Clinical trials: Microfracture
Microfractures, Meniscus Tear
The Effectiveness of the Microfracture Technique in the Meniscal Healing
Meniscus injuries are a very common cause of knee pain. The meniscus is a semilunar fibrocartilage structure found on the medial and lateral sides of the knee.
- Trial name
- NCT05799196
- Testing
- Microfracture
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Hasanuddin University
Cartilage Defects of the Knee
Long-term Safety and Efficacy of CartiFill After Microfracture Surgery in Knee Cartilage Defects
The purpose of this clinical trial is to evaluate the safety and efficacy of CartiFill implanted at the site of knee joint cartilage defect in a 6-year, long-term, follow-up investigation.
- Trial name
- NCT07621172
- Testing
- CartiFill, Microfracture
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Cellontech Co., Ltd.
Hip Arthroscopy, Articular Cartilage Defect
AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
This is a pilot multi-centre RCT of 40 patients (ages 18-55 years, inclusive) undergoing primary hip arthroscopy with a focal articular cartilage defect of the acetabulum to compare the effect of using autologous matrix-induced…
- Conditions
- Hip Arthroscopy, Articular Cartilage Defect, Microfractures
- Trial name
- REPAIR (NCT05402072)
- Testing
- Autologous matrix-induced chondrogenesis (AMIC)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Tear; Knee, Cartilage, Articular
Arthroscopic Autologous Chondrocyte Implantation Versus Microfractures
This is a phase III, randomised controlled trial of matrix-encapsulated chondrocyte implantation procedure compared to the microfracture procedure in the repair of symptomatic cartilage lesions of the knee.
- Trial name
- NCT01947374
- Testing
- Matrix encapsulated chondrocyte implantation, Microfracture awl
- Where
- Mexico
- Volunteers
- 48 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Articular Cartilage Lesion of the Femoral Condyle
Efficacy and Safety Study of co.Don Chondrosphere to Treat Cartilage Defects
This is a prospective, phase III, multicenter, open label, randomised clinical trial of co.don chondrosphere®, a three-dimensional autologous chondrocyte transplantation product (ACT3D-CS)compared to the procedure of…
- Trial name
- NCT01222559
- Testing
- co.don chondrosphere®, Microfracture
- Where
- 12 sites in Germany, Poland
- Volunteers
- 102 people
- Sponsor
- co.don AG
Osteoarthritis, Knee
Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects
Subjects aged 50 to 65 years with knee cartilage defects will undergo microfracture treatment for cartilage regeneration and MegaCarti® will be applied.
- Trial name
- NCT06249828
- Testing
- MegaCarti®, Microfracture
- Where
- 7 sites in South Korea
- Volunteers
- 61 people
- Sponsor
- L&C Bio
Articular Cartilage Defects
Extension Study for Participants of MACI00206 Study of MACI® for the Treatment of Symptomatic Articular Cartilage Defects of the Knee
To examine the 5-year efficacy and safety of MACI implant, compared with arthroscopic microfracture, in participants who received study treatment in the SUMMIT study for treatment of symptomatic articular cartilage defects of the…
- Trial name
- Extension (NCT01251588)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Microfracture
- Where
- 14 sites in Czechia, France and 5 more
- Volunteers
- 128 people
- Sponsor
- Vericel Corporation
Articular Cartilage Defect
Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
The objective of this trial is to demonstrate superior efficacy and safety of MACI compared with arthroscopic microfracture in the treatment of patients (aged 18 to 55 years) with symptomatic articular cartilage defects of the…
- Trial name
- SUMMIT (NCT00719576)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Microfracture
- Where
- 20 sites in Czechia, France and 5 more
- Volunteers
- 144 people
- Sponsor
- Vericel Corporation
Femoroacetabular Impingement, Chondral Lesions
Efficacy of PRP (Platelet Rich Plasma) Following Arthroscopic Microfracture of Chondral Lesions of the Hip
The purpose of this research project is to assess the effectiveness of intra-articular injections of autologous platelet-rich plasma (PRP) after arthroscopic microfracture.
- Trial name
- NCT02183896
- Testing
- Platelet-rich plasma (PRP), Saline
- Where
- United States
- Sponsor
- University of Colorado, Denver
Defect of Articular Cartilage, Cartilage Injury
Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair
This is a proof-of-concept study to determine the safety and efficacy of a novel device to increase the reparative capacity of the knee.
