Clinical trials: Microbiota
Infant Term Birth
Breastfeeding Study
The purpose of this study is to evaluate the stool consistency and microbiota composition of healthy breastfed infants.
- Trial name
- NCT03387124
- Testing
- Breastfed infants
- Where
- Philippines
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy Volunteer
A Study to Compare the Effect of Omadacycline Versus Moxifloxacin in Healthy Adult Volunteers
This is a randomized (1:1), double-blind, double-dummy, phase I study to compare the effects of Omadacycline versus Moxifloxacin on gut microbiota and the resistomes in healthy adult volunteers.The study consists of 3 phases…
- Trial name
- NCT06462326
- Testing
- Moxifloxacin Oral Tablet, Omadacycline Oral Tablet
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zai Lab (Hong Kong), Ltd.
Atopic Dermatitis
A Study of Lebrikizumab in Adults and Adolescents With Face and Neck Atopic Dermatitis
The main aim of the study is to evaluate the efficacy and safety of lebrikizumab treatment for up to 32 weeks in participants with moderate-to-severe face and neck atopic dermatitis (FNAD) who also have moderate-to-severe AD…
- Trial name
- ADface (NCT07873801)
- Testing
- Lebrikizumab
- Volunteers
- 230 people
- Sponsor
- Almirall, S.A.
Gastrointestinal, Microbiota Balance
The Effects of a Postbiotic Supplement on Biomarkers of Gut Health
This study is a randomized, double-blind, two-arm, placebo-controlled trial of N=80 (40/arm) apparently healthy men and women between 18 and 65 years old to be recruited at a single investigational center in Northeast Ohio (i.e.…
- Conditions
- Gastrointestinal, Microbiota Balance, Microbiota, Cortisol
- Trial name
- NCT07527286
- Testing
- Postbiotic
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Verb Biotics LLC
Patients With Bacterial Vaginosis
Oral Lactobacillus Crispatus LCr86 Reduces Nugent Score and Improves Vaginal Microecology in Women With Intermediate Vaginal Microbiota
Lactobacillus crispatus LCr86 was selected as a test preparation to evaluate its effect on the Nugent score, vaginal pH, vaginal microbiota composition, serum inflammatory cytokines, and functional prediction analyse.
- Trial name
- NCT06830122
- Testing
- Probiotic
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Microbiota
The Impact of MS-20 on Gut Microbiota Composition in Adult Individuals
MicrSoy-20 (MS-20), a fermented soymilk product, has been approved as an Over the counter (OTC) drug in 2011. The therapeutic effect of MS-20 is to ameliorate symptoms such as fatigue and loss of appetite caused by cancer…
- Trial name
- NCT04674839
- Testing
- MS-20
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Microbio Co Ltd
Parkinson Disease
Role of Nasal Dysbiosis in Parkinson Disease
Olfactory dysfunction is frequent in Parkinson Disease (PD) and may be present years before the motor symptoms appear. The early olfactory dysfunction could result from environmental factors acting through the nasal cavity such…
- Trial name
- SMELLPARK (NCT04249245)
- Testing
- Nasal Swab
- Where
- 2 sites in France, Guadeloupe
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Antibiotic-associated Diarrhoea
Effect of Probiotic Formula on Reducing the Risk for Antibiotic-associated Diarrhoea
Antibiotic treatment disturbs the balance of the intestinal microbiota and predisposes to antibiotic associated diarrhea. Previous studies have shown that the risk of developing diarrhea during a course of antibiotics may be…
- Trial name
- NCT01596829
- Testing
- Probiotic
- Where
- Finland
- Volunteers
- 258 people
- Sponsor
- Danisco
Alzheimer Disease
Evaluation of the Effect of Wismemo on Alzheimer's Dementia Patients
The present studies demonstrated that pro-inflammation, systemic oxidative stress and dysfunction in the brain-gut microbiota axis were involved in Alzheimer's disease (AD) pathogenesis.
- Trial name
- NCT04094129
- Testing
- Wismemo
- Sponsor
- GenMont Biotech Incorporation
Insulin Sensitivity, Overweight or Obesity
Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human
Objective 1: Characterize indices of systemic inflammation and gut microbiota composition and function after chronic (12 weeks) intake of pulses compared to control diet in human OW/OB-IR participants.
- Conditions
- Insulin Sensitivity, Overweight or Obesity, Inflammatory Response
- Trial name
- PS (NCT04267705)
- Testing
- Control, Black bean, Chickpea
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Body Weight Changes, Metabolic Syndrome
Evaluation the Effect of AKK Formula on Intestinal Microbiota Regulation and Body Composition
The AKK formula, a prebiotic blend, can effectively promote the proliferation of A. muciniphila. In this study, we attempt to explore the clinical efficacy of AKK formula for A. muciniphila proliferation and weight management.
- Trial name
- NCT06132269
- Testing
- AKK formula prebiotic sachet
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Women's Health
A Study Assessing the Impact of a Women's Health Formulation on Vaginal Health and the Microbial Community
An open label study assessing the impact of a women's health formulation on vaginal health and the microbial community
- Trial name
- NCT07036666
- Testing
- Active Product
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Non Small Cell Lung Cancer, Microbiome
BioForte Technology for in Silico Identification of Candidates for a New Microbiome-based Therapeutics and Diagnostics
The goal of the project is to develop and validate the BioForte technology. Its main functionality should be to in silico determine candidates for novel microbiome-based therapeutics and diagnostics.
- Conditions
- Non Small Cell Lung Cancer, Microbiome, Metagenome, Immunotherapy
- Trial name
- NCT04136470
- Testing
- Collection of stool, blood (PBMC) and biopsy (FFPE)
- Where
- 10 sites in Poland
- Volunteers
- 130 people
- Sponsor
- Ardigen
Quality of Life, Health, Subjective
Resistant Starch Blend Gastrointestinal Impact
This study aims to test the hypothesis that a unique blend of resistant starches and fiber will promote gastrointestinal health, as measured by an increase in short-chain fatty acids and improvement in quality of life measures in…
- Trial name
- NCT03983772
- Testing
- RS blend
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Anxiety Depression
Probiotics Regulate Intestinal Health and Alleviate Anxiety
This study is a randomized, double-blind, placebo-controlled trial aimed primarily at investigating the effects of Weizmannia coagulans BC99 on alleviating anxiety and depression and the gut microbiota.
- Trial name
- NCT07353320
- Testing
- probiotics group
- Where
- China
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Immune Function and Intestinal Microbiota
Probiotics on Immune Function and Intestinal Microbiota in Astronauts Under Closed Microgravity Environment
Human immune function and intestinal microbiota are suggested to be altered within long-duration stay in space. Accumulated evidences on earth support that Lacticaseibacillus paracasei strain Shirota (LcS) is a promising…
- Trial name
- NCT02618005
- Testing
- Probiotic capsule
- Where
- Japan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yakult Honsha Co., LTD
Excessive Intestinal Gas Production
Evaluation of a 28-day Fermented Milk Product Consumption Twice Daily as Compared to a Non-fermented Milk Product on Intestinal Gas Production in Healthy Subjects High Dihydrogen Producers
The purpose of this study is to assess the effect of a 28-day fermented milk product consumption twice daily on intestinal gas production of dihydrogen (H2) and methane (CH4) in healthy subjects high H2 producers.
- Trial name
- BREEZE (NCT03015441)
- Testing
- Milk product fermented by lactic bacteria or not fermented
- Where
- Germany
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center