Clinical trials: Microdialysis
Pancreatic Cancer, Pancreaticoduodenal; Fistula
Early Detection of Anastomotic Leakage by Microdialysis Catheters
Anastomotic leakage of the pancreatojejunostomy is often discovered with considerable delay, causing severe peritonitis, hemorrhage due to erosion of vessels, sepsis, and death.
- Conditions
- Pancreatic Cancer, Pancreaticoduodenal; Fistula, Pancreas; Fistula, Pancreatic Fistula
- Trial name
- NCT03627559
- Testing
- Pancreaticoduodenectomy microdialysis catheter analyses
- Volunteers
- 35 people
- Sponsor
- Oslo University Hospital
Type 1 Diabetes
Investigation of Correlation Between Concentrations of Glucose in Blood and Interstitial Fluid in Type 1 Diabetics
This is a mono-centre trial performed at the Center for Clinical Research at the Medical University Graz. There will be a screening information and a study visit.In the study visit arterialized venous blood glucose values will be…
- Trial name
- NCT00499954
- Testing
- Microdialysis, Guardian RT, Glucoday S
- Where
- Austria
- Volunteers
- 16 people
- Sponsor
- Medical University of Graz
Skin Infections, Bacterial
Retapamulin Microdialysis Feasibility Study
This feasibility study will allow for the determination of the in vivo recovery and time of dialysis to optimize a future thorough microdialysis study.
- Trial name
- NCT01812382
- Testing
- Retapamulin Microdialysis
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Volunteers
Thyroid and Fat Tissue Metabolism
This study will use a technique called microperfusion to examine how thyroid hormones are involved in fat metabolism. The thyroid gland produces two kinds of hormones: T3 and T4.
- Trial name
- NCT00312715
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Type 2 Diabetes
Adaptive Mechanisms In GRown up ObeSity Study (AMIGROS)
The investigator recently showed that the glycan-binding adipokine galectin-1 increased during overfeeding and that galectin-1 independently could predict type 2 diabetes.
- Trial name
- AMIGROS (NCT06065930)
- Testing
- Subcutaneous microdialysis
- Where
- Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Morbid Obesity
Cefazolin Subcutaneous Microdialysis in Morbidly Obese Patients
The investigators hypothesize that cefazolin perfusion to subcutaneous adipose tissue is reduced in morbidly obese patients. The primary objective of this exploratory pilot study is therefore to investigate target site…
- Trial name
- MICK (NCT01309152)
- Where
- 3 sites in Netherlands
- Volunteers
- 16 people
- Sponsor
- St. Antonius Hospital
Rupture, Venous Thromboembolism
Compression Treatment Effects on Complications and Healing of Achilles Tendon Rupture
This prospective randomized study aims to determine whether intermittent pneumatic compression (IPC), 75 patients, beneath functional bracing compared to treatment-as-usual in plaster cast, 75 patients, can reduce the Venous…
- Conditions
- Rupture, Venous Thromboembolism, Venous Thrombosis, Surgical Wound Infection
- Trial name
- NCT01317160
- Testing
- Intermittent pneumatic compression (IPC)
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska University Hospital
Other Functional Disturbances Following Cardiac Surgery
Continuous MONItoring of Blood LActate and Glucose Levels Using a New Central Veinous Microdialysis Catheter Device
Continuous lactate and glucose blood levels
- Trial name
- MONILAG (NCT02296593)
- Testing
- comparison of blood lactate and glucose levels
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Diabetes, Wound Infection
Tedizolid Tissue Penetration in Diabetic Patients With Wound Infections and Healthy Volunteers Via In Vivo Microdialysis
This study will determine the tissue penetration of tedizolid (Sivextro, Merck \& Co.), a novel oxazolidinone antibiotic, into the extracellular, interstitial fluid of soft tissue in diabetic patients with lower limb wound…
- Conditions
- Diabetes, Wound Infection, Healthy Volunteers
- Trial name
- NCT02620787
- Testing
- Tedizolid, Microdialysis Catheter Insertion
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Neck Pain
The Natural History of Upper Trapezius Myofascial Trigger Points: Comparison of Local and Remote Tissue Milieu in Normal Muscle, Latent and Active Myofascial Trigger Points Over Time
This study will use microdialysis to investigate myofascial pain. This pain is characterized by "trigger points" (exquisitely tender spots) in a group of tense muscle fibers that extend from the trigger point to the muscle…
- Trial name
- NCT00042276
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Bioequivalence
Clinical Study to Evaluate the Role of Microdialysis for the Comparison of Topical Products
The investigators hypothesize that a technique called microdialysis can be used to measure the amount of the drug diclofenac which penetrates (enters) the fatty tissue under the skin.
