Clinical trials: Microgravity
Maximum Voluntary Contraction
Muscular Force Generation in Microgravity
The aim of this study is to evaluate the applicability of high-load resistance training as a countermeasure for long term space flights, the current project has two scientific goals.
- Trial name
- ForceGeneratio (NCT02850328)
- Testing
- examination of muscle function and MVC in weightlessness
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Simulated Microgravity by Head Down Tilt Bedrest, Weightlessness
A 60 Days Head Down Tilt Bedrest With Artificial Gravity and Cycling Exercise on 24 Healthy Male (BRACE)
The objective of this study is to investigate whether a cycling exercise coupled with artificial gravity via a short-arm human centrifuge helps to prevent and / or reduce the deleterious effects induced by 60 days of…
- Trial name
- BRACE (NCT06544213)
- Testing
- Control Group, Countermeasure Supine Bike, Countermeasure AG-Bike
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Unilateral Lower Limb Suspension (Simulated Microgravity)
Unloaded Minds - How Prolonged Unloading Shapes Human Performance in Lunar Gravity
During spaceflight and lunar missions, reduced gravitational loading causes the muscles and nervous system to decondition rapidly.
- Trial name
- UnloadedMinds (NCT07607340)
- Testing
- Unilateral lower limb suspension
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Weightlessness
Space Flight Simulation to Study Effects of Micro-gravity Through Bed Rest
Space flight simulation study to study effects of microgravity through bedrest coupled with flight exercise counter-measures.
- Trial name
- FAP (NCT00891449)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Healthy Volunteers
Effects of Microgravity on Central Aortic Pressure During Parabolic Flights
Cardiovascular events remain the main cause of death of the industrialized world (Global status report on noncommunicable diseases 2010. Geneva, World Health Organization, 2011).
- Trial name
- CapFlight (NCT02789072)
- Testing
- central aortic pressure (measured in mmHg).
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Weightlessness
A 5-day Dry Immersion Study on 20 Healthy Male Volunteers
Dry immersion (DI) is a ground-based model of prolonged conditions of simulated microgravity. Dry immersion involves immersing the subject in water covered with an elastic waterproof fabric.
- Trial name
- VIVALDI2 (NCT05493176)
- Testing
- Dry immersion
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Cardiovascular Diseases
A 3D Hydrogel Model to Assess Endothelial Cell-macrophage Interactions in Simulated Microgravity (OR-DRPD-SRI2019)
The proposal contained herein seeks to examine the effect of simulated microgravity on important cell-cell interactions that govern vascular health. The interest lies in endothelial cell (EC) and macrophage cell interactions.
- Trial name
- NCT04028752
- Testing
- Blood collected specifically for this study
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Weightlessness, Weightlessness; Adverse Effect
A New Nutritional Countermeasure to Prevent the Deconditioning Induced by 60 Days of Antiorthostatic Bed Rest
The objective of this study is to investigate whether the cocktail of natural antioxidants XXS-2A-BR2 comprising vitamin E and coupled with omega-3 helps to prevent and / or reduce the deleterious effects induced by long term…
- Trial name
- LTBRCocktail (NCT03594799)
- Testing
- Bed Rest Control Group, Cocktail intervention
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Immune Function and Intestinal Microbiota
Probiotics on Immune Function and Intestinal Microbiota in Astronauts Under Closed Microgravity Environment
Human immune function and intestinal microbiota are suggested to be altered within long-duration stay in space. Accumulated evidences on earth support that Lacticaseibacillus paracasei strain Shirota (LcS) is a promising…
- Trial name
- NCT02618005
- Testing
- Probiotic capsule
- Where
- Japan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yakult Honsha Co., LTD
Microgravity, Neuroplasticity
Neuroimage Genome Study of Neuroplasticity Associated With Microgravity
This clinical trial investigates the neuroplasticity and cognitive status changes of the human brain in microgravity. To explore the relationship between cognitive status changes and brain functional activities, gray matter and…
- Conditions
- Microgravity, Neuroplasticity, MRI, Repeatable Battery for the Assessment of Neuropsychological Status
- Trial name
- NCT06350422
- Testing
- Head-Down tilt Bed Rest test
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Uterine, Ovary
Female Pelvic Blood Flow Under Simulated Microgravity
Spaceflight is characterized by unique physiological adaptations. Cardiovascular system response to the microgravity includes major changes.
