Clinical trials: MicroRNAs
H. Pylori Infection, Carcinogenesis
Study on the Probiotics Regulating miRNA in H. Pylori-induced Wnt/β-catenin Gastric Carcinogenesis.
Background. H. pylori has recognized as a type 1 carcinogen for gastric adenocarcinoma. Although H. pylori eradication promises to reduce the risk of gastric cancer, the regression rate of intestinal metaplasia (IM) after…
- Trial name
- NCT05544396
- Testing
- probiotic
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Cheng-Kung University Hospital
Chronic Periodontitis, Coronary Artery Disease
Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease
The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further.
- Conditions
- Chronic Periodontitis, Coronary Artery Disease, miRNA
- Trial name
- NCT04583085
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Glioma
Three miRNA Signatures in Glioma: From Molecular Mechanisms to Potential Clinical Application
Individual overexpression of the three miRNAs negatively affects cell viability and proliferation mainly in grade III IDH-wild type cells, while in higher grade cells, the effect is more pronounced when the entire signature is…
- Trial name
- NCT06883214
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Regina Elena Cancer Institute
Allergic Contact Dermatitis
MicroRNA-126 and Its Target VCAM-1Dermatitis to Nickel
Background. Allergic Contact Dermatitis (ACD) is an inflammatory skin disease mediated by direct contact with allergens as nickel, the most common allergen, that may be related with epigenetic changes. Objective.
- Trial name
- NCT04365140
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Universidad Autonoma de San Luis Potosí
Primary Immune Thrombocytopenia
Plasma microRNA Levels and Some Cytokines Expression in Patients With ITP Primary Immune Thrombocytopenic Purpura (ITP)
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by low platelet counts with or without mucocutaneous bleeding (McMillan, 2007).
- Trial name
- microRNAITP (NCT05371743)
- Testing
- Plasma RNA isolation, qPCR analysis of micro RNA, estimation of serum level of IL2, estimation of serum level of IL17
- Where
- Egypt
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Sohag University
Bipolar Disorder, Frontotemporal Dementia, Behavioral Variant
A Study of the Behavioral Variant of Frontotemporal Dementia and Bipolar Disorder: a Neuroimaging and Epigenetics Integrated Approach
The aim of this study is to investigate the selective epigenetic modifications and their effect on brain's morphology and functionality in the frontotemporal dementia behavioral variant and bipolar disorder.
- Trial name
- DISBAND (NCT06706687)
- Testing
- DISBAND protocol
- Where
- Italy
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Aortic Aneurysm
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study "Micro AAA"
The objective of this study is to establish whether patients with aortic aneurysm, compared to general population, have higher levels of selected miRNAs and whether there is significant association between the level of miRNA in…
- Trial name
- NCT03090763
- Testing
- PCR and sequencing
- Where
- Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Breast Cancer
An In-situ Detection for MicroRNA
We designed a new in-site detection method for MicroRNA in the serum of patients with breast cancer.
- Trial name
- NCT06529614
- Testing
- In-situ detection for Micro-RNA
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Exercise Training, Microgreens
Microgreens and miRNAs
In this study, we investigated the impact of a comprehensive microgreen and wheatgrass juice protocol on the miRNA response following a standardized EIMD model and whether microgreen consumption could modulate key miRNA markers…
- Conditions
- Exercise Training, Microgreens, miRNAs
- Trial name
- GreenmiRNAs (NCT07540858)
- Testing
- Microgreens, not received any supplement
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Heart Transplanted Patients, Lung Transplanted Patients
Unraveling Mechanism of Action of Extracorporeal Photopheresis in Heart and Lung Transplant Patients
This is a prospective observational single center national study. Lung and heart transplant patients with a definite diagnosis of chronic lung allograft dysfunction (CLAD) or cardiac allograft vasculopathy (CAV) will be assigned…
- Conditions
- Heart Transplanted Patients, Lung Transplanted Patients, Chronic Lung Allograft Dysfunction (CLAD), Cardiac Allograft Vasculopathy
- Trial name
- URRAH (NCT06899828)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Lynch Syndrome, Lynch Syndrome I
Lynch Syndrome X-Talk of Enteral Mucosa With Immune System
Lynch syndrome (OMIM #120435) is the most common dominantly inherited colorectal cancer syndrome with an estimated prevalence of 1:270 individuals.