- Trial name
- NCT01592019
- Testing
- Reference, Patch location thigh, batch 1, Test, Patch location thigh, batch 2, Reference, Patch location abdomen, batch 1
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Florida
Endometriosis
Endometriosis and Microvascular Dysfunction: Role of Inflammation
The purpose of this study is to better understand the underlying mechanisms associated with elevated cardiovascular disease risk in women with endometriosis, and to measure the effectiveness of emerging endometriosis treatments…
- Trial name
- Endo3/SA2 (NCT05069740)
- Testing
- Salsalate Pill
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University
Brain Injuries, Traumatic
Proteomics of Severe Traumatic Brain Injury: A Feasibility Study
The purpose of this study is to: 1. Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury 2.
- Trial name
- NCT00522496
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Calgary
Liver Transplant; Complications, Transplant; Failure, Liver
Liver Transplantation After ex Vivo Liver Perfusion
Today, it is difficult to predict liver function after transplantation and therefore livers where poor function is assumed (marginal livers) become discarded.
- Conditions
- Liver Transplant; Complications, Transplant; Failure, Liver, Transplant Dysfunction, Transplant; Complication, Rejection
- Trial name
- EVOLVE (NCT05951231)
- Testing
- Liver transplantation
- Volunteers
- 22 people
- Sponsor
- Oslo University Hospital
Type 1 Diabetes
Performance Study to Test the GlucoMen®Day System Using Intravascular and Subcutaneous Microdialysis in Subjects With Type 1 Diabetes
Over the last years, a number of systems for continuous subcutaneous glucose monitoring have been marketed and are routinely used in patients with diabetes to obtain more detailed information about 24-hour glucose profiles.
- Trial name
- NCT01709851
- Testing
- Vascular microdialysis using the GMD-system, Vascular and subcutaneous microdialysis using the GMD-system
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Graz
Brain Injuries, Subarachnoid Hemorrhage
A Study Comparing Modified Lund Concept and Cerebral Perfusion Pressure-targeted Therapy in Secondary Brain Ischaemia.
Secondary brain ischaemia (SBI) usually develops after aneurysmal subarachnoid haemorrhage (SAH) and severe traumatic brain injury (TBI).
- Trial name
- NCT01206283
- Testing
- Modified Lund concept, Cerebral perfusion pressure-targeted therapy
- Where
- Bosnia and Herzegovina
- Volunteers
- 60 people
- Sponsor
- University of Sarajevo
Periprosthetic Knee Infection
Antibiotic Elution After Two-stage Knee Revision
The goal of this observational study is to monitor the eluted antibiotic concentrations of gentamicin and vancomycin by a static knee cement spacer in patients being treated for periprosthetic infections of the knee.
- Trial name
- NCT06944184
- Testing
- Intraarticular microdialysis
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bonn
Surgical Site Infection
Pharmacokinetic Study of Vancomycin, Clindamycin And/or Gentamicin Administration During Surgery Using a Microdialysis Procedure
The surgical site infection is one of the most important causes of postoperative morbidity. The appropriate antibiotic prophylaxis is one of the most effective way to prevent surgical site infections.
- Trial name
- NCT03845790
- Testing
- Blood and microdialysis samples
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Poitiers University Hospital
Diabetes
Real-time Continuous Glucose Monitoring in Diabetic Cardiothoracic Surgery Patients
An increased risk of adverse outcome is noted for diabetic patients admitted in surgery intensive care units (ICU). Tight glycemic control with intensive insulin therapy dramatically reduces in-hospital mortality and adverse…
- Trial name
- MARGE (NCT00878891)
- Testing
- Continuous glucose monitoring for immediate correction of abnormal glycemia
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Bordeaux
Transplant;Failure,Kidney
Real-time Monitoring of Kidney Grafts on Hypothermic Machine Perfusion
A significant number of deceased donor kidneys donated for transplantation are not used and are thrown away due to lack of ways of checking their condition and function before the operation.
- Trial name
- REMO-HYMAP (NCT04619732)
- Testing
- Monitoring biochemical concentrations during cold machine perfusion
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Accunea Ltd.