Clinical trials: Microbiological Study
Chronic Periodontitis
Decontaminant Agent in the Treatment of Chronic Periodontitis
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence of the decontaminant tools for the management of Chronic Periodontitis (cp), the aim of this study was to…
- Trial name
- NCT02657096
- Testing
- Hybenx treatment (device), Scaling and Root Planing (SRP)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Messina
Patients With Deep Carious Lesions
Clinical Evaluation and Microbiological Assessment of Diode Laser and Chemical Disinfection in Comparison to Selective Caries Removal
Objectives: To evaluate the clinical and antimicrobial effect of Diode laser and chemical disinfection in comparison to selective caries removal in management of deep carious lesions.
- Trial name
- NCT03955341
- Testing
- Diode laser disinfection, Chemical disinfection using 2% Chlorhexidine
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Misr International University
Community-Acquired Infections, Pneumonia
Community-acquired Pneumonia in Buskerud County in Norway
The purpose of this study is to determine the etiology of community-acquired pneumonia, to assess risk factors and to investigate potential prognostic biomarkers of serious disease and fatal outcome.
- Trial name
- NCT01563315
- Where
- Norway
- Volunteers
- 270 people
- Sponsor
- Vestre Viken Hospital Trust
Infantile Colic
Lactobacillus Reuteri Versus Placebo in the Treatment and Prevention of Infantile Colic
The purpose of this study is: to study the intestinal microflora of colicky infants before and after L. reuteri or placebo administration, evaluating the effect of Lactobacillus reuteri on the growth of the main intestinal…
- Trial name
- NCT00893711
- Testing
- Lactobacillus reuteri DSM 17938, L.reuteri + Vit D
- Where
- 3 sites in Italy
- Volunteers
- 155 people
- Sponsor
- Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna
Functional Constipation
The Efficacy of a Probiotic for Functional Constipation (FC)
Investigate the effect of a probiotic (live bacteria) in individuals with functional constipation.
- Trial name
- SLOG (NCT06083311)
- Testing
- Probiotic
- Where
- Germany
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Head and Neck Infection
Microbiology Studies of Acute Head and Neck Infections
Acute head and neck infections cause significant pain and discomfort for patients and impact on their quality of life. Effective antibiotic and surgical treatments have been developed for these infections but they are still able…
- Trial name
- NCT05874908
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- The University of Northampton
Adhesiveness
Bar and Ball Joint Overdentures Surface Roughness and Microbial Adherence
The aim of the study was to compare the surface roughness (Ra) of the implant retained mandibular bar overdenture (BOD) and the implant retained mandibular ball joint overdenture (BJOD) in jaw and its relation with the adhesion…
- Trial name
- NCT03256409
- Testing
- Adherence mold and yeast and mesophyll aerobe, Surface Roughness (Ra)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Gastrovital
Periodontitis and Diabetes, Periodontitis
Clinical Efficacy of Local Delivery of Minocycline and Hyaluronan Gel to Treat Periodontitis in Diabetic Patients
The goal of this clinical trial is to investigate the local delivery of minocycline gel 2% and 0.2% hyaluronan gel to treat periodontitis in diabetic patients as adjunctive to subgingival instrumentation.
- Trial name
- NCT06997731
- Testing
- Non -surgical treatment and oral hygiene instruction, Application of minocycline and hyaluronic acid gel.
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kafrelsheikh University
Periodontitis, Clindamycin Gel
Comparing Aloe Vera Gel and Clindamycin Gel Added to Scaling and Root Planing for Periodontitis
Periodontitis is an inflammatory disease affecting the tissues that support the teeth. Scaling and root planing is a standard nonsurgical treatment, but additional local treatments may help improve clinical periodontal outcomes…
- Conditions
- Periodontitis, Clindamycin Gel, Aloe Vera Gel, Scaling and Root Planing
- Trial name
- NCT07900802
- Testing
- Scaling and Root Planing
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Dental Caries
A Study to Evaluate the Safety and Microbiology of C16G2 Varnish Administered in Multiple Doses to Dental Subjects
The purpose of this single-blind study is to evaluate whether C16G2 Varnish administered in multiple doses can effectively kill the bacteria in the oral cavity that cause dental caries.
