Clinical trials: Microcirculation
Sepsis
Infrared Imaging in Septic Illness
The application of infrared thermal imaging in the diagnosis and prognostication of septic illness in adults. During times of severe infection (sepsis), the small blood vessels supplying oxygen and nutrients to the skin and other…
- Trial name
- NCT02855671
- Testing
- Infrared thermal imaging
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
French PNNS Guidelines in Vascular Function
Impact of Dietary Status on Vascular Function Before and After a Standardized Breakfast. An "Exposed/Unexposed" Study Embedded in the SUVIMAX2 Cohort
In France, primary cardiovascular and metabolic prevention is supported by the French National Program for Nutrition and Health (PNNS: Programme National Nutrition Santé).
- Trial name
- Nutri-MicroVas (NCT01579409)
- Testing
- PNNS guidelines
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Old Age (Focus; Not a Recognized Condition)
Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance With Age; the Role of Amino Acids in Modulating Muscle Metabolism
The investigators plan to measure changes in muscle protein metabolism in response to feeding, comparing between a single large essential amino acid (EAA) feed (the normal building blocks of protein) and the provision of the same…
- Trial name
- Ajinomoto1A (NCT01735539)
- Testing
- 15g EAA bolus, 4 x 3.75g Mixed EAA Pulses, 15g EAA Bolus supplemented with 3g Arginine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Sublingual Microcirculation of Healthy Volunteers by Using the Third Generation Microcirculation Video Microscope
This study will enroll 150 healthy volunteers, and the grouping is as follows: group 20-39 (30 males and 30 females); group 40-59 (30 males and 30 females); and group 60-79 (15 males and 15 females).
- Trial name
- NCT02412839
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy Volunteers
Role of Epoxy-eicosatrienoic Acids in Post-occlusive Hyperemia and Thermal Hyperemia
The objective of this proof of concept study is to assess the involvement of epoxy-eicosatrienoic acids (EETs) in post-occlusive hyperemic and thermal hyperemia responses, and the interaction between nitric oxide (NO) and EETs…
- Trial name
- EETY (NCT01290198)
- Testing
- Microdialysis of fluconazole, vehicle and N(G)-nitro-L-arginine-methyl ester (L-NMMA)
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Hypertension,Essential
Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans
High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have…
- Trial name
- H2SPharm (NCT03179163)
- Testing
- Captopril Pill, Enalapril Pill, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Penn State University
Congenital Heart Disease
Microcirculation and Vascular Function After Fontan Surgery
Fontan Surgery is done for children with only one working lower chamber of the heart called the 'Single Ventricle'. This surgery involves making connections between the two big veins that drain oxygen deficient blood to the heart…
- Trial name
- MICROFON (NCT05683067)
- Testing
- Hand Held Capillary Microscopy, Mobile 'O' Graph, quality of life using questionnaires
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Diabetes Mellitus, Type 2
Influence of Acupuncture to Ocular Microcirculation in Patients With Diabetes Mellitus
The purpose of this study is to determine the influence of specific eye acupuncture to the ocular microcirculation in diabetic and healthy subjects.
- Trial name
- NCT01022177
- Testing
- acupuncture
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
HIV/AIDS
People Living With HIV/AIDS, Nitrate, Endotelial Function, Arterial Stiffness and Skeletal Muscle Oxygenation
Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality.
- Trial name
- NCT03485248
- Testing
- Beetroot Juice
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Infective Endocarditis
Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis
Infective endocarditis (IE) is a severe clinical condition with a high in-hospital and 5-year mortality. It has a growing incidence, both related to healthcare and possibly to changes in prophylaxis recommendations regarding oral…
- Trial name
- NCT02940340
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Metabolic Syndrome
NWT03 and Arterial Stiffness
Rationale: Subjects with the metabolic syndrome have an increased risk of developing cardiovascular disease and a twofold risk of developing hypertension.
