Clinical trials: Microbiome Analysis
Dry Eyes
Ocular Surface Dry Eye Microbiome
The investigators seek to characterize the identity of all microorganisms residing on the eye's surface (conjunctiva) in healthy eyes and those with dry eye syndrome, using a combination of analyses.
- Trial name
- NCT02306668
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Washington
Microbiome Analysis, Drug Abuse in Pregnancy
Alcohol and Cannabis Use Among Pregnant Slovenian Women
The aim of the study is to determine the prevalence of alcohol and drug use among Slovenian pregnant women. Alcohol and drug use during pregnancy has significant effects on the foetus and has short- and long-term health…
- Conditions
- Microbiome Analysis, Drug Abuse in Pregnancy, Alcohol Abuse in Pregnancy, Health Behavior, Risky
- Trial name
- NCT07456579
- Where
- Slovenia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Inflammatory Bowel Diseases, Crohn Disease
Predicting IBD Treatment Outcomes With Gut Microbiome Analysis
The goal of this prospective observational study is to determine if specific microbiome signatures can predict therapeutic responses in adult patients with Crohn's disease (CD), a form of inflammatory bowel disease (IBD), living…
- Trial name
- OPTIMIST (NCT06453720)
- Testing
- Colonoscopy
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Infertility of Uterine Origin
Development of a Microbiome Non-invasive Diagnosis Tool
Although the endometrium tissue has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome.
- Trial name
- ERA-niMIC (NCT03330444)
- Testing
- Endometrial biopsy and endometrial fluid collection
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Igenomix
Obesity
Gut Microbiome Based Analysis of High Protein High Fat Diet
The aim of this study was to determine body mass reduction and microbiota composition change after the weight loss diet (50 % fat, 25 % proteins and 25 % carbohydrates).
- Trial name
- NCT04681664
- Testing
- High fat diet
- Where
- Estonia
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Center of Food and Fermentation Technologies
Diet, Healthy, Breath Analysis
Why Calories Are Not the Same - a Gut Explanation?
The aim of this study is to understand how the gut microbiome influences how much dietary energy humans excrete via feces. This study is based on the hypothesis that levels of methane in exhaled breath represent two different gut…
- Trial name
- GutEnergy (NCT06932666)
- Testing
- Diet A group, Diet B group
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy
FoodStep - a Sustainable Model for Food Services and Early Childhood Education and Care
Transformation towards a more climate-friendly and healthy sustainable diet will require major changes in the food system: increase in consumption of plant-based foods and only moderate consumption of animal-based foods.
- Trial name
- NCT05249946
- Testing
- FoodStep - a sustainable health-promoting model for food services and early childhood education and care
- Where
- Finland
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Suvi Virtanen
Healthy
Multi-omics Database Construction of Healthy Korean Volunteers
The goal of this prospective, observational study is to collect health-related data including microbiome, blood samples, and dietary habits from the oral and gastrointestinal tracts in healthy subjects.
- Trial name
- NCT06183697
- Where
- South Korea
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Helicobacter Pylori Infection
Analysis of the Impact of Helicobacter Pylori on Salivary Microbiome in Adults
Helicobacter pylori (H. pylori), a bacteria transmitted from human to human through upper digestive tract as well as fecal-oral transmission, had infected more than half of people around the world. However, the quantity of H.
- Trial name
- NCT03730766
- Testing
- Esomeprazole, Amoxicillin, Bismuth Potassium Citrate
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Healthy
Comparison of Different Methods for the Analysis of Gut Microbiome Composition
The human gastrointestinal tract shelters a complex and dynamic population of microorganisms, the gut microbiota, which plays an important role in immune and metabolic homeostasis.