- Trial name
- NCT03004365
- Testing
- C16G2 Varnish
- Where
- 3 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Bronchiectasis
The PROspective German NOn-CF bronchiectaSIS Patient Registry
The purpose of this study is to study the epidemiology of non-CF bronchiectasis (NCFB) and to provide an estimate of the distribution (prevalence) of NCFB etiologies across all different levels of health care as well as real-life…
- Trial name
- PROGNOSIS (NCT02574143)
- Where
- 19 sites in Germany
- Volunteers
- 750 people
- Sponsor
- Hannover Medical School
Pocket Depth, Attachment Loss
Clinical and Microbiological Outcomes of Dental Implants After 10-22 Years of Function
Aim: the aim of this retrospective study is to present long-term data (10+ years of functional loading) on the success and survival of ZimVie (3i) implants.
- Conditions
- Pocket Depth, Attachment Loss, Bone Loss in Jaw
- Trial name
- NCT06803576
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Orthodontics
Personalised Prevention of Microbiological Homeostasis in the Oral Cavity During Fixed Orthodontic Treatment
Oral dysbiosis systematically develops during orthodontic treatment [35][36]. Orthodontic appliances interfere with oral hygiene procedures and cause biofilm to accumulate, creating new retention zones, even in subjects who…
- Trial name
- PREPERMIO (NCT06752902)
- Testing
- Standard Care Arm, standard care combined with personalised prevention
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Childhood Pneumonia, Pneumococcal Carriage
The Study of Chest Infections in Infants Living in a Refugee Camp on the Thai-Burmese Border
This study will follow 1000 refugee infants from birth for two years. The aim of the study is to better understand why some children develop infections caused by the bacterium Streptococcus pneumoniae whilst others merely carry…
- Trial name
- ARI (NCT00894764)
- Where
- 2 sites in Thailand
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Vitamin D Deficiency, Cystic Fibrosis
Vitamin D and Microbiota in Cystic Fibrosis
The objective of this study is to assess the effects of a high-dose vitamin D3 on the composition of gut and lung microbiota in adolescents and adults with cystic fibrosis who are vitamin D deficient.
- Trial name
- NCT02589444
- Testing
- High-Dose Vitamin D3, Stool Sample, Sputum Sample
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Emory University
Protracted Bacterial Bronchitis
Antibiotics, Microbiology and Immunology in Children With Chronic Wet Cough - the AMIC Study
The AMIC study is a double-blind, placebo-controlled, multicenter, nationwide, randomized controlled academic pharmaceutical trial.
- Trial name
- AMIC (NCT06020716)
- Testing
- Amoxicillin-Clavulanate 400 Mg-57 Mg/5 mL Oral Powder for Reconstitution
- Where
- 7 sites in Norway
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Constipation - Functional
Physiological, Microbiological and Metabolomic Effects of Fruit Products
This study is a randomised, parallel group, controlled trial, comparing the effects of fruit products as to their physiological, microbiologic and metabolomic effects on the gut, as well as their effects on the dietary intake and…
- Trial name
- NCT04086134
- Testing
- Fruit Products
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- King's College London
Periapical Periodontitis
Comparison of Root Canal Desinfection Protocols
Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis
- Trial name
- NCT07439614
- Testing
- Desinfection device, Analytical microbiological methods
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Brain Abscess
Circulating Cell-Free DNA for Brain Abscess Diagnosis: A Pilot Study
Brain abscess is a severe intracranial infection associated with significant morbidity and mortality. Standard management combines neurosurgical intervention, when feasible, with prolonged intravenous antibiotic therapy.
- Trial name
- METABCES-PoC (NCT07479225)
- Testing
- Plasma Microbial Cell-Free DNA Metagenomic Sequencing
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Persistent Infection, Periapical Lesion
The Effectiveness of Hyperpure Chlorine Dioxide and Sodium Hypochlorite Irrigants in Endodontic Retreament in RCT
Endodontic treatment aims to eliminate pathogenic microbes from the root canal. Hyperpure chlorine dioxide is an endodontic irrigant.
- Trial name
- NCT04954638
- Testing
- endodontic desinfection
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- Eniko Vaszine Szabo