Clinical trials: Microbial Composition
Diet Habit, Microbial Colonization
Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity
Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship.
- Conditions
- Diet Habit, Microbial Colonization, Activity, Motor
- Trial name
- PerOME (NCT04766528)
- Testing
- 3 maximal aerobic tests
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Laval University
Microbial Colonization
Non-caloric Sweeteners Levels in Breast Milk and Newborn's Blood and Effect on Microbiota's Composition.
This study evaluates the presence and quantity of non-caloric sweeteners in newborns umbilical cord blood, and in their mother's breast milk at delivery, at 2 months, 4 months and 6 months of age.
- Trial name
- NCT03912038
- Testing
- No intervention.
- Where
- Mexico
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
CRPS
Complex Regional Pain Syndrome (CRPS) and the Gut-bacteria
The purpose of this study is to investigate, for the first time, whether gut bacteria composition and function of patients with CRPS differ from those of healthy adults.
- Trial name
- NCT05473338
- Testing
- Stool and blood samples, Physical examination, Questionnaires
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
GI Health, Microbial Composition
Polyphenol/Prebiotic Blend Effects on GI Health and Microbial Composition
The gastrointestinal (GI) ecosystem is a complex network of bacterial cells, host cells and tissues that change with age. Fewer numbers and less diversity of beneficial bacteria and greater number and diversity of non-beneficial…
- Trial name
- NCT02743195
- Testing
- Polyphenol/prebiotic blend
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Healthy
Randomized Study on Salt Intake and Energy Metabolism
To perform a randomized, double-blind clinical study on the effects of an increased salt intake on metabolic, cardiovascular and immunological parameters and the gut microbiota
- Trial name
- TS4 (NCT03024567)
- Testing
- Salt
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Personalized Nutrition
N=1 Trials of Individual Variability in Post-prandial Glycemic Responses to Diets of Varying Macronutrient Composition
The key objective of this study is to identify the most suitable diet (i.e. high protein, high fat, low GI, high GI) for an individual.
- Trial name
- NCT05402085
- Testing
- High Protein Diet, High Fat Diet, High Carbohydrate-Low Glycemic Index Diet
- Where
- Singapore
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Obesity
Comparison of the Microbial Composition in Lean and Obese Subjects
Rationale: The microbial composition in the small intestine (SI) differs largely from the composition in feces. Many physiological processes related to health, such as immunoregulation and metabolic programming, mainly take place…
- Trial name
- DUPLO (NCT03075228)
- Testing
- IntelliCap
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Sex Hormones, Microbial Colonization
The Relationship of the Intestinal Microbiome and the Menstrual Cycle
In the present study the dynamic changes of the intestinal microbiome are observed over a 4-week period in the different stages of the menstrual cycle in women at childbearing age.
- Trial name
- NCT03581201
- Testing
- Laboratory measurements, Stool samples, Bioimpedance analysis
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Obesity, Childhood, Cognition
NiPPeR Randomised Trial - Child Follow Up Study
There is an increasing focus on the need to optimise nutrition, lifestyle and metabolism of parents before and during pregnancy and of the infant after birth, but as yet there is limited understanding of the specific influences…
- Conditions
- Obesity, Childhood, Cognition, Neurobehavioral Manifestations, Metabolic Disturbance
- Trial name
- NiPPeR Child (NCT05934422)
- Testing
- Intervention (Study Nutritional Drink), Control (Standard Nutritional Drink)
- Where
- 3 sites in New Zealand, Singapore and 1 more
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Obesity (Disorder)
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.
The goal of this clinical trial is to understand how gallotannin-rich (GT-rich) mangoes can reduce the inflammatory markers in obese individuals in vitro.
- Trial name
- NCT07505212
- Testing
- Gallotannin-rich mango, Lactiplantibacillus pentosus (probiotic), No Treatment Added
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prairie View A&M University
Caesarean Section;Stillbirth, Microbial Colonization
Lactobacillus Kefiri LKF01 (DSM32079) in Newborns Born by Caesarian Section
The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life.
- Trial name
- NCT03154866
- Testing
- Lactobacillus kefiri LKF01 DSM32079
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Microbial Colonization
Effect of a Multi Strain Probiotic on the Gut Microbiota
Over recent years there has been a lot of research looking at how the bacteria in our gut affect our health. Changes to gut bacteria has been linked to several diseases.
- Trial name
- NCT04554641
- Testing
- Fasted breath samples, Daily Diary, Stool sample
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Functional Gut Clinic
Diabetes, Heart Diseases
Personalized Responses to Dietary Composition Trial 3
The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- NCT04735835
- Testing
- Dietary Intervention
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- Zoe Global Limited
Vitamin B 12 Deficiency
The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota
Vitamin B12 plays important roles in DNA synthesis and neurological functions. Vitamin B12 deficiency is one of the most common micronutrient deficiencies and it has become increasingly more frequent in infants.
- Trial name
- NCT03365583
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Marmara University
Microbial Composition, Immune Function
Gut Microbiome Response to Long-Haul Travel in Elite Football Players
The goal of this randomised control trial is to measure the gut microbiome response to long-haul travel alongside the demands of pre-season amongst elite football players.
- Trial name
- NCT07585474
- Testing
- Probiotic Capsule
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Diabetes, Heart Diseases
Personalised Responses to Dietary Composition Trial
The foods we eat - our diet - can affect whether we develop diseases during our lives, such as diabetes or heart disease. This is because the amount and types of foods we eat can affect our weight, and because different foods are…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- PREDICT (NCT03479866)
- Testing
- Dietary intervention
- Where
- United Kingdom
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Microbial Community in Breast Milk
Microbial Composition of Breast Milk Collected From Healthy Turkish Women
Breast milk is an optimal source of nutrients for newborns as well as a potential source of bacteria for the intestinal microbiota.
- Trial name
- NCT04072627
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Pilot Study
How Differences in the Composition of Microorganisms in the Soil Affect the Microorganisms in the Human Gut, Through the Vegetables That Grow in it: a Process Pilot Study With Healthy Participants
There are two objectives for this clinical trial. The first is to test whether, with the current logistics and study setup it is possible to perform the study well and see where there might be bottlenecks we couldn't predict.
- Trial name
- HUMANITAS (NCT07742319)
- Testing
- Low diversity vegetable smoothie, High diversity vegetable smoothie
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Healthy, Healthy Nutrition
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial
The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B.
- Trial name
- BEGIN (NCT06452199)
- Testing
- B. infantis
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
Effects of Arabinoxylan-Oligosaccharides Compared to Other Prebiotics in Healthy Subjects
The purpose of the study is to evaluate the effects of arabinoxylan-oligosaccharides (AXOS) on the colonic metabolism and microbial composition, and to compare these effects with the reference prebiotic fructo-oligosaccharide…
- Trial name
- NCT00853034
- Testing
- FOS-IN, AXOS
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- KU Leuven