Clinical trials: Microparticles
Acne Vulgaris
Sebacia Postmarket Study of Real-World Use
Postmarket study of Sebacia Microparticles treatment during adoption into clinical use for patients with mild to moderate inflammatory acne vulgaris.
- Trial name
- NCT03818555
- Testing
- Sebacia Microparticles Treatment
- Where
- 6 sites in United States
- Volunteers
- 125 people
- Sponsor
- Sebacia, Inc.
Acute Promyelocytic Leukemia
Role of Microparticles in the Coagulopathy of Acute Promyelocytic Leukemia
Although the clinical application of differentiation therapy has made great success in the treatment of acute promyelocytic leukemia (APL), early fatal bleeding remains an unsolved problem which accounts for the main reason of…
- Trial name
- NCT02991066
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Systemic Inflammation
Influence of In-line Microfilters on Systemic Inflammation in Adult Critically Ill Patients
Studies showed that infusion or injection of drugs and fluids results in introduction of microparticles into the bloodstream. These microparticles may cause organ damage and stimulate the immune system thus aggravating the…
- Trial name
- NCT01534390
- Testing
- In-line microfilter (Supor IV Filter; Pall Corporation, Port Washington, New York)
- Where
- Austria
- Volunteers
- 504 people
- Sponsor
- University of Salzburg
Hereditary Spherocytosis
Hereditary Spherocytosis and Vascular Function
Background : Patients with hereditary spherocytosis (HS) are characterized by increased red blood cell (RBC) fragility and a loss of RBC deformability.
- Trial name
- VASCUSPHERO (NCT04451785)
- Testing
- blood sample, Pulse wave velocity
- Where
- 2 sites in France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Malignant Pleural Effusion
Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion
The study is to investigate the anticancer effect and the related immunological mechanism of MTX-ATMPs in the treatment of malignant pleural effusion.
- Trial name
- NCT02657460
- Testing
- tumor derived microparticles, cisplatin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Healthy
Effects of E-smoke on Levels of Endothelial Progenitor Cells and Microparticles in Healthy Volunteers
We plan to investigate the acute effects of inhaling e-cigarette vapor on cell function measured by microvesicles and endothelial progenitor cells.
- Trial name
- ESMOKE (NCT02532894)
- Testing
- Electronic cigarette
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Lung Cancer, Breast Cancer
Safety and Effectiveness of MPCD Therapy on the Treatment of Malignant Pleural Effusion
This is a prospective, open-label , multicenter randomized controlled trial, with 248 cases in 50 centers planned for a period of 2 years.
- Conditions
- Lung Cancer, Breast Cancer, Malignant Pleural Effusion
- Trial name
- NCT04131231
- Testing
- microparticles packaging methotrexate (MPs-MTX), recombinant human interleukin-2(rhIL-2)
- Volunteers
- 248 people
- Sponsor
- Peking Union Medical College
Coronary Artery Bypass
Microparticles in Stored RBC as Potential Mediators of Transfusion Complications
INTRODUCTION. Cell-derived microparticles (MP) are released in cell activation, apoptosis and other processes. MP derived from red cells (RMP) are known to be released from stored packed red blood cells (PRBC), and their number…
- Trial name
- NCT01185600
- Testing
- Washed RBC, Unwashed RBC
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Miami
the Coagulolytic Balance, the Mortality Rate
Interest of the Balance of Pro-coagulating and Profibrinolytis Activities of the Microparticles (MP) in the Prognosis of Septic Shock
Septic shock is a clinical syndrome occurring in 10 to 20% of patients admitted in ICV. Mortality associated to septic shock varies from 30 to 50%.
- Conditions
- the Coagulolytic Balance, the Mortality Rate, the Performance Used to Evaluate the Principal Objective Are Technical Performances, Sensibility and Specificity of the Tests
- Trial name
- NCT02062970
- Testing
- blood draw
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Oxidative Stress, Cell-derived Microparticles
Pik Lenin High Altitude Research Expedition 2009
Exposure to hypobaric hypoxia demands maximum effort of the body and can lead to high altitude illnesses. Recently, there is rising interest on coagulation activation during trekking and mountaineering in higher regions and on…
- Trial name
- PLHARE (NCT01571687)
- Testing
- antioxidant supplements
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Systemic Sclerosis, Pulmonary Hypertension
Endothelial Microparticles in Systemic Sclerosis Pulmonary Hypertension
Systemic sclerosis (SSc, also known as scleroderma) is a disease characterized by fibrosis of the skin and organs, inflammation, and an abnormal endothelial cell lining inside of vessels.