- Conditions
- Defect of Articular Cartilage, Cartilage Injury, Osteoarthritis, Knee
- Trial name
- AURA (NCT02696876)
- Testing
- Arthroscopic synovial brushing, Microfracture
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University of Leeds
Femoro-acetabular Impingement (FAI)
Comparison of Minced Cartilage Implantation Versus Microfracture for Acetabular Chondral Lesions Due to FAI (Femoro-acetabular Impingement)
A femoroacetabular impingement (FAI) is an abnormal contact between pelvis and the neck of femur. It occurs particularly when patient bends his hip and causes damage to the cartilage.
- Trial name
- CARTIFRAC (NCT07657871)
- Testing
- Minced cartilage implantation - MCI, Microfracture
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Knee Osteoarthritis (Knee OA)
Comparison of SVF Injection With and Without Microfracture in Moderate Knee Osteoarthritis
This prospective, randomized controlled clinical trial aims to evaluate the clinical and radiological effects of combining stromal vascular fraction (SVF) therapy with arthroscopic microfracture in patients with knee…
- Trial name
- NCT07112885
- Testing
- Arthroscopic Microfracture Combined with Autologous SVF Injection, Arthroscopic Debridement Followed by Autologous SVF Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Osteoarthritis, Knee
Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects
The MegaCarti® is the decellularized allogeneic cartilage and acts as a cover after bone marrow stimulation to prevent the loss of blood clots and induces cartilage regeneration by assisting in the location of stem cells derived…
- Trial name
- NCT05440370
- Testing
- MegaCarti®, Microfracture
- Where
- 4 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- L&C Bio
Lateral Ligament Repair, Talar Cartilage Lesion
Microfracture Technique for Talar Articular Cartilage Lesions With or Without Lateral Ligament Repairment
To study the clinical efficacy of microfracture combined with lateral ligament repairment for cartilage lesions of talus through the comparison between microfracture with and without lateral ligament repairment.
- Conditions
- Lateral Ligament Repair, Talar Cartilage Lesion, Microfracture
- Trial name
- NCT03064399
- Testing
- without lateral ligament repairment, lateral ligament repairment
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Defect of Articular Cartilage
the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Ankle
This study was designed to evaluate the efficacy and safety of a modified microfracture using collagen, and to compare them with those of a simple microfracture in patients with cartilage defects in their ankles.
- Trial name
- NCT02519881
- Testing
- Microfracture, CartiFill
- Where
- 3 sites in South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Defect of Articular Cartilage, Osteoarthritis
Comparison of Efficacy and Safety of Microfracture and Modified Microfracture
This study was designed to evaluate the efficacy and safety of a modified microfracture using collagen, and to compare them with those of a simple microfracture to prove the non-inferiority of the modified microfracture using…
- Conditions
- Defect of Articular Cartilage, Osteoarthritis, Traumatic Arthritis
- Trial name
- NCT02539030
- Testing
- Microfracture, CartiFill
- Where
- 12 sites in South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Anterior Cruciate Ligament Reconstruction, Subchondral Microfractures of Tibia
Subchondral Microfracture of Tibia After Arthroscopic Anterior Cruciate Ligament Surgery Reconstruction
The arthroscopic anterior cruciate (ACL) ligament reconstruction surgery is widespread. The creation of the tibial tunnel, retrograde or antegrade, is not consensual.
- Trial name
- NCT01588977
- Where
- 3 sites in France
- Volunteers
- 43 people
- Sponsor
- Hospital Ambroise Paré Paris
Degenerative Lesion of Articular Cartilage of Knee
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the…
- Trial name
- NCT02090140
- Testing
- ADSC Application, Microfracture
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Osteochondral Fracture of Talus
The Effectiveness of Adding Allogenic Stem Cells After Traditional Treatment of Osteochondral Lesions of the Talus
Randomized, multicentric, prospective, double-blind study: effectiveness of adding allogenic stem cells to a platelet-poor plasma scaffold after arthroscopic debridement and microfractures in patients with osteochondral lesions…
- Trial name
- OLT (NCT03905824)
- Testing
- Allogenic stromal mesenchymal cells derived from the umbilical cord, Debridement and microfracture
- Where
- Chile
- Volunteers
- 70 people
- Sponsor
- University of Chile