- Conditions
- Uterine, Ovary, Microgravity, Blood Flow
- Trial name
- NCT06633692
- Testing
- Head down tilt (HDT)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ceren UNAL
Cardiovascular Diseases
The Role of the Space Environment on Vascular Endothelial and Smooth Muscle Cell Processes
By studying the affect of the space environment on vascular cell types, our goal is to elucidate the mechanism of vascular cell damage in the space environment by exposing vascular cells to space flight.
- Trial name
- OR-DRPD-SRI (NCT03156257)
- Testing
- Blood volume collected specifically for this study
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Florida
Physiological Stress
Operational Performance Effects and Neurophysiology in Partial Gravity
Aim 1: Characterize and quantify changes in operationally-relevant sensorimotor and vestibular performance as a function of gravitational load.
- Trial name
- OPEN-PG (NCT06736652)
- Testing
- Parabolic flight
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Weightlessness, Weightlessness; Adverse Effect
Thigh Cuffs to Prevent the Deconditioning Induced by 5 Days of Dry Immersion
The objective of the study is to investigate whether thigh cuffs help to prevent and/or reduce the deconditioning induced by 5 days of dry immersion and in particular the fluid shift and its related ophthalmological disorders.
- Trial name
- DI-Cuff (NCT03915457)
- Testing
- Dry immersion Control Group, Thigh cuffs intervention
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Healthy Volunteers
E-NOSE for Breath Gas Analysis Under Microgravity Conditions
The main goal of the study is demonstrate that e-Nose system function is not altered in weightlessness and more specifically that gas concentration measurements are the same in weightlessness and normal gravity.
- Trial name
- E-NOSE (NCT02507622)
- Testing
- measurement of the concentration of C02, CO and NH4, 3 exhaled gas with E-Nose system, Parabolic flight
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Weightlessness, Cerebral Blood Flow
Cerebral Blood Flow Distribution During Parabolic Flight-induced Microgravity
When astronauts return from space flight, they manifest a set of symptoms, the most striking of which is orthostatic intolerance, that is, the inability to stay upright.
- Trial name
- GraCer (NCT03986788)
- Testing
- Weightlessness
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Airway Management, Emergency Medicine
Airway Management With Simulated Microgravity Using a Submerged Model
Trained anesthesiologist- or emergency physician-divers will perform an airway management in simulated microgravity on a submerged model.
- Trial name
- AirMicroMod (NCT03848559)
- Testing
- Airway management with a submerged model
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Universitätsklinikum Köln
Cardiovascular Deconditioning
Responses of the Cardiovascular Systems to Leg Exercises in Microgravity-like Conditions
One of the major issues in space explorations is the negative effect of prolonged exposure to very low gravity (i.e. a condition often referred to as microgravity or weightlessness) on astronauts' health.
- Trial name
- STAMAS (NCT02313142)
- Testing
- Leg exercises
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Sarcopenia
Electrical Stimulation of Human Myocytes in Microgravity
The purpose of this study is to evaluate the changes of muscle, in microgravity. Which will help explain the health benefits of exercise.
- Trial name
- microG (NCT03665051)
- Testing
- Muscle Tissue Biopsy, Maximal Oxygen Consumption (V02max)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Healthy
Effects of Repeated Short-term Microgravity During Parabolic Flight Conditions on Neuro-endocrine, Immune and Metabolic Changes
From previous parabolic flight campaigns completed by our research group investigators gathered data showing important changes in neuro-endocrine and also immunological changes.
- Trial name
- COSI@PFC (NCT02517190)
- Testing
- Parabolic flight, neuro-endocrine measurements, immunological measurements
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen