Clinical trials: Microbiome
Healthy
Effect of 12-week Probiotic Consumption Immobilized on Oat Flakes on Blood and Urine Biomarkers and Human Microbiome
The purpose of this clinical trial was to evaluate the effects Lactococcus cremoris spp. im-mobilized on oat flakes on human microbiome and blood and urine biomarkers of associated with human health.
- Trial name
- FOODBIOMES CT2 (NCT06293859)
- Testing
- Probiotic oat flakes, Conventional oat flakes
- Where
- Greece
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of the Aegean
Hypertension, Cardiovascular Diseases
Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN )
Nitric Oxide (NO) is an important molecule that is produced naturally in the body and that helps maintain healthy blood flow. Low availability of NO contributes to many diseases while administration of NO is therapeutic.
- Conditions
- Hypertension, Cardiovascular Diseases, Diabetes
- Trial name
- OPEDNPN (NCT06375694)
- Testing
- Herbiotics Oral + Ent Probiotic
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Gastrointestinal Microbiome
Benefits of Alcoholic Hangover Medicine
Myrkl is advertised as a dietary supplement for use before alcohol consumption that is effective in prevention of side effects during the next day.
- Trial name
- BLAM (NCT06126094)
- Testing
- Myrkl, dextrin
- Where
- Croatia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- The Gut Microbiome Center (Centar za crijevni mikrobiom)
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Healthy
The Effect of a Postbiotic on Oral Health in Healthy Adults
The goal of this randomised, placebo-controlled trial is to determine the effect of a chewable postbiotic tablet on the oral health of male and female healthy adults under conditions of short term oral-neglect (a short, temporary…
- Trial name
- LOOFAH2 (NCT07830862)
- Testing
- Postbiotic
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- The Archer-Daniels-Midland Company
Inflammation Gastrointestinal Tract
Identifying the Microbial Metabolome: The Missing Link Between Diet and Human Health
There is a lot of evidence to suggest that the bacteria in our gut play a major role in maintaining our health, but very little is known about the way in which this is achieved.
- Trial name
- NCT07591961
- Testing
- Food
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Endothelial Dysfunction, Aging
Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults
Aging is the primary risk factor for cardiovascular disease (CVD) largely due to vascular endothelial dysfunction, a major initial step in the development of atherosclerosis.
- Trial name
- NCT03824041
- Testing
- Aronia full spectrum - half dose, Aronia full spectrum - full dose
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Obesity
The Effect of Prebiotic Fibres on Weight Loss in an Overweight and Obese Population
The aim of this study is to investigate whether a diet supplemented with two prebiotic fibres induces greater changes in body weight compared to placebo during 12 weeks of energy restriction in an obese/overweight population.
- Trial name
- MNGII (NCT03135041)
- Testing
- Fiber-containing dietary supplement
- Where
- Denmark
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Age-related Cognitive Decline
Study on the Chronic and Acute Effects of Nordic Berry Beverage on Cognitive Function
The aim of the current study is to investigate whether acute and 12-weeks daily intake of Nordic berries can improve cognitive abilities of adults without cognitive disease, and whether the effect can be linked to changes in…
- Trial name
- SCANBerry (NCT05693441)
- Testing
- Active berry product, Reference berry-like product
- Where
- Sweden
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Aventure AB
Short Gut Syndrome
Successful Fiber Food Introduction in Short Bowel Syndrome
Short bowel syndrome (SBS) is a rare but challenging condition in which patients have insufficient bowel length to meet fluid, electrolyte, and nutrient requirements without parenteral support.
- Trial name
- GREENBEANS (NCT06240065)
- Testing
- Green bean puree
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Irritable Bowel Syndrome Mixed
The Effect of AI-based Microbiome Diet on IBS-M Symptoms
This study was designed as a pilot, open-labelled study. We enrolled consecutive IBS-M patients (n=25, 19 females, 46.06 ± 13.11 years) according to Rome IV criteria.
- Trial name
- NCT04768387
- Testing
- Personalized microbiome diet
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Gazi University
Healthy
Pubic Hair and the Urinary and Vaginal Microbiome
This research study seeks to find if there is a connection between the presence of pubic hair and the type of bacteria that live in the vagina and bladder.
- Trial name
- NCT03272204
- Testing
- No pubic hair, Pubic Hair
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Margaret Mueller
Oral Health
Dysbiosis of Methanogenic Archaea and Nanoarchaea in the Oral Microbiome
Need to improve understanding of oral dysbiosis in the elderly and/or immunocompromised individuals (involvement of nanogenes in these dysbiosis) Comparison of dysbiosis identification between results from dental plaque samples…
- Trial name
- METHAORAL (NCT07521644)
- Testing
- Dental plaque sample, Saliva sample
- Where
- France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Microbiota, Dental Implants
Microbiome Development in the Early Healing of Osseointegrated Implants
The aim is to compare the microbiome composition on the first month of healing and 2 years after rehabilitation in two different implant surfaces (SLA® vs SLActive®).
- Trial name
- PiMicrobiome (NCT05941663)
- Testing
- Dental implant surface
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Healthy Volunteers, Nitric Oxide
Evaluation of Adding Nitrate Into Foods for Regulating Nitric Oxide Bioavailability in Healthy Individuals
Inorganic nitrate, found in leafy green vegetables and beetroot, can help lower blood pressure and support heart health. Early experimental work has suggested that dietary nitrate supplementation, in the form of beetroot juice or…
- Conditions
- Healthy Volunteers, Nitric Oxide, Vascular Function
- Trial name
- NCT07172425
- Testing
- Inorganic potassium nitrate-fortified biscuits supplementation, Inorganic potassium nitrate-fortified cereal bar supplementation, Inorganic potassium nitrate-fortified porridge supplementation
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Healthy
Dietary Fiber and Gut Microbiome Study
The purpose of this dietary intervention is to study the effects of several dietary fibers on the gut microbiota at the personal level.
- Trial name
- NCT05424640
- Testing
- Dietary fiber 1, Dietary fiber 2, Dietary fiber 3
- Where
- Estonia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Center of Food and Fermentation Technologies
Gut Microbiome, Skin Microbiome
The Influence of Oral Probiotics on the Microbiome and Lipidome
The purpose of this study is to measure oil production of the face, facial properties, and gut bacteria in people being given oral probiotics.
- Conditions
- Gut Microbiome, Skin Microbiome, Gut Lipidome, Skin Lipidome
- Trial name
- NCT03605108
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Obesity
Glycomacropeptide and Women's Health
This is a study about how a dietary supplement containing a whey protein affects hormones controlling hunger and satiety (leptin and ghrelin) in postmenopausal women with a body mass index between 28 and 35 kg/m2.
- Trial name
- GMP (NCT05551091)
- Testing
- glycomacropeptide (GMP)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Caries, Dental
Caries Removal Methods and Microbiome Changes
Dental caries management approaches may influence not only tissue removal but also the microbial composition within the cavity. However, clinical evidence on how different caries removal methods affect the oral microbiome remains…
- Trial name
- NCT07538089
- Testing
- Non-selective caries removal, Selective caries removal
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nuh Naci Yazgan University
Inflammatory Bowel Diseases
Preoperative Oral ImmunoNuTrition to Improve Surgical Outcomes for IBD Patients (PINT)
The central focus of this trial is to understand the effectiveness of Preoperative Immunonutrition (PINT) in improving surgical outcomes for patients with inflammatory bowel disease (IBD).
- Trial name
- PINT (NCT03333148)
- Testing
- Nestle IMPACT Immunonutrition, Arm B- Standard of Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
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