- Conditions
- Systemic Sclerosis, Pulmonary Hypertension, Scleroderma
- Trial name
- NCT02331225
- Testing
- No intervention given
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Ruptured Cerebral Aneurysm, Ruptured Berry Aneurysm
Safety and Tolerability Study of EG-1962 in Aneurysmal Subarachnoid Hemorrhage
Phase 1/2a Multicenter, Controlled, Randomized, Open Label, Dose Escalation, Safety, Tolerability, and Pharmacokinetic Study Comparing EG-1962 and Nimodipine in Patients with Aneurysmal Subarachnoid Hemorrhage
- Trial name
- NEWTON (NCT01893190)
- Testing
- Nimodipine, Nimodipine Microparticles
- Where
- 23 sites in United States, Canada and 2 more
- Volunteers
- 73 people
- Sponsor
- Edge Therapeutics Inc
Healthy Donor
Lipid Characterisation of Plasma Microparticles in a Large Population of Healthy Donors
Extracellular vesicles (EVs) are membrane structures containing numerous mediators categorised according to their size and mode of production.
- Trial name
- MicroLipids (NCT06183632)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Obesity
TIFACT Study - Tissue Factor Expression by Adipose Tissue in Extremely Obese Subjects.
Tissue factor is the main activator of coagulation cascades. Excessive tissue factor expression is made responsible of thrombosis in a number of clinical situations including thrombosis in contact with atherosclerotic plaques.
- Trial name
- NCT00379704
- Where
- France
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acne Vulgaris, Microparticles
Multimodal Optical Imaging for Pretreatment Evaluation for Cutaneous Microparticle Delivery
The purpose of this study is to investigate how pretreatment with a topical medication for acne affects application and delivery of gold microparticles to the skin in acne patients.
- Trial name
- NCT03573115
- Testing
- Adapalene-Benzoyl Peroxide Gel 0.1-2.5%
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Merete Haedersdal
Seasonal Allergic Rhinitis
Phase I/IIa Study on Chitin Microparticles in Subjects Suffering From Allergic Rhinitis
Chitin microparticles (CMP) has been demonstrated in animal studies that have modelled allergic rhinitis to be effective against a wide range of common respiratory allergens. It is an immuneenhancer.
- Trial name
- NCT00443495
- Testing
- Chitin microparticles by nasal route
- Volunteers
- 24 people
- Sponsor
- CMP Therapeutics Ltd
Malignant Ascites
Clinical Study of Autologous Erythrocytes Derived MPs Packaging MTX Peritoneal Perfusion to Treat Malignant Ascites
This study makes an observation over the objective response rate of autologous erythrocytes derived microparticles packaging methotrexate peritoneal perfusion and systemic therapy combination in the treatment of malignant…
- Trial name
- NCT03230708
- Testing
- Erythrocytes derived MPs containing MTX, convention drugs
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Hui ting Xu，MD
Musculoskeletal Pain, Osteoarthritis
Testing the Characteristics of Platelet Rich Plasma in Sports Medicine
This is an observational study that evaluates the characteristics of Platelet Rich Plasma used in the therapy and treatment of musculoskeletal injuries and degenerative joint diseases.
- Trial name
- PRiSM (NCT02726464)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Thalassemia Major (TM), Thalassemia Intermedia (TI)
Beta-thalassemia and Microparticles
The results will allow us to evaluate the role of MP in the thrombo-embolic risk observed in thalassemic patients and to underline a possible difference between TM and TI.
- Conditions
- Thalassemia Major (TM), Thalassemia Intermedia (TI), Microparticles (MP)Originating From Platelets, Endothelial Cells and Monocytes
- Trial name
- NCT01284738
- Testing
- Physiopathology
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Advanced Pancreatic, Colon, Lung, Gastric and Ovarian Cancer
Enoxaparin Thromboprophylaxis in Cancer Patients With Elevated Tissue Factor Bearing Microparticles
Research studies have shown a strong association between cancer and blood clots in the veins (also known as deep vein thrombosis).
- Trial name
- MicroTEC (NCT00908960)
- Testing
- Enoxaparin
- Where
- 5 sites in United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center