- Trial name
- COLLECT (NCT04082221)
- Testing
- no intervention
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis
Multi-Omics Integrative Analysis of Serum and Sputum to Uncover Key Determinants of Prognosis in Patients With ARDS
This study is a prospective observational investigation designed to systematically characterize key microbial signatures, metabolite profiles, and gene-expression features in serum and sputum from patients with acute respiratory…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Microbiome Dysbiosis, Multiomics Analysis, Metabolomics
- Trial name
- NCT07380997
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Biliary Atresia
Gut Microbiome in Biliary Atresia
The investigator will investigate the gut-microbiome and liver elasticity of the Biliary Atresia (BA)-patients before and after Kasai operation.
- Trial name
- NCT04260503
- Testing
- Monitoring of the gut-microbiome and ultrasound elasticity., Monitoring of the gut-microbiome, Monitoring of the gut-microbiome.
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Retinopathy of Prematurity, Microbiome
The Analysis of Association of Retinopathy of Prematurity, Gut Microbiome Profile, and Systemic Inflammation
Study Aims 1. Understanding the gut microbiome profile in very low birth weight infants with or without ROP. The onset and aggravation of ROP and their relationship with gut microbiome will be examined. 2.
- Trial name
- NCT05144282
- Testing
- intravitreal injection of anti VEGF, laser photocoagulation
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Monoclonal Gammopathy of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM)
Integrative Multi-omics Analysis to Predict Monoclonal Gammopathies Clinical Evolution
This prospective, multicenter, observational study aims to identify molecular and immunological markers associated with disease progression in patients with monoclonal gammopathy of undetermined significance (MGUS) and smoldering…
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Smoldering Multiple Myeloma (SMM), Multiple Myeloma (MM)
- Trial name
- PNRR-2022-1237 (NCT07214324)
- Testing
- Collection of biological material
- Where
- 4 sites in Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp, Apical Periodontitis
- Trial name
- NCT06931678
- Testing
- aPDT
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Hair Loss
For an Investigator-led Hair Study Comparing Between Healthy and Hair Loss Volunteers
This study is to evaluate differences in the gut and follicle/scalp microbiome signature in AGA compared to a non-AGA population.
- Trial name
- NCT07716748
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National Skin Centre
Oxalate, Primary Hyperoxaluria, Microbiome
Descriptive Analysis of Gut Microbiome Alterations in Hyperoxaluric Patients
To characterize the microbiome in 4 groups of subjects (primary hyperoxaluria type I (PH1), idiopathic CaOx stone, enteric hyperoxaluria (EH) and healthy participants) by comparing the number of species and diversity of the…
- Trial name
- NCT02794649
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VA New York Harbor Healthcare System
Glucose Metabolism Disorders, Health Behavior
Relationship Between Individual Effect of Diet on Postprandial Glycemia and Gut Microbiome Profile in Healthy Subjects
When all the food we eat is digested, it will increase blood glucose. Two people can have different glucose blood levels to the same food and one reason can be bacteria live in our gut.
- Conditions
- Glucose Metabolism Disorders, Health Behavior, Diabetes, Metabolic Disease
- Trial name
- NCT06051318
- Testing
- Standardized breakfast A, Standardized breakfast B
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- BiomeHub Biotechnology Company
Gastric Intestinal Metaplasia, Gastric Cancer
Microbiome Analysis in Gastric Intestinal Metaplasia and in Gastric Cancer and Subtypes Correlation
The aim of the study will be to analyze the microbiome in the blood and stomach in patients with intestinal metaplasia (IM) and / or gastric cancer (GC).
- Conditions
- Gastric Intestinal Metaplasia, Gastric Cancer, Microbiome
- Trial name
- NCT04365946
- Testing
- Gastroscopy
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ioannina
Cancer Related Fatigue, Fatigue Syndrome, Chronic
Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME)
Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue Syndrome (CFS/ME) by Lipidomics, Metabolomics, Intestinal and Peritoneal Microbiome Analysis and Exome Analysis and Investigation of a Possible…
- Trial name
- IMPROFA (NCT03773003)
- Testing
- Probiotics
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universität des Saarlandes