Clinical trials: Microdialysis
Traumatic Brain Injury
Copenhagen Head Injury Ciclosporin (CHIC) Study
This is an open label study on the pharmacokinetics and safety of ciclosporin in patients with severe traumatic brain injury, who require intensive care unit admission and monitoring of intracranial pressure via a ventricular…
- Trial name
- CHIC (NCT01825044)
- Testing
- NeuroSTAT 5 mg/kg/day, NeuroSTAT 10 mg/kg/day
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- NeuroVive Pharmaceutical AB
Coronary Artery Disease
Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake
The investigators are trying to determine if a single dose of Ticagrelor will increase delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with adenosine reuptake blockade.
- Trial name
- NCT01690884
- Testing
- Adenosine
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Microdialysis
Clinical Protocol of Sensitized Acupoint Changes in Knee Osteoarthritis Patients
Based on the research background and the preliminary research basis of the research group, in order to answer the material basis and micro-physical environment change characteristics of knee osteoarthritis sensitization acupoints…
- Trial name
- NCT03599180
- Testing
- microdialysis
- Where
- China
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Chinese Medical Association
Head Trauma
Ketamine and Glutamate After Brain Injury : a Microdialysis Study
The objective of the study is to compare the effects of 48 hours ketamine infusion versus sufentanil infusion on brain glutamate concentrations measured with microdialysis after traumatic brain injury.
- Trial name
- KETABRAIN (NCT02232347)
- Testing
- Ketamine, Sufentanil
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Pierre-Julien CUNGI
Ischemia
AMP as a Better Delivery System of Adenosine
Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks.
- Trial name
- NCT00179010
- Testing
- Adenosine, Adenosine Mono Phosphate (AMP)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Knee Injuries
Effects of Intraarticular IL1-Ra on Pain and Inflammatory Mediators After Knee Arhroscopy
This project investigates the relation between acute pain and local inflammation. Pain reported by the patients for knee arthroscopy are compared with local changes in inflammatory mediators by using microdialysis technique.
- Trial name
- NCT01997138
- Testing
- Anakinra 100 mg in 2 ml saline IA
- Where
- Norway
- Sponsor
- Oslo University Hospital
Kidney Diseases
Detecting Markers of Kidney Function With Intravenous Microdialysis
Patients will be invited to participate from an outpatient nephrology clinic at Hammersmith Hospital. They will have a microdialysis catheter inserted into a peripheral vein and connected to a sampling system.
- Trial name
- NCT03159806
- Testing
- Microdialysis sampling
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Accunea Ltd.
Knee Arthroscopy, Meniscus
Temperature Sensitive Release of PGE2 and Diminished Energy Requirements in Synovial Tissue With Postoperative Cryotherapy - A Prospective Randomised Study After Knee Arthroscopy
Abstract Background: Local external cooling of the postoperative field is a treatment paradigm aiming for enhanced recovery after joint surgery. It is supposed to reduce pain and improve mobilization, enabling same day surgery.
- Conditions
- Knee Arthroscopy, Meniscus, Inflammation, Hydrops
- Trial name
- NCT01247376
- Testing
- Cooling and compression
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Obesity
The Role of Atrial Natriuretic Peptide in the Lipolytic Process: Effect of Obesity and Exercise
In the developing countries, obesity prevalence is on a dramatic rise. Obesity is related to co-morbidities and as a result, obesity significantly shortens life expectancy and lowers quality of life.
- Trial name
- BALO (NCT02418728)
- Testing
- subcutaneous adipose tissue microdialysis under local beta/alpha blockade
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Postoperative; Dysfunction Following Cardiac Surgery
Cerebral Energy State in Cardiac Surgery
Impaired cerebral function remains an important complication of cardiopulmonary bypass (CPB) during cardiac surgery. The aim of the present study is to investigate whether the lactate to pyruvate (LP) ratio obtained by…
- Trial name
- NCT02846818
- Testing
- Microdialysis
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Cava-pulmonary Anastomosis
Surgical Site Infection Study
The purpose of this study is to investigate the pharmacokinetics of cefazolin using both plasma and microdialysate sampling methods in children with single ventricle physiology undergoing their second palliation procedure.
