Clinical trials: Microcalcification
Coronary Artery Disease, Hyperlipidaemia
Icosapent Ethyl for High-Risk Coronary Plaques Assessed by 18F-NaF PET/CT
This randomized controlled study will evaluate whether icosapent ethyl (IPE) can improve and stabilize high-risk coronary plaques in patients receiving stable low-density lipoprotein cholesterol (LDL-C)-lowering therapy.
- Conditions
- Coronary Artery Disease, Hyperlipidaemia, Hypertriglyceridaemia, Coronary Atherosclerosis
- Trial name
- IPE-NaF (NCT07762755)
- Testing
- icosapent ethyl (IPE), Standard LDL-C-Lowering Therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Breast Carcinoma, Microcalcification
Ultrasound Imaging Technique in Detecting Breast Microcalcifications in Patients Undergoing Biopsy for a Breast Abnormality
This clinical trial studies a new type of ultrasound technique, MicroPure, in detecting breast microcalcifications in patients undergoing biopsy for a breast abnormality.
- Trial name
- NCT03031561
- Testing
- Ultrasound, MicoPure ultrasound, Biopsy of Breast
- Volunteers
- 85 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Breast Carcinoma
Contrast-Enhanced Mammography for the Evaluation of Mammographic Microcalcifications
This clinical trial evaluates the added role of contrast-enhanced mammography (CEM), as well as imaging and blood biomarkers, for predicting the presence or absence of high-grade ductal carcinoma in situ (DCIS) or invasive cancer…
- Trial name
- NCT05046301
- Testing
- Biospecimen Collection, Contrast Agent, Contrast-Enhanced Mammography
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- M.D. Anderson Cancer Center
Ductal Carcinoma in Situ, Extensive Disease
Impact of Neoadjuvant Hormonal Therapy on the Surgical Management of Extensive Ductal Carcinomas in Situ
Ductal carcinoma in situ (DCIS) accounts for approximately 20% of newly diagnosed breast cancer cases. Of these women, 20% require radical management in the form of mastectomy because of the extent of the lesions, which most…
- Conditions
- Ductal Carcinoma in Situ, Extensive Disease, Mastectomy
- Trial name
- HORNEO01 (NCT04666961)
- Testing
- Tamoxifen 20 mg, Anastrozole 1Mg Tab
- Where
- 8 sites in France
- Volunteers
- 262 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
Molecular Breast Imaging (MBI) in Patients With Suspected Ductal Carcinoma in Situ (DCIS)
In this research study, the investigators are testing a new type of breast camera, called Molecular Breast Imaging, to see if it can find tumors in the subject's breast.
- Trial name
- NCT00890994
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Breast Cancer, Breast Cyst
Advanced Ultrasound Signal Processing of Suspicious Breast Images
This study aims to investigate recent developments in ultrasound signal processing to determine if these new techniques can enhance the visibility of important features of interest in breast ultrasound images.
- Conditions
- Breast Cancer, Breast Cyst, Microcalcification
- Trial name
- AUSPICIOUS (NCT07206888)
- Testing
- Imaging
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Breast Cancer
Vibro-Acoustography Imaging in Finding Breast Microcalcifications and Lesions in Women
RATIONALE: New diagnostic procedures, such as vibro-acoustography imaging, may be an effective method of finding microcalcifications and lesions in the breast.
- Trial name
- NCT00626119
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Breast Cancer, Microcalcification
Prospective Observational Study for Breast Microcalcifications' Classification With Artificial Intelligence Techniques
Breast microcalcifications are a common mammographic finding. Microcalcifications are considered suspicious signs of breast cancer and a breast biopsy is required, however, cancer is diagnosed in only a few patients.
- Trial name
- NCT05767424
- Where
- Italy
- Volunteers
- 1,426 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Breast Cancer, Microcalcification
Imaging Quality and Potential Clinical Relevance of Phase Contrast Mammography In-vivo: a Single-center, Prospective Study
Conventional mammography, breast sonography and breast MRI have specific weaknesses. In particular, mammography has a low sensitivity for the detection of mammary carcinoma in patients with a dense breast.
- Conditions
- Breast Cancer, Microcalcification, Image
- Trial name
- NCT06489665
- Testing
- Experimental Intervention
- Where
- 2 sites in Switzerland
- Volunteers
- 350 people
- Sponsor
- University of Zurich
Cardiovascular Disease, Hyperlipidemia
Effect of Evolocumab on Coronary Atherosclerosis
This study will quantify changes in coronary plaque volumes and plaque composition in patients treated with evolocumab. Previous intravascular ultrasound studies have shown that treatment with a lipid-lowering PCSK9 enzyme…
- Trial name
- NCT03689946
- Testing
- Evolocumab, 18F-NaF PET, CCTA
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Cedars-Sinai Medical Center
Breast Cancer
A Study Comparing ex Vivo MRI Versus Radiography of Breast Specimens
Radiography of breast specimens is currently the only radiological procedure used to verify removal of microcalcifications and presence of tumor-free margins after breast surgical resection.
- Trial name
- NCT01869335
- Testing
- radiography, MRI (magnetic resonance imaging)
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano