Clinical trials: Microbial Keratitis
Infectious Keratitis
Investigation of the Microbiome of the Cornea in Microbial Keratitis
Design: Prospective observational diagnostic study and methods-comparison. Aims: The overall aim of the project is to better define the pathogenic microorganisms in patients with microbial keratitis (MK) through a better…
- Trial name
- STOICA (NCT04030403)
- Where
- United Kingdom
- Volunteers
- 219 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Microbial Keratitis
Microbial Keratitis Sampling for Biomarker Discovery
The goal of this observational study is to identify prognostic and/or diagnostic signatures (biomarkers) related to microbial keratitis outcomes.
- Trial name
- NCT05888883
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Bacterial Keratitis, Fungal Keratitis
The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study
This study is an observational prospective cohort study which aims to generate an antibiogram and to assess the clinical responses and outcomes of microbial keratitis patients, treated with empiric topical antimicrobial…
- Conditions
- Bacterial Keratitis, Fungal Keratitis, Mixed Bacterial and Fungal Keratitis, Microbial Keratitis
- Trial name
- NCT05655689
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ceftazidime 5% + vancomycin 5%, Gentamicin 1.4% + vancomycin 5%
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Alexandria University
Corneal Ulcer (Diagnosis)
Diagnosing Corneal Infection
Microbial keratitis is a common and serious eye disease in Edinburgh. Prompt treatment with antibiotics can prevent sight loss, and identification of the micro-organism and its antibiotic sensitivities are key to appropriate…
- Trial name
- NCT04230811
- Testing
- Corneal impression membrane (Millicell Cell Culture Insert, 12mm, hydrophilic PTFE 0.4µm (PICM01250))
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Keratitis, Ulcerative, Antibiotic Resistance, Microbial
Au-Ag-Cu2O NG With PTT Anti Drug-resistant Microbial Keratitis
This clinical study was conducted to evaluate the efficacy and safety of gold-silver cuprous oxide composite nanogels combined with photothermal therapy system in the treatment of severe drug-resistant bacterial keratitis…
- Conditions
- Keratitis, Ulcerative, Antibiotic Resistance, Microbial, Photothermal Therapy
- Trial name
- NCT05268718
- Testing
- Hollow gold and silver alloy cuprous oxide shell nano-shell hydrogel, Voriconazole eye drops, Normal saline
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Infectious Keratitis
Non-invasive Diagnostics of Microbial Keratitis
Infectious keratitis is a significant cause of partial vision loss and blindness and places a large burden on eye care professionals.
- Trial name
- NCT06364878
- Testing
- In vivo confocal microscopy, Tear film sampling
- Where
- Norway
- Volunteers
- 125 people
- Sponsor
- Sorlandet Hospital HF
Infectious Keratitis, Microbial Keratitis
Use of a New Method for the Microbiological Diagnosis of Severe Corneal Infection
Microbial keratitis is a severe and often blindness-inducing pathology which represents today the first reason for long-term hospitalization (more than 5 days) in ophthalmology.
- Conditions
- Infectious Keratitis, Microbial Keratitis, Corneal Infection
- Trial name
- ABCORFILM (NCT05888987)
- Testing
- PCR multiplex by FilmArray
- Where
- France
- Volunteers
- 46 people
- Sponsor
- CHU de Reims
Keratitis; Infectious Disease (Manifestation)
Pseudomonal Type Three Secretion System and Contact Lens Associated Microbial Keratitis
Microbial infection of the cornea, also known as microbial keratitis, causes severe corneal inflammation that could result in permanent visual loss.
- Trial name
- NCT01925846
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Keratitis, Microbial Keratitis
Pattern of Microbial Keratitis in Assiut University Hospital
The aim of the study is to explore the epidemiology, including risk factors, causative microorganisms, complications and clinical outcomes of microbial keratitis among patients attending cornea clinic at Assiut University…
- Trial name
- NCT07316244
- Testing
- corneal scraping including direct smear, culture and sensitivity
- Volunteers
- 100 people
- Sponsor
- Assiut University
Infective Keratitis
Microbial Keratitis in Cairo University Hospitals
The aim of the study was to identify the incidence of infective keratitis presenting to the ophthalmology emergency department at Cairo University hospital, the risk factors and the bacterial/fungal spectrum causing the ulcers…
- Trial name
- NCT05387993
- Where
- Egypt
- Volunteers
- 85 people
- Sponsor
- Kasr El Aini Hospital
Keratitis
Ozone-based Eye Drops as Adjuvant Therapy in Microbial Keratitis
To compare the therapeutic effect of ozone-based eye drops as an adjuvant therapy to that of the conventional topical antimicrobial agents in patients with microbial keratitis .
- Trial name
- NCT05689996
- Testing
- Ozone-Based Agent
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Keratitis
Automated Quantitative Ulcer Analysis Study
This is a multiple site observational study that will review patient features (clinical and morphologic) over a 90 day period during care of participants with microbial keratitis with presence of clinically significant ≥2mm…
- Trial name
- AQUA (NCT04420962)
- Testing
- Visual Acuity
- Where
- 2 sites in United States, India
- Volunteers
- 124 people
- Sponsor
- University of Michigan