- Trial name
- NCT02561663
- Testing
- NWT-03, an egg-white protein hydrolysate
- Where
- Netherlands
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Newtricious R&D BV
Microcirculatory Dysfunction, Tissue Hypoperfusion
Submental Tissue Oxygenation and Arterial Lactate in Major Surgery
During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects.
- Conditions
- Microcirculatory Dysfunction, Tissue Hypoperfusion, Microcirculatory Status, Microvascular Circulation
- Trial name
- NCT07399275
- Testing
- No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management.
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Chronic Renal Disease
Evaluation of Nail Fold Microcirculation in CKD
To evaluation of nailfold microcirculation in patients with chronic renal failure and its intervention therapy
- Trial name
- NCT03682952
- Testing
- Alprostadil Injection, Beraprost sodium tablets
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Omega-3 Polyunsaturated Fatty Acids
Omega-3 Fatty Acids Enriched Food and Microvascular Reactivity
Previous studies have shown that omega-3 fatty acid pills intake have beneficial effect on vascular health in overweight and/or hypertensive patients.
- Trial name
- NCT02720250
- Testing
- Omega-3 chicken eggs, Regular chicken eggs
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Hypertensive Heart Disease Without (Congestive) Heart Failure
The Influence of Beetroot Powder at a Dose of 20 g on Blood Pressure, Microcirculation, and Biochemical Markers in Men With Arterial Hypertension.SVEKLA2025.
Objective: to evaluate the effectiveness of using a food product, dry finely dispersed beetroot powder in a dose of 20 g, containing 800 mg of nitrate (NO3-), in relation to the regulation of blood pressure in men with…
- Trial name
- NCT07270718
- Testing
- Plus SVEKLA
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Biological Aging
Effects of Phytonutrients Upon Muscle Perfusion in Response to Feeding
This is a random order cross over design trial to evaluate the efficacy of select nutritional ingredients on enhancing muscle perfusion in response to an acute meal stimulus.
- Trial name
- NCT03213340
- Testing
- Catechin Cohort 1, Curcuminoid Cohort 2, Flavonoid Cohort 3
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Hyperbaric Oxygen Therapy
Effect of Hyperbaric Oxygen Therapy on Microcirculation
Previous studies shoes that hyperoxia alters microcirculation.The investigators hypothesize that hyperbaric may restore microcirculation integrity.
- Trial name
- MICROHB (NCT03980210)
- Testing
- Hyperbaric oxygen therapy
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Sublingual Microcirculation Pattern and Parameter Analysis
Machine Learning-assisted Analysis of Microcirculation Patterns and Parameters
Machine learning has been widely used in clinical medicine in recent years. It can be used for disease classification, disease severity grading, genetic testing, image analysis, adjuvant treatment recommendations, and predicting…
- Trial name
- NCT04957303
- Testing
- sublingual microcirculation video recording
- Where
- Taiwan
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Smoking Cessation, Cardiovascular Diseases
E-cigarettes and Cardiovascular Function
The large current uptake of e-cigarettes (2.8 million U.K. users in 2016; 26), the continuous involvement of e-cigarettes (which potentially affects their contents as well), the uncertainty about their medium- and longer-term…
- Conditions
- Smoking Cessation, Cardiovascular Diseases, Microcirculation, Macrocirculation
- Trial name
- ISME-NRT (NCT03061253)
- Testing
- Electronic Cigarette and behavioural change support., Nicotine-Free Electronic Cigarette and behavioural change support., Nicotine Replacement Therapy and behavioural change support.
- Where
- United Kingdom
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Critical Illness
Sublingual Microcirculation Monitoring in ICU
Prospective observational study designed to implement a daily monitoring of microcirculation and tissue oxygenation in all critically ill patients admitted to the ICU in the period of nine months, in order to assess the…
- Trial name
- MICRODAIMON (NCT02649088)
- Testing
- Microscan, NIRS from Hutchinson
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Università Politecnica delle Marche