease stage in the…
- Trial name
- TiMiSNAR-miRNA (NCT03962088)
- Testing
- miRNA
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Cardiogenic Shock, Cardiac Arrest
Platelet Function and Impella Support
Mechanical circulatory support (MCS) with the Impella microaxial pump in the setting of cardiogenic shock/cardiac arrest (CS/CA) is accompanied by substantial risk of life-threatening complications, including hemolysis…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Mechanical Circulatory Support
- Trial name
- IMPELLA-PLT (NCT06487091)
- Testing
- Analysis of platelet function
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Università Vita-Salute San Raffaele
Head and Neck Squamous Cell Carcinoma
Expression & Epigenetic Silencing of MicroRNA for Predicting Therapeutic Response and Prognosis of HPV-negative HNSCC
A two-part molecular epidemiological study will be conducted to comprehensively assess the association between miR expression and miR promoter methylation and the response to therapy and prognosis in primary, HPV-negative HNSCC…
- Trial name
- NCT03953443
- Testing
- Not interventional
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New Mexico Cancer Research Alliance
Coronary Disease
Expression Profiling of microRNA Following Administration of Dexmedetomidine
The purpose of the study is to find out the differential expression profiling of microRNA before and after adiministration of dexmedetomidine in patients undergoing procedures, and then investigators will do some in vitro studies…
- Trial name
- NCT03213743
- Testing
- Dexmedetomidine Injection
- Where
- China
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Breast Cancer Invasive Nos
A Combined GWAS and miRNA for the Identification of Bevacizumab Response Predictors in Metastatic Breast Cancer
GEI-BEV-2011-01 is an Observational multicenter study. The study, involving 200 (100 non-responders and 100 best responders) metastatic breast cancer patients, will search for specific genetic variants (SNPs) and miRNA signatures…
- Trial name
- NCT01598285
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Spanish Breast Cancer Research Group
Drug Resistant Epilepsy
Circulating microRNAs as Biomarkers of RESPIratory Dysfunction in Patients With Refractory epilePSY
Sudden and unexpected death in epilepsy (SUDEP) has become a major issue for patients with epilepsy and their physicians. SUDEP is a nontraumatic and non-drowning death in patients with epilepsy, unrelated to a documented status…
- Trial name
- MIRESPILEPSY (NCT03419000)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Autism Spectrum Disorder, Developmental Delay
Improving Autism Screening With Brain-Related miRNA
The goal of this project is to identify specific miRNAs that are increased or decreased in the saliva of children with developmental delay and are useful for screening toddlers for ASD.
- Trial name
- NCT02712853
- Testing
- Saliva collection, Vineland Adaptive Behavior Scale-II Assessment
- Where
- United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Gastric Cancer
Detection of Minimal Residual Disease Using Exosomal miRNA Distant Metastasis Markers
Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Even in patients undergoing curative surgery for non-metastatic disease, postoperative recurrence frequently occurs due to undetected minimal residual…
- Trial name
- DESTINEX-REM (NCT07243015)
- Testing
- small RNA-seq or array, ENLIGHT Assay
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- City of Hope Medical Center
Drug-Induced Liver Injury, Liver Failure
Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without liver injuries 2.
- Trial name
- NCT03000621
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer
Gastrointestinal (GI) cancers remain a major global health burden, largely due to the lack of effective and accessible early screening strategies.
- Conditions
- Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma (PDAC), Esophageal Squamous Cell Carcinoma (ESCC)
- Trial name
- MiGIC (NCT07224750)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Preeclampsia, Chronic Periodontitis
microRNA 155 Levels and Periodontal Microflora (Bacteria and Virus) in Preeclampsia.
Preeclamptic women with and without chronic periodontitis were recruited for the study. Subgingival plaque samples and placental tissue samples(postpartum) were obtained from the participants for the microbial analysis(bacteria…
- Trial name
- NCT04277390
- Testing
- clinical intervention for microbial analysis and MIR155 as biomarker
- Where
- India
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Liver Diseases
Early Detection of Hepatocellular Carcinoma in a High-risk Prospective Cohort (ELEGANCE)
Hepatocellular carcinoma (HCC) is the 7th most common cause of cancer death globally but only 20% are diagnosed in its early stages where cure is possible.
- Trial name
- NCT04965259
- Where
- 14 sites in Singapore
- Volunteers
- 2,002 people
- Sponsor
- National Cancer Centre, Singapore
HCV Infection ( Genotype 4)
Impact of IL-28B rs12979860 and rs4803217 Gene Polymorphisms Associated With miRNAs Deregulation on HCV-related Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide as well as in Egypt. Despite improvements in HCC therapy, the prognosis for HCC patients remains poor.
- Trial name
- NCT02507882
- Testing
- IL28B Polymorphism, miRNA quantification
- Where
- Egypt
- Volunteers
- 405 people
- Sponsor
- Dr.Waleed Samir
Postmenopausal Osteoporosis
Study on the microRNA Expression Level in Postmenopausal Osteoporosis
The miRNA plays an important regulation role in gene expression, and also closely related to bone metabolism. Previous research found that postmenopausal osteoporosis with kidney Yin deficiency syndrome (POP) is associated with…
- Trial name
- microRNA (NCT02128009)
- Testing
- osteoporosis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fujian Academy of Traditional Chinese Medicine
STEMI - ST Elevation Myocardial Infarction, Thrombi
Pan-Cardio-Genetics Clot Assessment in Acute Coronary Syndromes
Acute myocardial infarction with ST elevation (STEMI) is one of the leading causes of mortality. Although the presence of thrombus in STEMI patients has been linked to adverse outcomes, routine thrombus aspiration has not been…
- Conditions
- STEMI - ST Elevation Myocardial Infarction, Thrombi, MicroRNA
- Trial name
- PGCA-ACS (NCT03832153)
- Testing
- thrombus aspiration
- Where
- Greece
- Sponsor
- Aristotle University Of Thessaloniki
Childhood Chronic Kidney Disease
Cardiovascular Comorbidity in Children With Chronic Kidney Disease
This 3-year study will systematically evaluate the prevalence, clinical symptoms, and progression of CV and kidney disease and assess the impact of potential genetic, pharmacological, behavior, and environmental risk factors in a…
- Trial name
- NCT03227055
- Where
- Taiwan
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Squamous Cell Carcinoma of the Oropharynx, Carcinomas of Unknown Primary Site
Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus
Based on the evidence summarized in the introduction, the clinician hypothesize that the detection of the presence and expression of HPV-DNA, certain miRNAs, and a certain mutational profile in the tissues and biological fluids…
- Conditions
- Squamous Cell Carcinoma of the Oropharynx, Carcinomas of Unknown Primary Site, High-risk Human Papillomavirus Infection, Liquid Biopsy
- Trial name
- NCT05918510
- Testing
- Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- Regina Elena Cancer Institute
Uveal Melanoma
The Role of Genetic Mutations and of Circulating mRNAs in Uveal Melanoma
The aim of the study is to identify genetic and epigenetic biomarkers in uveal melanoma, and to evaluate their diagnostic and prognostic role. In particular, the specific objectives are: 1.
- Trial name
- NCT05179174
- Testing
- blood sample examination
- Where
- 3 sites in Italy, Poland
- Volunteers
- 102 people
- Sponsor
- University of Catania