- Trial name
- SSI (NCT01449669)
- Volunteers
- 14 people
- Sponsor
- Children's Hospital of Philadelphia
Cancer of Rectum
Peritoneal Microdialysis in Patients Undergoing Low Anterior Resection (LAR) for Recto-sigmoid Cancer
Anastomotic leakage is a serious complication after LAR with high morbidity and mortality rates. Early diagnosis and treatment is mandatory.
- Trial name
- NCT00271986
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Nephrectomy, Kidney Cancer
Nephrotoxicity Associated to Parenchymal Clamping During Partial Nephrectomy Using a Microdialysis Technique
Surgery plays a central role in kidney cancer management being the only therapy that offers the possibility of healing the patients.
- Conditions
- Nephrectomy, Kidney Cancer, Microdialysis
- Trial name
- NECPAR (NCT02511275)
- Testing
- Renal microdialysis
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Surgical Wound Infection, Neck Infection
Antibiotic Tissue Penetration and Tissue Response in Head and Neck Infection and Reconstructive Surgery
The goal of this study is to measure how well commonly used antibiotics reach the tissue in the head and neck region in adults with a postoperative neck infection or undergoing reconstructive nasal surgery with an inferior…
- Conditions
- Surgical Wound Infection, Neck Infection, Nasal Reconstruction
- Trial name
- ANTIBIOTIKA (NCT07896239)
- Testing
- Cefuroxime, Dicloxacillin, Cloxacillin
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Tejs Ehlers Klug
Diabetes, Wound Infection
Omadacycline Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis
This study will determine the tissue penetration of the novel tetracycline antibiotic, omadacycline (Nuzyra, Paratek Pharmaceuticals, Inc.), into the extracellular, interstitial fluid of soft tissue in diabetic patients with…
- Conditions
- Diabetes, Wound Infection, Healthy Volunteers
- Trial name
- NCT04144374
- Testing
- Omadacycline, Microdialysis Catheter Insertion
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Microsurgery, Head and Neck Reconstructive Surgery
Monitoring of Bone Free Flaps With Microdialysis
Microdialysis is admitted to be reliable by numerous surgeons to monitor flaps. Nevertheless, a few authors reported follow up with microdialysis in bone flaps, and they all described the position of the catheter in the…
- Conditions
- Microsurgery, Head and Neck Reconstructive Surgery, Head and Neck Cancer, Head and/or Neck Shotgun Trauma
- Trial name
- MTM (NCT01879384)
- Testing
- CMA 70 catheter directly positioned in bone tissue
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Idiopathic Scoliosis
Skeletal Muscle and Adipose Tissue Study
The purpose of this research study is to compare the current standard of care for prophylactic Cefazolin administered every 3 hours intravenously with continuous infusion of Cefazolin during pediatric spinal surgery.
- Trial name
- NCT03190668
- Testing
- Bolus dose of Cefazolin, Continuous Cefazolin drip, Paraspinal muscle microdialysis catheters
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Postmenopause
Acute Metabolic Effects of Estradiol
Estradiol promotes and maintains the typical female phenotype characterized by subcutaneous fat accumulation. There is evidence to suggest that this effect relies on the ability of estradiol to increase the amount of…
- Trial name
- NCT00435175
- Testing
- estradiol
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy
Microdialysis and Pharmacokinetic Study of TR-701
The purpose of this study is to measure the penetration of TR-700 into subcutaneous adipose tissue and skeletal muscle after a single oral dose of 600 mg TR-701
- Trial name
- NCT00666601
- Testing
- TR-700 (active moiety), TR-701 (pro-drug)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Critical Illness Polyneuromyopathy (CIPNM), ICU Acquired Weakness (ICUAW)
Electrical Muscle Stimulation (EMS), a Preventive and Therapeutic Tool for Critical Illness Polyneuromyopathy (CIPNM)
The purpose of this study is to investigate the role of EMS as a preventive and therapeutic tool of CIPNM. The investigators hypothesized that EMS will prevent the development of CIPNM or have a beneficial role as a therapeutic…
- Trial name
- NCT00882830
- Testing
- EMS
- Where
- Greece
- Volunteers
- 52 people
- Sponsor
- University of Athens