- Conditions
- Lynch Syndrome, Lynch Syndrome I, Lynch Syndrome II, Lynch Syndrome I (Site-specific Colonic Cancer)
- Trial name
- LYNX-EYE (NCT06708429)
- Testing
- LYNX EYE (Lynch syndrome X-Talk of Enteral mucosa with Immune System)
- Where
- 5 sites in United States, Italy
- Volunteers
- 300 people
- Sponsor
- San Raffaele University
Glioma, Neurofibromatosis Type 1
MicroRNAs in Patients With Neurofibromatosis Type 1
MicroRNAs are small molecules which have recently been discovered in cells. They are known to be responsible for the normal development of cells and when they are disrupted can contribute to the development of cancer.
- Trial name
- NCT01595139
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Obstructive Sleep Apnea
Extracellular microRNA: Biomarkers of Endothelial Dysfunction in Obese Adolescents & Adults With Obstructive Sleep Apnea
Using a prospective observational approach and a clinical trial design comparing the effectiveness of continuous positive airway pressure to diet and exercise, investigators plan to evaluate how obstructive sleep apnea (OSA)…
- Trial name
- NCT03546751
- Testing
- Continuous Positive Airway Pressure, Diet And Exercise
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cluster Headache
Role of Specific microRNAs in Cluster Headache
Cluster headache (CH) is a primary headache included in the trigeminal autonomic cephalalgias (TACs) according to the International Calssification of Headache Disorder, Third Edition.
- Trial name
- 5*1000 (NCT06503328)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Periodontitis, Adult
GCF miRNA-223 , -214 Levels in Smokers and Nonsmokers Periodontitis Patients
Objective: Periodontitis is a multifactorial disease that affects a wide range of populations. However, its pathogenesis remains unclear. miRNAs are now considered potential diagnostic markers for many inflammatory diseases.
- Trial name
- NCT06064799
- Testing
- miRNA-223 & -214 detection
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Fayoum University
PreDiabetes
Precision Medicine for Preventing Type 2 Diabetes: a Step Forward
The prevalence of type 2 diabetes (T2D) has been rising rapidly with an increased burden to the healthcare system. As such T2D prevention is highly recommendable, and, theoretically, it can definitely be successful.
- Trial name
- PRE-MED2 (NCT05147961)
- Testing
- Digital Health, Standard care
- Where
- 2 sites in Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Hypophosphatasia, Bone Diseases, Metabolic
Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia
The aim of the study is to accomplish a complete bone status of patients with HPP using new approaches to assess bone quality.
- Conditions
- Hypophosphatasia, Bone Diseases, Metabolic, Bone
- Trial name
- NCT04018287
- Testing
- HR-pQCT scans, BMD measurements, bone specific circulating microRNAs (miRNAs)
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Muscle Function
Muscle in Obesity: Imaging, Function and microRNA
Growing evidence suggests that dynapenic abdominal obesity is associated with a greater risk of falls, functional disability and hospitalisation compared to those with dynapenia, obesity or neither phenotype.
- Trial name
- NCT04300504
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Extracellular Vesicles
Characterization of EVs (Extracellular Vesicles)/miRNAs (microRNAs) From Human Follicular Fluid
Background Extracellular vesicles (EVs) are membrane-bound vesicles found in all biological fluids. They contain various regulatory molecules, including microRNAs (miRNAs).
- Trial name
- NCT07148284
- Testing
- Isolation of EVs + RNA sequencing
- Where
- Belgium
- Volunteers
- 14 people
- Sponsor
- University Hospital, Ghent
Obesity, Liver Disease Parenchymal
Changes in the Lipidomic, Immunological and miRNA Profile in Patients Undergoing a Dietary Program or Bariatric Surgery
Obesity is a chronic disease characterized phenotypically by an increase in body weight (BMI>30 kg/m2) and by a series of associated pathologies, such as hypertension, diabetes, hepatic steatosis.
- Trial name
- NCT06372015
- Testing
- Nutritional Approach, Surgery Approach
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis