Clinical trials: Microdialysis
Liver Transplant; Complications, Transplant; Failure, Liver
Liver Transplantation After ex Vivo Liver Perfusion
Today, it is difficult to predict liver function after transplantation and therefore livers where poor function is assumed (marginal livers) become discarded.
- Conditions
- Liver Transplant; Complications, Transplant; Failure, Liver, Transplant Dysfunction, Transplant; Complication, Rejection
- Trial name
- EVOLVE (NCT05951231)
- Testing
- Liver transplantation
- Volunteers
- 22 people
- Sponsor
- Oslo University Hospital
Osteoarthritis, Exercise
Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading
In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise.
- Trial name
- NCT01090375
- Testing
- Exercise, Non Exercise
- Sponsor
- Bispebjerg Hospital
Healthy
Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue
The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.
- Trial name
- NCT01595373
- Testing
- Acyl ghrelin
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Esben Thyssen Vestergaard
Coronary Artery Disease
Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake
The investigators are trying to determine if a single dose of Ticagrelor will increase delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with adenosine reuptake blockade.
- Trial name
- NCT01690884
- Testing
- Adenosine
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Shock
Continuous Central Venous Lactate Monitoring by Intravascular Microdialysis : a Comparison to Sequential Arterial Lactate Measurement During Shock.
During shock, arterial hypotension, inadequate cardiac output and microcirculatory alterations lead to tissue hypoxia, multiple organ failure and death. Arterial lactate is considered as the best marker of tissue hypoxia.
- Trial name
- NCT03464747
- Testing
- EIRUS system (Maquet Critical Care AB, 17154, Solna, Sweden)
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Glioblastoma
Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade
Background: Glioblastoma (GBM) brain tumors almost always return after treatment. When that happens the tumor can never completely be removed by surgery, so most people also receive drugs.
- Trial name
- NCT03493932
- Testing
- Nivolumab, BMS-986016
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Glioma, Glioblastoma
Feasibility of Intra- and Post-operative Microdialysis During Neurosurgery for Central Nervous System Lesions
This clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intra- and post-operative microdialysis during neurosurgery for central nervous system…
- Conditions
- Glioma, Glioblastoma, Metastatic Malignant Neoplasm in the Brain
- Trial name
- NCT04047264
- Testing
- Microdialysis, Magnetic Resonance Imaging, Computed Tomography
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Hypertension
Adiposity and Endothelin Receptor Function
Elevated levels of ET-1 have been implicated in cardiovascular disease and some forms of hypertension. Due to the strong, positive correlation between obesity and hypertension, the present study will explore the contribution of…
- Trial name
- END-RF (NCT03583866)
- Testing
- Candesartan
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Augusta University
Brain and Central Nervous System Tumors, Metastatic Cancer
A Feasibility, Dose-Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacodynamics of Temsirolimus in Patients With Primary or Metastatic Brain Tumors
RATIONALE: Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more…
- Trial name
- NCT00784914
- Testing
- temsirolimus, pharmacological study, cytokine levels
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- City of Hope Medical Center
Middle-aged Adults, Major Depressive Disorder
Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
The goal of this pilot clinical trial is to begin to understand how day-to-day stress affects cardiovascular health and brain function in middle-aged adults.
- Trial name
- NCT06466655
- Testing
- MitoTempol, Lactated Ringer's (control)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Traumatic Brain Injury
Excitatory Amino Acids and Activated Microglia After Traumatic Brain Injury: a (R)-[11C]PK11195 PET Study
Excitatory amino acids may be involved in secondary neuronal damage after traumatic brain injury. The amount of microglia activation is an indirect measure of neuronal damage.
- Trial name
- NCT00205582
- Testing
- Positron Emission Tomography
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Healthy, Dermal Pharmacokinetic Measurement
An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques
This will be a single center, open label, exploratory research study to assess the dermal and systemic PK of marketed products of lidocaine/prilocaine in 26 healthy participants using dermal open flow microperfusion (dOFM) and…
- Trial name
- NCT03813030
- Testing
- Intravenous infusion of lidocaine, Lidocaine 2.5% and Prilocaine 2.5% cream", USP (2.5% lidocaine, 2.5% prilocaine, Actavis Pharma incorporated, USA), Lidocorit 2%-Ampullen" (Gebro Pharma Gesellschaft mit beschränkter Haftung, Austria)
- Where
- Austria
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Joanneum Research Forschungsgesellschaft mbH
Liver Transplantation, Liver Graft Dysfunction
Tissue Microdialysis Monitoring of Liver Grafts
This study will investigate the dynamics of metabolic molecules sampled from human liver grafts during the early postoperative period using tissue microdialysis.
- Conditions
- Liver Transplantation, Liver Graft Dysfunction, Tissue Metabolism
- Trial name
- NCT06890234
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Acute Lung Injury
Human Bronchial Microdialysis in Open Aortic Aneurysm Repair
Elective open aortic aneurysm repair has an overall reported 30 day mortality of 2-6 percent, but in patients more than 65-70 years the mortality is reported to be more than 10 percent.
- Trial name
- NCT01322295
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- Norwegian University of Science and Technology
Obesity, Insulin Sensitivity
Effects of Regular Activity on Physiology Between Recreational Athletes of Different Body Fatness
The popularity of marathons and endurance events has increased over the last few decades and, interestingly, the demographics of participants have also changed.
- Trial name
- NCT05154422
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Florida State University
Skin Infections, Bacterial
Retapamulin Microdialysis Feasibility Study
This feasibility study will allow for the determination of the in vivo recovery and time of dialysis to optimize a future thorough microdialysis study.
- Trial name
- NCT01812382
- Testing
- Retapamulin Microdialysis
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Traumatic Brain INjury, Microdialysis
TBI Multimodal Monitoring Study
Head injury is a common and devastating condition that can affect people at any stage of their lives. The treatment of severe head injury takes place in intensive care where interventions are designed to protect the brain from…
- Trial name
- monTBI (NCT02993549)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Cambridge
Coronary Artery Stenosis
Comparing the Protective Effects of Two Cardioplegic Solutions, on Cardiac Metabolism, as Assessed Using Microdialysis
An estimated 8% to 15% of patients hospitalized for a coronary pathology undergo coronary revascularization surgery with extracorporeal circulation (ECC).
- Trial name
- Cardioplégie (NCT01401140)
- Testing
- St Thomas, Custodiol
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cancer
Peritoneal Microdialysis in Patients Undergoing Low Anterior Resection for Rectum Cancer
Anastomotic leakage is a serious complication after LAR with high morbidity and mortality rates. Early diagnosis and treatment is mandatory.
- Trial name
- NCT01062334
- Testing
- Peritoneal Microdialysis, CT-scan, leakage scoring
- Where
- 2 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Odense University Hospital
Brain and Central Nervous System Tumors, Metastatic Cancer
Temozolomide in Treating Patients With Primary Brain Tumors or Metastatic Brain Tumors
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00547131
- Testing
- temozolomide, laboratory biomarker analysis, liquid chromatography
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- City of Hope Medical Center